KEGG   PATHWAY: mog00010
Entry
mog00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Methylobacterium organophilum
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
mog00010  Glycolysis / Gluconeogenesis
mog00010

Module
mog_M00002  Glycolysis, core module involving three-carbon compounds [PATH:mog00010]
mog_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:mog00010]
mog_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mog00010]
Other DBs
GO: 0006096 0006094
Organism
Methylobacterium organophilum [GN:mog]
Gene
MMB17_14180  glucokinase [KO:K00845] [EC:2.7.1.2]
MMB17_17675  glucokinase [KO:K00845] [EC:2.7.1.2]
MMB17_15445  bifunctional transaldolase/phosoglucose isomerase [KO:K13810] [EC:2.2.1.2 5.3.1.9]
MMB17_00175  class 1 fructose-bisphosphatase [KO:K03841] [EC:3.1.3.11]
MMB17_17760  glpX; class II fructose-bisphosphatase [KO:K11532] [EC:3.1.3.11 3.1.3.37]
MMB17_23700  fba; fructose-bisphosphate aldolase class II [KO:K01624] [EC:4.1.2.13]
MMB17_15765  tpiA; triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
MMB17_23715  gap; type I glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
MMB17_23705  phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
MMB17_12660  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
MMB17_20455  eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
MMB17_11590  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
MMB17_05320  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
MMB17_15335  ppdK; pyruvate, phosphate dikinase [KO:K01006] [EC:2.7.9.1]
MMB17_20440  pdhA; pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha [KO:K00161] [EC:1.2.4.1]
MMB17_20435  pyruvate dehydrogenase complex E1 component subunit beta [KO:K00162] [EC:1.2.4.1]
MMB17_20425  pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12]
MMB17_20290  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMB17_20420  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMB17_00260  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMB17_19830  methanol/ethanol family PQQ-dependent dehydrogenase [KO:K14028] [EC:1.1.2.7]
MMB17_19845  methanol dehydrogenase [cytochrome c] subunit [KO:K14029] [EC:1.1.2.7]
MMB17_00795  PQQ-dependent methanol/ethanol family dehydrogenase [KO:K00114] [EC:1.1.2.8]
MMB17_02340  aldehyde dehydrogenase family protein [KO:K00138] [EC:1.2.1.-]
MMB17_13455  AMP-binding protein [KO:K01895] [EC:6.2.1.1]
MMB17_03385  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
MMB17_00560  galactose mutarotase [KO:K01785] [EC:5.1.3.3]
MMB17_12195  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
MMB17_06840  phosphomannomutase/phosphoglucomutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
MMB17_01455  phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
mog00020  Citrate cycle (TCA cycle)
mog00030  Pentose phosphate pathway
mog00500  Starch and sucrose metabolism
mog00620  Pyruvate metabolism
mog00640  Propanoate metabolism
mog00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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