KEGG   PATHWAY: msam04512
Entry
msam04512                   Pathway                                
Name
ECM-receptor interaction - Micropterus salmoides (largemouth bass)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
msam04512  ECM-receptor interaction
msam04512

Other DBs
GO: 0005201
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119916117  col1a1b; collagen, type I, alpha 1b [KO:K06236]
119882269  col1a1a; collagen, type I, alpha 1a isoform X1 [KO:K06236]
119906985  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
119905271  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
119885994  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
119903684  collagen alpha-2(IV) chain-like [KO:K06237]
119882595  col4a4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
119904231  collagen alpha-1(IV) chain-like [KO:K06237]
119883277  col4a3; collagen alpha-5(IV) chain [KO:K06237]
119911864  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
119912490  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
119902144  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
119902146  collagen alpha-1(IV) chain-like [KO:K06237]
119903447  collagen alpha-3(VI) chain-like [KO:K06238]
119903451  col6a3; LOW QUALITY PROTEIN: uncharacterized protein col6a3 [KO:K06238]
119904002  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
119898157  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
119898159  collagen alpha-6(VI) chain-like [KO:K06238]
119898160  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain-like [KO:K06238]
119902466  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
119902468  col6a1; collagen alpha-1(VI) chain [KO:K06238]
119897914  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
119917279  col9a1b; collagen, type IX, alpha 1b isoform X1 [KO:K08131]
119905276  col9a3; collagen alpha-3(IX) chain [KO:K08131]
119906861  collagen alpha-1(IX) chain-like [KO:K08131]
119907132  col9a2; collagen alpha-2(IX) chain [KO:K08131]
119908545  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
119888490  LOW QUALITY PROTEIN: laminin subunit alpha-1-like [KO:K05637]
119905073  lama5; laminin subunit alpha-5 [KO:K06240]
119884657  laminin subunit alpha-5-like [KO:K06240]
119887244  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
119902074  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
119908687  lama4; laminin subunit alpha-4 [KO:K06241]
119918429  lamb1b; laminin subunit beta-1b [KO:K05636]
119893965  lamb1a; laminin subunit beta-1a [KO:K05636]
119905821  lamb2; laminin subunit beta-2 [KO:K06243]
119905820  lamb2l; laminin subunit beta-2 [KO:K06243]
119885778  laminin subunit beta-3-like [KO:K06244]
119894266  lamb4; laminin subunit beta-4 [KO:K06245]
119902725  lamc1; laminin subunit gamma-1 [KO:K05635]
119902729  lamc2; laminin subunit gamma-2 [KO:K06246]
119914248  lamc3; laminin subunit gamma-3 [KO:K06247]
119915559  chad; chondroadherin [KO:K06248]
119894201  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
119909012  thbs1b; thrombospondin-1 [KO:K16857]
119910151  thrombospondin-1-like [KO:K16857]
119881877  LOW QUALITY PROTEIN: thrombospondin-3a-like [KO:K04659]
119915927  thrombospondin-2-like [KO:K04659]
119891164  thrombospondin-4-B-like [KO:K04659]
119898227  thrombospondin-3a-like [KO:K04659]
119917225  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
119884601  thrombospondin-4-B-like [KO:K04659]
119900527  cartilage oligomeric matrix protein [KO:K04659]
119914796  thbs4b; thrombospondin-4-B [KO:K04659]
119903882  fn1a; LOW QUALITY PROTEIN: fibronectin 1a [KO:K05717]
119890165  fn1b; fibronectin 1b [KO:K05717]
119882807  vtna; vitronectin a [KO:K06251]
