KEGG   PATHWAY: lsq00260
Entry
lsq00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Lucilia sericata (common green bottle fly)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
lsq00260  Glycine, serine and threonine metabolism
lsq00260

Module
lsq_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:lsq00260]
lsq_M00621  Glycine cleavage system [PATH:lsq00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Lucilia sericata (common green bottle fly) [GN:lsq]
Gene
119599904  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
119605479  serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
119608143  serine--pyruvate aminotransferase, mitochondrial [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
119609225  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
119605807  LOW QUALITY PROTEIN: glycerate kinase [KO:K11529] [EC:2.7.1.165]
119615966  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
119601925  LOW QUALITY PROTEIN: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase-like [KO:K01834] [EC:5.4.2.11]
119603447  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase-like isoform X1 [KO:K01834] [EC:5.4.2.11]
119601053  probable phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
119606321  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
119616056  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
119613164  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
119600641  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
119601250  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
119616001  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
119608908  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
119613453  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
119612868  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
119602832  glycine cleavage system H protein, mitochondrial [KO:K02437]
119610684  D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
119612252  alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119613327  putative aldehyde dehydrogenase family 7 member A1 homolog [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
119613729  LOW QUALITY PROTEIN: sarcosine dehydrogenase, mitochondrial-like [KO:K00314] [EC:1.5.8.3]
119614622  sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
119605752  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
119612368  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
119599705  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
119614852  LOW QUALITY PROTEIN: L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
lsq00010  Glycolysis / Gluconeogenesis
lsq00020  Citrate cycle (TCA cycle)
lsq00230  Purine metabolism
lsq00250  Alanine, aspartate and glutamate metabolism
lsq00270  Cysteine and methionine metabolism
lsq00290  Valine, leucine and isoleucine biosynthesis
lsq00330  Arginine and proline metabolism
lsq00470  D-Amino acid metabolism
lsq00564  Glycerophospholipid metabolism
lsq00600  Sphingolipid metabolism
lsq00620  Pyruvate metabolism
lsq00630  Glyoxylate and dicarboxylate metabolism
lsq00640  Propanoate metabolism
lsq00860  Porphyrin metabolism
lsq00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system