KEGG   PATHWAY: morg04218
Entry
morg04218                   Pathway                                
Name
Cellular senescence - Microtus oregoni (creeping vole)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
morg04218  Cellular senescence
morg04218

Other DBs
GO: 0090398
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121449432  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
121435842  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
121452547  Tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
121458328  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121464335  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121438761  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121466030  Smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121461982  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
121463961  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
121463532  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121454505  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
121457865  G1/S-specific cyclin-D1 [KO:K04503]
121435389  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
121450483  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121459112  Rb1; retinoblastoma-associated protein [KO:K06618]
121460185  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
121447599  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
121460216  E2f1; transcription factor E2F1 [KO:K17454]
121448904  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
121434086  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
121432488  E2f5; transcription factor E2F5 [KO:K04682]
121447224  E2f4; transcription factor E2F4 [KO:K04682]
121464321  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121453059  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121448116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121441780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121455952  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121462841  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121448002  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121452809  Foxo1; forkhead box protein O1 [KO:K07201]
121450039  Foxo3; forkhead box protein O3 [KO:K09408]
121435589  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121464192  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
121451458  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
121443216  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
121435269  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435270  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435271  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435272  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435273  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435274  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435275  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435277  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
121435283  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435313  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435364  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435376  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435377  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435378  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435379  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
121435380  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
121435381  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
121435382  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
121435464  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
121435500  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121435594  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
121435668  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
121435669  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435693  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
121435695  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
121435698  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121466497  Kras; GTPase KRas isoform X1 [KO:K07827]
121437938  Nras; GTPase NRas [KO:K07828]
121456962  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
121457996  Rras2; ras-related protein R-Ras2 [KO:K07830]
121464286  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
121458090  Hras; GTPase HRas [KO:K02833]
121434429  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121449224  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121435875  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121462616  Tsc1; hamartin isoform X1 [KO:K07206]
121463682  Tsc2; tuberin isoform X1 [KO:K07207]
121439898  Rheb; GTP-binding protein Rheb [KO:K07208]
121448014  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121441746  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121454138  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121451034  Sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
121452823  Ccna2; cyclin-A2 [KO:K06627]
121452921  Ccna1; cyclin-A1 [KO:K06627]
121460210  Mybl2; myb-related protein B [KO:K21769]
121435935  Lin9; protein lin-9 homolog [KO:K21773]
121450075  Lin37; protein lin-37 homolog [KO:K21774]
121452125  Lin52; protein lin-52 homolog [KO:K21775]
121460863  protein lin-54 homolog isoform X1 [KO:K21776]
121440984  Lin54; protein lin-54 homolog isoform X1 [KO:K21776]
121462107  histone-binding protein RBBP4-like [KO:K10752]
121448074  Rbbp4; histone-binding protein RBBP4 [KO:K10752]
121441223  Foxm1; forkhead box protein M1 isoform X1 [KO:K09406]
121461531  Myc; myc proto-oncogene protein [KO:K04377]
121448689  Cdkn2b; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K06621]
121460179  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
121456449  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
121446373  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
121463665  Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
121453901  Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
121463336  Hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
121465543  Hipk3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
121438013  Hipk1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
121449126  Hipk4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
121435438  homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
121454539  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121446369  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121432896  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121443425  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121466018  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121459389  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121458143  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121464725  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121451646  Ets1; protein C-ets-1 isoform X1 [KO:K02678]
121456403  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
121436314  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
121461212  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121461365  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121435212  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121435574  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
121459519  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
121453354  growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
121444490  growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
121438388  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
121450635  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121455799  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
121466142  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
121444345  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
121444377  G2/mitotic-specific cyclin-B3-like [KO:K21771]
121451907  Mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
121457032  Rad50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
121451527  Nbn; nibrin [KO:K10867]
121446253  Chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
121454538  Rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
121446374  Rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
121432970  Rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
121459668  Hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
121464308  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
121451627  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
121464398  Cdc25a; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
121456180  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
121460883  Gata4; transcription factor GATA-4 isoform X1 [KO:K09183]
121449558  Traf3ip2; E3 ubiquitin ligase TRAF3IP2 isoform X1 [KO:K21124]
121450269  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121454688  Rela; transcription factor p65 isoform X1 [KO:K04735]
121460451  Il1a; interleukin-1 alpha [KO:K04383]
121439902  Il6; interleukin-6 [KO:K05405]
121459914  Igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
121446504  Serpine1; plasminogen activator inhibitor 1 [KO:K03982]
121462285  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
121446223  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
121452418  Zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753]
121432973  Zfp36l2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753]
121454953  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121446229  Trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
121465872  Trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
121454081  Capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
121435859  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
121462368  calmodulin-1 [KO:K02183]
121465992  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
121432548  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
121432747  calmodulin-like protein 3 [KO:K02183]
121432887  Calm2; calmodulin-2 [KO:K02183]
121434435  Calm1; calmodulin-1 [KO:K02183]
121449209  Calm3; calmodulin-3 [KO:K02183]
121461739  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121453244  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121438600  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121459616  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
121451753  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
121440145  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
121460203  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
121447567  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121434994  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
121440758  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121433763  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
121435401  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121452943  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
121451521  ADP/ATP translocase 2-like [KO:K05863]
121451756  ADP/ATP translocase 2 [KO:K05863]
121444701  ADP/ATP translocase 2 [KO:K05863]
121433765  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
121441648  ADP/ATP translocase 2 [KO:K05863]
121435628  ADP/ATP translocase 2-like [KO:K05863]
121452705  Ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
121444742  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
121456504  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
121438629  voltage-dependent anion-selective channel protein 2 [KO:K15040]
121435027  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
121462373  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121450910  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
morg04020  Calcium signaling pathway
morg04068  FoxO signaling pathway
morg04110  Cell cycle
morg04115  p53 signaling pathway
morg04150  mTOR signaling pathway
KO pathway
ko04218   
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