KEGG   PATHWAY: lpq02060
Entry
lpq02060                    Pathway                                
Name
Phosphotransferase system (PTS) - Lacticaseibacillus paracasei N1115
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
Pathway map
lpq02060  Phosphotransferase system (PTS)
lpq02060

Other DBs
GO: 0009401
TC: 4.A
Organism
Lacticaseibacillus paracasei N1115 [GN:lpq]
Gene
AF91_05080  phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:2.7.3.9]
AF91_05075  phosphocarrier protein HPr [KO:K02784]
AF91_03260  PTS sucrose transporter subunit IIABC [KO:K02810] [EC:2.7.1.211]
AF91_14785  PTS glucose transporter [KO:K02810] [EC:2.7.1.211]
AF91_02165  PTS beta-glucoside transporter subunit IIABC [KO:K02757] [EC:2.7.1.-]
AF91_08360  PTS beta-glucoside transporter subunit IIABC [KO:K02757] [EC:2.7.1.-]
AF91_10540  PTS beta-glucoside transporter subunit IIABC [KO:K02757] [EC:2.7.1.-]
AF91_14100  PTS mannitol transporter subunit IIA [KO:K02798] [EC:2.7.1.197]
AF91_01150  PTS mannitol transporter subunit IIABC [KO:K02800] [EC:2.7.1.197]
AF91_14110  PTS mannitol transferase subunit IIB [KO:K02800] [EC:2.7.1.197]
AF91_02350  PTS lactose transporter subunit IIA [KO:K02786] [EC:2.7.1.207]
AF91_01900  PTS lactose transporter subunit IIA [KO:K02786] [EC:2.7.1.207]
AF91_01890  PTS lactose transporter subunit IIB [KO:K02788] [EC:2.7.1.207]
AF91_02340  PTS lactose transporter subunit IIB [KO:K02788] [EC:2.7.1.207]
AF91_13245  PTS cellobiose transporter subunit IIA [KO:K02759] [EC:2.7.1.196 2.7.1.205]
AF91_08525  PTS cellobiose transporter subunit IIA [KO:K02759] [EC:2.7.1.196 2.7.1.205]
AF91_01495  PTS cellobiose transporter subunit IIA [KO:K02759] [EC:2.7.1.196 2.7.1.205]
AF91_03365  PTS lactose transporter subunit IIA [KO:K02759] [EC:2.7.1.196 2.7.1.205]
AF91_00835  PTS lactose transporter subunit IIA [KO:K02759] [EC:2.7.1.196 2.7.1.205]
AF91_13800  PTS cellobiose transporter subunit IIA [KO:K02759] [EC:2.7.1.196 2.7.1.205]
AF91_04975  PTS cellobiose transporter subunit IIA [KO:K02759] [EC:2.7.1.196 2.7.1.205]
AF91_13250  PTS sugar transporter [KO:K02760] [EC:2.7.1.196 2.7.1.205]
AF91_01505  PTS lactose transporter subunit IIB [KO:K02760] [EC:2.7.1.196 2.7.1.205]
AF91_00830  PTS lactose transporter subunit IIB [KO:K02760] [EC:2.7.1.196 2.7.1.205]
AF91_13795  PTS sugar transporter [KO:K02760] [EC:2.7.1.196 2.7.1.205]
AF91_04970  PTS sugar transporter [KO:K02760] [EC:2.7.1.196 2.7.1.205]
AF91_10825  PTS cellobiose transporter subunit IIB [KO:K02760] [EC:2.7.1.196 2.7.1.205]
AF91_13285  PTS cellobiose transporter subunit IIC [KO:K02761]
AF91_00680  PTS cellobiose transporter subunit IIC [KO:K02761]
AF91_01500  PTS lactose transporter subunit IIC [KO:K02761]
AF91_03345  PTS cellobiose transporter subunit IIC [KO:K02761]
AF91_13785  PTS cellobiose transporter subunit IIC [KO:K02761]
AF91_00825  PTS lactose transporter subunit IIC [KO:K02761]
AF91_04985  celD; PTS cellobiose transporter subunit IIC [KO:K02761]
AF91_00805  PTS fructose transporter subunit IIA [KO:K02793] [EC:2.7.1.191]
