KEGG   PATHWAY: mthn00260
Entry
mthn00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mycolicibacterium thermoresistibile
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mthn00260  Glycine, serine and threonine metabolism
mthn00260

Module
mthn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mthn00260]
mthn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mthn00260]
mthn_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:mthn00260]
mthn_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mthn00260]
mthn_M00621  Glycine cleavage system [PATH:mthn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mycolicibacterium thermoresistibile [GN:mthn]
Gene
4412656_04317  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
4412656_04316  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
4412656_03186  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
4412656_03184  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
4412656_03185  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
4412656_00817  ltaE; threonine aldolase [KO:K01620] [EC:4.1.2.48]
4412656_03567  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
4412656_01833  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
4412656_00585  gpmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
4412656_01295  ghrB; phosphoglycerate dehydrogenase-like oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
4412656_01551  serA_2; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
4412656_03865  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
4412656_01497  serB2; phosphoserine phosphatase serB2 [KO:K01079] [EC:3.1.3.3]
4412656_01325  puo_1; amine oxidase [KO:K00274] [EC:1.4.3.4]
4412656_02369  puo_2; flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
4412656_02248  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
4412656_01827  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
4412656_00559  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
4412656_02243  gcvH; glycine cleavage system protein H [KO:K02437]
4412656_00527  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
4412656_03584  cbs; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
4412656_01566  mdeA_2; Cys/Met metabolism pyridoxal-phosphate-dependent enzyme [KO:K01758] [EC:4.4.1.1]
4412656_02005  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
4412656_02038  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
4412656_02037  trpB_1; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
4412656_02396  trpB_2; tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
4412656_01029  ectB; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
4412656_01030  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
4412656_01028  ectC; mannose-6-phosphate isomerase [KO:K06720] [EC:4.2.1.108]
4412656_01027  Ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mthn00010  Glycolysis / Gluconeogenesis
mthn00020  Citrate cycle (TCA cycle)
mthn00230  Purine metabolism
mthn00250  Alanine, aspartate and glutamate metabolism
mthn00270  Cysteine and methionine metabolism
mthn00290  Valine, leucine and isoleucine biosynthesis
mthn00300  Lysine biosynthesis
mthn00330  Arginine and proline metabolism
mthn00460  Cyanoamino acid metabolism
mthn00470  D-Amino acid metabolism
mthn00564  Glycerophospholipid metabolism
mthn00620  Pyruvate metabolism
mthn00630  Glyoxylate and dicarboxylate metabolism
mthn00640  Propanoate metabolism
mthn00680  Methane metabolism
mthn00860  Porphyrin metabolism
mthn00920  Sulfur metabolism
KO pathway
ko00260   
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