Entry Name ABC transporters - Mycobacterium tuberculosis variant africanum
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Mycobacterium tuberculosis variant africanum [GN:
maf ]
Gene MAF_24130 cysT; putative sulfate-transport integral membrane protein ABC transporter CYST [KO:K02046 ]
MAF_24120 cysW; putative sulfate-transport integral membrane protein ABC transporter CYSW [KO:K02047 ]
MAF_24110 cysA1; putative sulfate-transport ATP-binding protein ABC transporter CYSA1 [KO:K02045 ] [EC:7.3.2.3 ]
MAF_18800 modB; putative molbdenum-transport integral membrane protein ABC transporter MODB [KO:K02018 ]
MAF_18810 modC; putative molybdenum-transport ATP-binding protein ABC transporter MODC [KO:K02017 ] [EC:7.3.2.5 ]
MAF_37720 proX; putative osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX [KO:K05845 ]
MAF_37690 proZ; putative osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ [KO:K05846 ]
MAF_37700 proW; putative osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW [KO:K05846 ]
MAF_37710 proV; putative osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV [KO:K05847 ] [EC:7.6.2.9 ]
MAF_20530 putative sugar-transport ATP-binding protein ABC transporter [KO:K10112 ] [EC:7.5.2.-]
MAF_12570 sugC; putative sugar-transport ATP-binding protein ABC transporter SUGC [KO:K10112 ] [EC:7.5.2.-]
MAF_12550 sugA; putative sugar-transport integral membrane protein ABC transporter SUGA [KO:K10237 ]
MAF_12560 sugB; putative sugar-transport integral membrane protein ABC transporter SUGB [KO:K10238 ]
MAF_01740 lprK; putative MCE-family lipoprotein LprK (MCE-family lipoprotein Mce1E) [KO:K02067 ]
MAF_06000 lprL; putative MCE-family lipoprotein LPRL (MCE-family lipoprotein MCE2E) [KO:K02067 ]
MAF_35080 lprN; putative MCE-family lipoprotein LPRN (MCE-family lipoprotein MCE4E) [KO:K02067 ]
MAF_01680 yrbE1A; conserved hypothetical integral membrane protein YrbE1A [KO:K02066 ]
MAF_01690 yrbE1B; conserved hypothetical integral membrane protein YrbE1B [KO:K02066 ]
MAF_05940 yrbE2A; conserved hypothetical integral membrane protein YRBE2A [KO:K02066 ]
MAF_05950 yrbE2B; conserved hypothetical integral membrane protein YRBE2B [KO:K02066 ]
MAF_35130 yrbE4B; conserved hypothetical integral membrane protein YRBE4B [KO:K02066 ]
MAF_35140 yrbE4A; conserved hypothetical integral membrane protein YRBE4A [KO:K02066 ]
MAF_06640 mkl; putative ribonucleotide-transport ATP-binding protein ABC transporter MKL [KO:K02065 ]
MAF_28380 ugpB; putative Sn-glycerol-3-phosphate-binding lipoprotein UGPB [KO:K05813 ]
MAF_28400 ugpA; putative Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UGPA [KO:K05814 ]
MAF_28390 ugpE; putative Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UGPE [KO:K05815 ]
MAF_28370 ugpC; putative Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UGPC [KO:K05816 ] [EC:7.6.2.10 ]
MAF_09370 pstS3; periplasmic phosphate-binding lipoprotein PSTS3 [KO:K02040 ]
MAF_09410 pstS2; periplasmic phosphate-binding lipoprotein PSTS2 [KO:K02040 ]
MAF_09430 pstS1; periplasmic phosphate-binding lipoprotein PSTS1 [KO:K02040 ]
MAF_09380 pstC2; phosphate-transport integral membrane ABC transporter PSTC2 [KO:K02037 ]
MAF_09440 pstC1; phosphate-transport integral membrane ABC transporter PSTC1 [KO:K02037 ]
MAF_09390 pstA1; putative phosphate-transport integral membrane ABC transporter PSTA1 [KO:K02038 ]
MAF_09450 pstA2; phosphate-transport integral membrane ABC transporter PSTA2 [KO:K02038 ]
MAF_08300 phoT; putative phosphate-transport ATP-binding protein ABC transporter PHOT [KO:K02036 ] [EC:7.3.2.1 ]
MAF_36730 dppA; putative periplasmic dipeptide-binding lipoprotein DPPA [KO:K15580 ]
MAF_36720 dppB; putative dipeptide-transport integral membrane protein ABC transporter DPPB [KO:K15581 ]
MAF_36710 dppC; putative dipeptide-transport integral membrane protein ABC transporter DPPC [KO:K15582 ]
MAF_13010 oppA; putative periplasmic oligopeptide-binding lipoprotein OPPA [KO:K13889 ]
MAF_13040 oppB; putative oligopeptide-transport integral membrane protein ABC transporter OPPB [KO:K13890 ]
MAF_13030 oppC; putative oligopeptide-transport integral membrane protein ABC transporter OPPC [KO:K13891 ]
MAF_13020 oppD; putative oligopeptide-transport ATP-binding protein ABC transporter OPPD [KO:K13892 ]
MAF_37980 rfbD; putative O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD [KO:K09690 ]
MAF_37960 rfbE; putative O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE [KO:K09691 ] [EC:7.5.2.14 ]
MAF_26900 putative antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter [KO:K16905 ]
MAF_26910 putative antibiotic-transport integral membrane leucine and valine rich protein ABC transporter [KO:K16906 ]
MAF_26920 putative antibiotic-transport ATP-binding protein ABC transporter [KO:K16907 ] [EC:7.6.2.-]
MAF_31080 ftsX; putative cell division protein FTSX (septation component-transport integral membrane protein ABC transporter) [KO:K09811 ]
MAF_31090 ftsE; putative cell division ATP-binding protein FTSE (septation component-transport ATP-binding protein ABC transporter) [KO:K09812 ]
MAF_13720 putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K14698 ] [EC:7.-.-.-]
MAF_13730 putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K14699 ] [EC:7.-.-.-]
MAF_01950 putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K18894 ]
MAF_12940 putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K18887 ]
MAF_16320 cydC; putative 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CYDC [KO:K16012 ]
MAF_16330 cydD; putative 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CYDD [KO:K16013 ]
MAF_18410 putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K02471 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway LinkDB All DBs
