KEGG   PATHWAY: kva02020
Entry
kva02020                    Pathway                                
Name
Two-component system - Klebsiella variicola At-22
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
kva02020  Two-component system
kva02020

Other DBs
GO: 0000160
Organism
Klebsiella variicola At-22 [GN:kva]
Gene
Kvar_4040  PAS/PAC sensor signal transduction histidine kinase [KO:K07636] [EC:2.7.13.3]
Kvar_4041  two component transcriptional regulator, winged helix family [KO:K07657]
Kvar_4054  Alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
Kvar_5086  phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
Kvar_3244  integral membrane sensor signal transduction histidine kinase [KO:K07637] [EC:2.7.13.3]
Kvar_3243  two component transcriptional regulator, winged helix family [KO:K07660]
Kvar_1540  two component transcriptional regulator, winged helix family [KO:K07660]
Kvar_3108  Acid phosphatase [KO:K09474] [EC:3.1.3.2]
Kvar_0327  integral membrane sensor signal transduction histidine kinase [KO:K07638] [EC:2.7.13.3]
Kvar_0326  two component transcriptional regulator, winged helix family [KO:K07659]
Kvar_1417  porin Gram-negative type [KO:K09475]
Kvar_3420  porin Gram-negative type [KO:K09476]
Kvar_4999  integral membrane sensor signal transduction histidine kinase [KO:K07640] [EC:2.7.13.3]
Kvar_4998  two component transcriptional regulator, winged helix family [KO:K07662]
Kvar_0574  conserved hypothetical protein [KO:K25864]
Kvar_2840  integral membrane sensor signal transduction histidine kinase [KO:K07639] [EC:2.7.13.3]
Kvar_2837  two component transcriptional regulator, winged helix family [KO:K07661]
Kvar_4205  protease Do [KO:K04771] [EC:3.4.21.107]
Kvar_4397  integral membrane sensor signal transduction histidine kinase [KO:K07641] [EC:2.7.13.3]
Kvar_4398  two component transcriptional regulator, winged helix family [KO:K07663]
Kvar_1533  integral membrane sensor signal transduction histidine kinase [KO:K07642] [EC:2.7.13.3]
Kvar_1532  two component transcriptional regulator, winged helix family [KO:K07664]
Kvar_1537  efflux transporter, RND family, MFP subunit [KO:K07799]
Kvar_1536  acriflavin resistance protein [KO:K07788]
Kvar_1535  acriflavin resistance protein [KO:K07789]
Kvar_1534  major facilitator superfamily MFS_1 [KO:K18326]
Kvar_1252  transporter, hydrophobe/amphiphile efflux-1 (HAE1) family [KO:K18324]
Kvar_3575  integral membrane sensor signal transduction histidine kinase [KO:K07643] [EC:2.7.13.3]
Kvar_3574  two component transcriptional regulator, winged helix family [KO:K07771]
Kvar_0254  DegT/DnrJ/EryC1/StrS aminotransferase [KO:K07806] [EC:2.6.1.87]
Kvar_4535  multi-sensor signal transduction histidine kinase [KO:K07644] [EC:2.7.13.3]
Kvar_4536  two component transcriptional regulator, winged helix family [KO:K07665]
Kvar_4537  RND efflux system, outer membrane lipoprotein, NodT family [KO:K07796]
Kvar_4538  periplasmic copper-binding protein [KO:K07810]
Kvar_4539  efflux transporter, RND family, MFP subunit [KO:K07798]
Kvar_4540  heavy metal efflux pump, CzcA family [KO:K07787]
Kvar_0655  integral membrane sensor signal transduction histidine kinase [KO:K07645] [EC:2.7.13.3]
Kvar_0656  two component transcriptional regulator, winged helix family [KO:K07666]
Kvar_3657  Osmosensitive K channel His kinase sensor [KO:K07646] [EC:2.7.13.3]
Kvar_3658  two component transcriptional regulator, winged helix family [KO:K07667]
Kvar_3654  potassium-transporting ATPase, A subunit [KO:K01546]
Kvar_3655  K+-transporting ATPase, B subunit [KO:K01547] [EC:7.2.2.6]
Kvar_3656  potassium-transporting ATPase, C subunit [KO:K01548]
Kvar_0480  multi-sensor hybrid histidine kinase [KO:K07648] [EC:2.7.13.3]
Kvar_4395  two component transcriptional regulator, winged helix family [KO:K07773]
Kvar_0005  chromosomal replication initiator protein DnaA [KO:K02313]
Kvar_4800  TonB-dependent siderophore receptor [KO:K19611]
Kvar_3766  TonB-dependent siderophore receptor [KO:K19611]
Kvar_4329  signal transduction histidine kinase regulating citrate/malate metabolism [KO:K07700] [EC:2.7.13.3]
Kvar_4360  signal transduction histidine kinase regulating citrate/malate metabolism [KO:K07700] [EC:2.7.13.3]
Kvar_4330  response regulator receiver and unknown domain protein [KO:K07702]
Kvar_4361  response regulator receiver and unknown domain protein [KO:K07702]
Kvar_4355  citrate lyase ligase [KO:K01910] [EC:6.2.1.22]
Kvar_4354  citrate lyase acyl carrier protein [KO:K01646]
Kvar_4353  citrate lyase, beta subunit [KO:K01644] [EC:4.1.3.34]
Kvar_4352  citrate lyase, alpha subunit [KO:K01643] [EC:2.8.3.10]
Kvar_4327  holo-ACP synthase CitX [KO:K05964] [EC:2.7.7.61]
Kvar_4351  triphosphoribosyl-dephospho-CoA synthase CitG [KO:K05966] [EC:2.4.2.52]
Kvar_2807  signal transduction histidine kinase regulating citrate/malate metabolism [KO:K07701] [EC:2.7.13.3]
Kvar_1736  response regulator receiver and unknown domain protein [KO:K07703]
Kvar_2808  response regulator receiver and unknown domain protein [KO:K07703]