AF91_15095  hypothetical protein [KO:K02793] [EC:2.7.1.191]
AF91_13565  PTS mannose transporter subunit IID [KO:K02794] [EC:2.7.1.191]
AF91_15100  PTS sugar transporter subunit IIC [KO:K02794] [EC:2.7.1.191]
AF91_15385  GntR family transcriptional regulator [KO:K02794] [EC:2.7.1.191]
AF91_13855  PTS mannose transporter subunit IIAB [KO:K02794] [EC:2.7.1.191]
AF91_01280  PTS N-acetylgalactosamine transporter subunit IIA [KO:K02795]
AF91_00795  PTS fructose transporter subunit IIC [KO:K02795]
AF91_01110  PTS sorbose transporter subunit IIC [KO:K02795]
AF91_13575  PTS sorbose transporter subunit IIC [KO:K02795]
AF91_13850  PTS alpha-glucoside transporter subunit IIBC [KO:K02795]
AF91_15110  PTS sorbose transporter subunit IIC [KO:K02795]
AF91_00800  PTS fructose transporter subunit IID [KO:K02796]
AF91_01285  PTS N-acetylglucosamine transporter subunit IIABC [KO:K02796]
AF91_13570  PTS mannose transporter subunit IID [KO:K02796]
AF91_13845  PTS mannose transporter subunit IID [KO:K02796]
AF91_15105  PTS trehalose transporter subunit IIBC [KO:K02796]
AF91_01295  PTS N-acetylglucosamine transporter subunit IIBC [KO:K19506] [EC:2.7.1.-]
AF91_01100  PTS fructose transporter subunit IIA [KO:K02744] [EC:2.7.1.-]
AF91_13365  PTS fructose transporter subunit IIA [KO:K02744] [EC:2.7.1.-]
AF91_15400  hypothetical protein [KO:K02744] [EC:2.7.1.-]
AF91_13380  PTS N-acetylgalactosamine transporter subunit IIB [KO:K02745] [EC:2.7.1.-]
AF91_13375  PTS N-acetylgalactosamine transporter subunit IIC [KO:K02746]
AF91_13370  PTS N-acetylglucosamine transporter subunit IIBC [KO:K02747]
AF91_15390  PTS sucrose transporter subunit IIBC [KO:K10985]
AF91_15395  PTS N-acetylgalactosamine transporter subunit IID [KO:K10986]
AF91_09370  PTS glucose transporter subunit IIABC [KO:K02781] [EC:2.7.1.198]
AF91_13315  PTS galactitol transporter subunit IIA [KO:K02773] [EC:2.7.1.200]
AF91_12880  PTS galactitol transporter subunit IIA [KO:K02773] [EC:2.7.1.200]
AF91_13225  PTS galactitol transporter subunit IIA [KO:K02773] [EC:2.7.1.200]
AF91_13220  PTS galactitol transporter subunit IIB [KO:K02774] [EC:2.7.1.200]
AF91_13215  gatC; PTS galactitol transporter subunit IIC [KO:K02775]
AF91_13305  PTS galactitol transporter subunit IIC [KO:K02775]
AF91_02390  PTS sugar transporter subunit IIA [KO:K20112] [EC:2.7.1.204]
AF91_02395  PTS fructose transporter subunit IIB [KO:K20113] [EC:2.7.1.204]
AF91_02400  PTS glucitol transporter subunit IIA [KO:K20114]
AF91_01050  PTS ascorbate transporter subunit IIB [KO:K02822] [EC:2.7.1.194]
AF91_01055  PTS beta-glucoside transporter subunit IIBC [KO:K03475]
AF91_07155  PTS fructose transporter subunit IIC [KO:K02770] [EC:2.7.1.202]
AF91_07150  phosphofructokinase [KO:K00882] [EC:2.7.1.56]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00354  D-Fructose 1,6-bisphosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
Related
pathway
lpq00051  Fructose and mannose metabolism
KO pathway
ko02060   
LinkDB

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