KEGG   PATHWAY: mcc00260
Entry
mcc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Macaca mulatta (rhesus monkey)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mcc00260  Glycine, serine and threonine metabolism
mcc00260

Module
mcc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mcc00260]
mcc_M00047  Creatine pathway [PATH:mcc00260]
mcc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mcc00260]
mcc_M00555  Betaine biosynthesis, choline => betaine [PATH:mcc00260]
mcc_M00621  Glycine cleavage system [PATH:mcc00260]
mcc_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mcc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
701186  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
714433  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
699941  AGXT; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
694185  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
697521  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
694418  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
706211  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
696959  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
720615  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
714548  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
706741  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
713480  PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
706387  PSAT1; phosphoserine aminotransferase isoform X2 [KO:K00831] [EC:2.6.1.52]
715687  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
715302  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
698811  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X3 [KO:K00639] [EC:2.3.1.29]
697254  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
698093  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
704727  ALAS2; LOW QUALITY PROTEIN: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
708371  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
708468  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
100431015  AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
711820  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
708053  membrane primary amine oxidase isoform X2 [KO:K00276] [EC:1.4.3.21]
715563  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
706515  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
700494  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
717440  GCSH; glycine cleavage system H protein, mitochondrial isoform X1 [KO:K02437]
698520  LOW QUALITY PROTEIN: glycine cleavage system H protein, mitochondrial [KO:K02437]
706373  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
699250  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
713306  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
721263  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
693805  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
702749  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
714363  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
709237  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
711090  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
713289  SARDH; sarcosine dehydrogenase, mitochondrial isoform X2 [KO:K00314] [EC:1.5.8.3]
697722  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
100423684  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
696664  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
713285  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
714721  SDSL; serine dehydratase-like isoform X2 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
703426  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mcc00010  Glycolysis / Gluconeogenesis
mcc00020  Citrate cycle (TCA cycle)
mcc00230  Purine metabolism
mcc00250  Alanine, aspartate and glutamate metabolism
mcc00270  Cysteine and methionine metabolism
mcc00290  Valine, leucine and isoleucine biosynthesis
mcc00330  Arginine and proline metabolism
mcc00470  D-Amino acid metabolism
mcc00564  Glycerophospholipid metabolism
mcc00600  Sphingolipid metabolism
mcc00620  Pyruvate metabolism
mcc00630  Glyoxylate and dicarboxylate metabolism
mcc00640  Propanoate metabolism
mcc00860  Porphyrin metabolism
mcc00920  Sulfur metabolism
KO pathway
ko00260   
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