Kvar_4875  anaerobic c4-dicarboxylate antiporter, Dcu family [KO:K07792]
Kvar_1737  Malate dehydrogenase (oxaloacetate-decarboxylating) [KO:K00027] [EC:1.1.1.38]
Kvar_2456  Malate dehydrogenase (oxaloacetate-decarboxylating) [KO:K00027] [EC:1.1.1.38]
Kvar_1739  Citrate carrier protein [KO:K11616]
Kvar_1966  integral membrane sensor signal transduction histidine kinase [KO:K07673] [EC:2.7.13.3]
Kvar_1965  two component transcriptional regulator, LuxR family [KO:K07684]
Kvar_1969  nitrate reductase, alpha subunit [KO:K00370] [EC:1.7.5.1 1.7.99.-]
Kvar_1970  nitrate reductase, beta subunit [KO:K00371] [EC:1.7.5.1 1.7.99.-]
Kvar_1972  respiratory nitrate reductase, gamma subunit [KO:K00374] [EC:1.7.5.1 1.7.99.-]
Kvar_1971  nitrate reductase molybdenum cofactor assembly chaperone [KO:K00373]
Kvar_2438  formate dehydrogenase, alpha subunit [KO:K08348] [EC:1.17.5.3]
Kvar_2437  molybdopterin oxidoreductase Fe4S4 region [KO:K08348] [EC:1.17.5.3]
Kvar_2439  formate dehydrogenase, beta subunit [KO:K08349]
Kvar_2440  formate dehydrogenase, gamma subunit [KO:K08350]
Kvar_4698  fumarate reductase, flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
Kvar_4699  succinate dehydrogenase and fumarate reductase iron-sulfur protein [KO:K00245] [EC:1.3.5.1]
Kvar_4700  fumarate reductase subunit C [KO:K00246]
Kvar_4701  fumarate reductase D subunit [KO:K00247]
Kvar_0035  phosphoglycerate transporter [KO:K07783]
Kvar_3739  major facilitator superfamily MFS_1 [KO:K07783]
Kvar_0034  integral membrane sensor signal transduction histidine kinase [KO:K07675] [EC:2.7.13.3]
Kvar_0033  two component transcriptional regulator, LuxR family [KO:K07686]
Kvar_0036  phosphoglycerate transporter [KO:K07784]
Kvar_4171  outer membrane lipoprotein [KO:K06080]
Kvar_1414  integral membrane sensor hybrid histidine kinase [KO:K07677] [EC:2.7.13.3]
Kvar_1416  multi-sensor signal transduction histidine kinase [KO:K07676] [EC:2.7.13.3]
Kvar_1686  transcriptional regulator, LuxR family [KO:K07781]
Kvar_1415  two component transcriptional regulator, LuxR family [KO:K07687]
Kvar_0927  multi-sensor hybrid histidine kinase [KO:K07678] [EC:2.7.13.3]
Kvar_1695  two component transcriptional regulator, LuxR family [KO:K07689]
Kvar_1693  transcriptional regulator, LuxR family [KO:K07782]
Kvar_1045  carbon storage regulator, CsrA [KO:K03563]
Kvar_0611  Hpt sensor hybrid histidine kinase [KO:K07679] [EC:2.7.13.3]
Kvar_0612  two component transcriptional regulator, LuxR family [KO:K07690]
Kvar_0776  Pili assembly chaperone, N-terminal protein [KO:K07346]
Kvar_4710  Pili assembly chaperone, N-terminal protein [KO:K07346]
Kvar_2590  Pili assembly chaperone, N-terminal protein [KO:K07346]
Kvar_0775  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_0792  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_1082  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_4774  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_4711  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_2589  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_2657  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_0784  fimbrial biogenesis outer membrane usher protein [KO:K07347]
Kvar_4201  UTP-GlnB uridylyltransferase, GlnD [KO:K00990] [EC:2.7.7.59]
Kvar_1185  nitrogen regulatory protein P-II [KO:K04751]
Kvar_5046  signal transduction histidine kinase, nitrogen specific, NtrB [KO:K07708] [EC:2.7.13.3]
Kvar_5047  nitrogen metabolism transcriptional regulator, NtrC, Fis Family [KO:K07712]
Kvar_5045  glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
Kvar_1587  transcriptional regulator, NifA, Fis Family [KO:K02584]
Kvar_4857  integral membrane sensor signal transduction histidine kinase [KO:K07709] [EC:2.7.13.3]
Kvar_4856  two component, sigma54 specific, transcriptional regulator, Fis family [KO:K07713]
Kvar_4858  zinc resistance protein [KO:K07803]
Kvar_0802  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Kvar_2219  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Kvar_2870  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Kvar_0223  sodium:dicarboxylate symporter [KO:K11103]
Kvar_0487  RNA polymerase, sigma 54 subunit, RpoN [KO:K03092]
Kvar_1182  integral membrane sensor signal transduction histidine kinase [KO:K07711] [EC:2.7.13.3]
Kvar_1184  putative two component, sigma54 specific, transcriptional regulator, Fis family [KO:K07715]
Kvar_3688  ABC transporter related protein [KO:K10004] [EC:7.4.2.1]
Kvar_3687  polar amino acid ABC transporter, inner membrane subunit [KO:K10002]
Kvar_3686  polar amino acid ABC transporter, inner membrane subunit [KO:K10003]
Kvar_3685  extracellular solute-binding protein family 3 [KO:K10001]
Kvar_0358  transcriptional regulator, Crp/Fnr family [KO:K10914]
Kvar_2698  Glutaminase [KO:K01425] [EC:3.5.1.2]
Kvar_2374  cytochrome bd ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
Kvar_3207  cytochrome bd ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
