KEGG   PATHWAY: lih00260
Entry
lih00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Limnohabitans sp. 63ED37-2
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
lih00260  Glycine, serine and threonine metabolism
lih00260

Module
lih_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:lih00260]
lih_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:lih00260]
lih_M00621  Glycine cleavage system [PATH:lih00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Limnohabitans sp. 63ED37-2 [GN:lih]
Gene
L63ED372_01632  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
L63ED372_00840  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
L63ED372_01523  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
L63ED372_00711  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
L63ED372_01522  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
L63ED372_03104  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
L63ED372_01643  glyA2; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
L63ED372_02928  Soluble hydrogenase 42 kDa subunit [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
L63ED372_01319  Soluble hydrogenase 42 kDa subunit [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
L63ED372_03186  ghrA; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
L63ED372_01081  ghrB_2; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
L63ED372_00467  ttuD; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
L63ED372_02497  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
L63ED372_00353  gpgP; Glucosyl-3-phosphoglycerate phosphatase [KO:K15634] [EC:5.4.2.11]
L63ED372_01667  Putative 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
L63ED372_00853  serC_1; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
L63ED372_00900  serC_2; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
L63ED372_01476  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
L63ED372_01298  gcvP; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
L63ED372_01300  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
L63ED372_01196  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
L63ED372_01242  lpd; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
L63ED372_01299  gcvH; Glycine cleavage system H protein [KO:K02437]
L63ED372_02002  CDP-alcohol phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
L63ED372_00265  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
L63ED372_00925  D-threonine aldolase [KO:K01753] [EC:4.3.1.18]
L63ED372_01709  Aspartate racemase [KO:K25316] [EC:5.1.1.10]
L63ED372_00835  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
L63ED372_00836  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
lih00010  Glycolysis / Gluconeogenesis
lih00020  Citrate cycle (TCA cycle)
lih00230  Purine metabolism
lih00250  Alanine, aspartate and glutamate metabolism
lih00270  Cysteine and methionine metabolism
lih00290  Valine, leucine and isoleucine biosynthesis
lih00300  Lysine biosynthesis
lih00330  Arginine and proline metabolism
lih00460  Cyanoamino acid metabolism
lih00470  D-Amino acid metabolism
lih00564  Glycerophospholipid metabolism
lih00620  Pyruvate metabolism
lih00630  Glyoxylate and dicarboxylate metabolism
lih00640  Propanoate metabolism
lih00680  Methane metabolism
lih00860  Porphyrin metabolism
lih00920  Sulfur metabolism
KO pathway
ko00260   
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