KEGG   PATHWAY: lsv00480
Entry
lsv00480                    Pathway                                
Name
Glutathione metabolism - Lactuca sativa (garden lettuce)
Class
Metabolism; Metabolism of other amino acids
Pathway map
lsv00480  Glutathione metabolism
lsv00480

Module
lsv_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:lsv00480]
Other DBs
GO: 0006749
Organism
Lactuca sativa (garden lettuce) [GN:lsv]
Gene
111892592  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111883841  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111908087  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
111904171  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
111913051  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
111909725  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
111909669  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
111909254  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
111881627  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
111901119  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
111901120  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
111888385  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
111888389  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
111888402  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
111888287  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
111888317  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
111898452  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111890928  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
111890938  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
111889760  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
111892080  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
111896148  glutathione S-transferase PARB [KO:K00799] [EC:2.5.1.18]
111892846  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111893115  glutathione S-transferase L3 isoform X1 [KO:K00799] [EC:2.5.1.18]
111890335  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111890337  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111921220  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
111920111  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111920124  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111920125  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111920126  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111920134  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111920135  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111912436  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111912446  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111912447  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111912448  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111912450  glutathione S-transferase U25 [KO:K00799] [EC:2.5.1.18]
111912466  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111912467  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111912475  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111915975  uncharacterized protein LOC111915975 [KO:K00799] [EC:2.5.1.18]
111915976  uncharacterized protein LOC111915976 [KO:K00799] [EC:2.5.1.18]
111916028  uncharacterized protein LOC111916028 [KO:K00799] [EC:2.5.1.18]
111913416  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
111906534  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
111900386  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111900387  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111900388  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111900395  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111900396  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111900398  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111900400  LOW QUALITY PROTEIN: glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111900404  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111900433  LOW QUALITY PROTEIN: glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111904252  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
111917048  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111917049  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
111917052  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111921849  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111911156  uncharacterized protein LOC111911156 [KO:K00799] [EC:2.5.1.18]
111880263  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
111887004  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111888975  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111888985  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111883404  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111915884  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
111881189  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
111916042  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
111921843  isocitrate dehydrogenase [NADP], chloroplastic [KO:K00031] [EC:1.1.1.42]
111883074  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
111918769  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111876659  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111898143  glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111889827  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111900469  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111891248  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
111920824  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
111908098  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
111900383  glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
111901139  glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
111901140  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
111886371  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
111880404  1-Cys peroxiredoxin PER1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
111888877  spermine synthase [KO:K00797] [EC:2.5.1.16]
111918009  spermine synthase [KO:K00797] [EC:2.5.1.16]
111913711  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
111903682  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
111876315  spermine synthase [KO:K00797] [EC:2.5.1.16]
111895628  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
111899201  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
111897078  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
111897082  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
111897699  L-ascorbate peroxidase 3 isoform X1 [KO:K00434] [EC:1.11.1.11]
111915448  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
111915449  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
111909485  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
111915410  LOW QUALITY PROTEIN: probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
111902014  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
111897079  LOW QUALITY PROTEIN: L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
111882573  L-ascorbate peroxidase 2, cytosolic isoform X1 [KO:K00434] [EC:1.11.1.11]
111883147  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
111884264  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
111918906  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111882479  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111888996  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
111896236  uncharacterized protein LOC111896236 [KO:K10808] [EC:1.17.4.1]
111876578  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
111877717  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
lsv00220  Arginine biosynthesis
lsv00250  Alanine, aspartate and glutamate metabolism
lsv00270  Cysteine and methionine metabolism
lsv00430  Taurine and hypotaurine metabolism
lsv00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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