KEGG   PATHWAY: hsx00260
Entry
hsx00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Billgrantia sulfidoxydans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
hsx00260  Glycine, serine and threonine metabolism
hsx00260

Module
hsx_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:hsx00260]
hsx_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:hsx00260]
hsx_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:hsx00260]
hsx_M00555  Betaine biosynthesis, choline => betaine [PATH:hsx00260]
hsx_M00621  Glycine cleavage system [PATH:hsx00260]
hsx_M00919  Ectoine degradation, ectoine => aspartate [PATH:hsx00260]
hsx_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:hsx00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Billgrantia sulfidoxydans [GN:hsx]
Gene
HNO51_02825  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HNO51_19860  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HNO51_12655  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HNO51_02245  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HNO51_19390  homoserine kinase [KO:K02204] [EC:2.7.1.39]
HNO51_02250  threonine synthase [KO:K01733] [EC:4.2.3.1]
HNO51_01300  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HNO51_15365  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HNO51_16330  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HNO51_10805  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
HNO51_15795  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
HNO51_16155  glycerate kinase [KO:K11529] [EC:2.7.1.165]
HNO51_20195  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
HNO51_00145  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HNO51_00435  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HNO51_16885  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HNO51_11670  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HNO51_15980  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HNO51_14675  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HNO51_17330  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
HNO51_17325  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
HNO51_11100  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HNO51_11085  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HNO51_03375  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HNO51_06530  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HNO51_11095  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HNO51_01270  M24 family metallopeptidase [KO:K08688] [EC:3.5.3.3]
HNO51_18455  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HNO51_13605  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
HNO51_10000  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
HNO51_13600  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HNO51_20335  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
HNO51_20330  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
HNO51_20370  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
HNO51_20365  (Fe-S)-binding protein [KO:K21834]
HNO51_20360  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
HNO51_20355  electron transfer flavoprotein subunit beta [KO:K25961]
HNO51_01315  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
HNO51_01305  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
HNO51_01320  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
HNO51_01310  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
HNO51_04915  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HNO51_00095  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HNO51_08560  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
HNO51_15740  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
HNO51_00415  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
HNO51_03570  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
HNO51_03835  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HNO51_12630  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HNO51_03840  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HNO51_12635  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HNO51_10670  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
HNO51_10675  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
HNO51_10665  ectoine synthase [KO:K06720] [EC:4.2.1.108]
HNO51_14005  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
HNO51_19405  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
HNO51_15785  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
HNO51_15780  doeB; N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
HNO51_15745  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K15785] [EC:2.6.1.76]
HNO51_15750  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
hsx00010  Glycolysis / Gluconeogenesis
hsx00020  Citrate cycle (TCA cycle)
hsx00230  Purine metabolism
hsx00250  Alanine, aspartate and glutamate metabolism
hsx00270  Cysteine and methionine metabolism
hsx00290  Valine, leucine and isoleucine biosynthesis
hsx00300  Lysine biosynthesis
hsx00330  Arginine and proline metabolism
hsx00460  Cyanoamino acid metabolism
hsx00470  D-Amino acid metabolism
hsx00564  Glycerophospholipid metabolism
hsx00620  Pyruvate metabolism
hsx00630  Glyoxylate and dicarboxylate metabolism
hsx00640  Propanoate metabolism
hsx00680  Methane metabolism
hsx00860  Porphyrin metabolism
hsx00920  Sulfur metabolism
KO pathway
ko00260   
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