Kvar_3634  cytochrome bd ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
Kvar_2373  cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
Kvar_3206  cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
Kvar_3633  cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
Kvar_3632  cyd operon protein YbgT [KO:K00424] [EC:7.1.1.7]
Kvar_0647  type I secretion outer membrane protein, TolC family [KO:K12340]
Kvar_1551  polysaccharide export protein [KO:K01991]
Kvar_1552  protein tyrosine phosphatase [KO:K25307] [EC:3.1.3.48]
Kvar_1553  capsular exopolysaccharide family [KO:K16692] [EC:2.7.10.3]
Kvar_4942  UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
Kvar_4941  nucleotide sugar dehydrogenase [KO:K02472] [EC:1.1.1.336]
Kvar_3591  Pectinesterase [KO:K01051] [EC:3.1.1.11]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
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  Title
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  Journal
Mol Microbiol 43:809-21 (2002)
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Reference
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  Title
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Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
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  Title
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  Journal
J Bacteriol 182:961-6 (2000)
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Reference
PMID:15326287
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  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
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Reference
PMID:2666399
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  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
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Reference
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  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
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Reference
PMID:10972837
  Authors
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  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
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Reference
PMID:15937169
  Authors
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  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
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Reference
PMID:15601704
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  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
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J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
PMID:17448786
  Authors
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  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
PMID:19308662
  Authors
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  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
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Reference
PMID:7751278
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  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
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J Bacteriol 177:2695-706 (1995)
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Reference
PMID:10089160
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  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
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Reference
PMID:11673427
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  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
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Reference
PMID:11889485
  Authors
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  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
DOI:10.1007/s00203-001-0393-z
Reference
PMID:12167640
  Authors
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  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
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Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
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J Bacteriol 178:611-8 (1996)
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Reference
PMID:10940023
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Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
DOI:10.1128/JB.182.17.4822-4828.2000
Reference
PMID:11807079
  Authors
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  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
DOI:10.1128/JB.184.4.1180-1186.2002
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
DOI:10.1128/JB.175.11.3259-3268.1993
Reference
PMID:9220011
  Authors
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Related
pathway
kva00190  Oxidative phosphorylation
kva00550  Peptidoglycan biosynthesis
kva00910  Nitrogen metabolism
kva02030  Bacterial chemotaxis
kva02040  Flagellar assembly
kva03070  Bacterial secretion system
KO pathway
ko02020   
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