Entry
Name
B cell receptor signaling pathway - Mustela nigripes (black-footed ferret)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
mnp04662 B cell receptor signaling pathway
Ortholog table
Other DBs
Organism
Mustela nigripes (black-footed ferret) [GN:
mnp ]
Gene
132005002 CD79A; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
132004519 CD79B; B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507 ]
132014095 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
132001226 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
132024270 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
132026481 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
132004336 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
132001724 BANK1; B-cell scaffold protein with ankyrin repeats isoform X1 [KO:K26239 ]
132016503 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
131999012 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
132023704 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
132022031 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
132005175 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
132012169 LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333 ]
132026442 CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
132023653 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
132001757 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
132000809 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
132011173 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
132028693 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
132001008 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
132010495 PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
132012033 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
132025750 low affinity immunoglobulin gamma Fc region receptor II-like isoform X1 [KO:K12560 ]
132005047 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
132005048 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
132005049 leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1 [KO:K06512 ]
132005805 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
132005806 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
132005811 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
132004893 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [KO:K06512 ]
132008779 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
132005052 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
132016657 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
mnp04610 Complement and coagulation cascades
mnp04810 Regulation of actin cytoskeleton
KO pathway
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