119895608  vtnb; vitronectin b [KO:K06251]
119897774  tnxba; tenascin [KO:K06252]
119912223  uncharacterized protein LOC119912223 [KO:K06252]
119892162  tnc; tenascin isoform X1 [KO:K06252]
119907597  tenascin isoform X1 [KO:K06252]
119902118  tnr; tenascin-R [KO:K06252]
119902121  tnn; tenascin-N isoform X1 [KO:K06252]
119914597  zmp:0000000846; tenascin isoform X1 [KO:K06252]
119898931  LOW QUALITY PROTEIN: nephronectin-like [KO:K06824]
119891691  fras1; LOW QUALITY PROTEIN: extracellular matrix protein FRAS1 [KO:K23379]
119884098  extracellular matrix protein FRAS1-like [KO:K23379]
119887354  extracellular matrix protein FRAS1-like [KO:K23379]
119882264  frem2b; FRAS1-related extracellular matrix protein 2b [KO:K23380]
119900201  frem1b; FRAS1-related extracellular matrix protein 1b isoform X1 [KO:K23380]
119913096  frem1a; FRAS1-related extracellular matrix protein 1a isoform X1 [KO:K23380]
119895884  frem2a; FRAS1-related extracellular matrix protein 2a [KO:K23380]
119893265  vwf; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
119905925  agrn; agrin isoform X1 [KO:K06254]
119905157  hspg2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
119914469  itga1; integrin alpha-1 [KO:K06480]
119892304  integrin alpha-2-like [KO:K06481]
119896058  itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
119896009  integrin alpha-3-like isoform X1 [KO:K06482]
119915524  itga3b; integrin alpha-3b [KO:K06482]
119904395  itga4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
119905181  itga5; integrin alpha-5 [KO:K06484]
119904101  itga6a; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
119902203  integrin alpha-6-like isoform X1 [KO:K06485]
119889398  integrin alpha-6-like [KO:K06485]
119886436  itga7; integrin alpha-7 isoform X1 [KO:K06583]
119897697  itga8; integrin alpha-8 [KO:K06584]
119917084  itga9; integrin alpha-9 [KO:K06585]
119897562  itga10; integrin alpha-10 [KO:K06586]
119890350  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
119894419  itga11b; integrin alpha-11 isoform X1 [KO:K06587]
119903768  itgav; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
119918606  integrin alpha-V-like [KO:K06487]
119906664  integrin beta-1-like isoform X1 [KO:K05719]
119901714  integrin beta-1-like [KO:K05719]
119916149  integrin beta-3-like [KO:K06493]
119892793  integrin beta-3-like [KO:K06493]
119894705  integrin beta-4-like [KO:K06525]
119915730  integrin beta-4-like [KO:K06525]
119904548  itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
119890759  itgb6; integrin beta-6 isoform X1 [KO:K06589]
119907264  itgb8; integrin beta-8 isoform X1 [KO:K06591]
119894144  cd44b; CD44 antigen isoform X1 [KO:K06256]
119886963  sdc4; syndecan-4 isoform X1 [KO:K16338]
119897113  sv2a; synaptic vesicle glycoprotein 2A [KO:K06258]
119890848  sv2ba; LOW QUALITY PROTEIN: synaptic vesicle glycoprotein 2Ba [KO:K06258]
119891098  sv2ca; synaptic vesicle glycoprotein 2Ca [KO:K06258]
119906693  synaptic vesicle glycoprotein 2A-like [KO:K06258]
119893727  sv2; synaptic vesicle glycoprotein 2B [KO:K06258]
119914793  synaptic vesicle glycoprotein 2C-like [KO:K06258]
119918408  cd36; platelet glycoprotein 4 isoform X1 [KO:K06259]
119901354  uncharacterized protein LOC119901354 [KO:K06260]
119911591  platelet glycoprotein Ib alpha chain [KO:K06261]
119892356  gp1bb; platelet glycoprotein Ib beta chain [KO:K06262]
119905318  gp9; glycoprotein IX (platelet) [KO:K06263]
119905384  dystroglycan-like [KO:K06265]
119885668  dag1; dystroglycan [KO:K06265]
119889047  hmmr; hyaluronan mediated motility receptor [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
msam04510  Focal adhesion
KO pathway
ko04512   
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