KEGG PATHWAY: moo00260

PATHWAY: moo00260

Entry

moo00260                    Pathway

Name

Glycine, serine and threonine metabolism - Microbacterium oleivorans

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

moo00260

Glycine, serine and threonine metabolism

Module

moo_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:moo00260]

moo_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:moo00260]

moo_M00621

Glycine cleavage system [PATH:moo00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Microbacterium oleivorans [GN:moo]

Gene

BWL13_00766

ask; Aspartokinase [KO:K00928] [EC:2.7.2.4]

BWL13_00769

asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BWL13_02101

hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BWL13_02099

thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]

BWL13_02100

thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]

BWL13_00389

ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

BWL13_02313

glyA1; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]

BWL13_02619

garK; Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]

BWL13_00868

gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

BWL13_01581

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BWL13_02031

serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

BWL13_01125

serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

BWL13_01732

gcvP; putative glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]

BWL13_01734

gcvT_2; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]

BWL13_01020

lpdC; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

BWL13_01322

pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

BWL13_01733

gcvH; Glycine cleavage system H protein [KO:K02437]

BWL13_00473

cbs; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

BWL13_01735

sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]

BWL13_01775

tdcB; L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]

BWL13_01428

trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]

BWL13_01427

trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721