Entry
Name
B cell receptor signaling pathway - Myotis brandtii (Brandt's bat)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
myb04662 B cell receptor signaling pathway
Ortholog table
Other DBs
Organism
Myotis brandtii (Brandt's bat) [GN:
myb ]
Gene
106724953 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
106725568 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
106726103 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
106726515 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
102251188 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
102242001 DAPP1; dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [KO:K12229 ]
102259160 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392 ]
102239988 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860 ]
102249503 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861 ]
102256971 BANK1; B-cell scaffold protein with ankyrin repeats 1 [KO:K26239 ]
102250711 PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268 ]
102247129 PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268 ]
102252301 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099 ]
102259408 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099 ]
102246307 FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379 ]
102260808 JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
102252013 IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210 ]
102258430 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
102253405 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
102242302 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
102248290 low affinity immunoglobulin gamma Fc region receptor II [KO:K12560 ]
102249097 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
102258466 leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512 ]
102263862 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102262946 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102251669 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102259518 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102248234 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102259054 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
102258758 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102252948 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102258203 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102248488 leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512 ]
102261646 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
102247900 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102257412 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102251972 leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512 ]
102252268 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102248199 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102244423 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102246627 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102259938 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102245021 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102238801 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
106726303 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102249811 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102238779 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102264176 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102254651 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102254947 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
106723658 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102253760 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102255950 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102253455 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
102261679 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102248790 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
102251202 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102261936 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102249386 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
102259680 leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512 ]
102259096 leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512 ]
102257159 LILRA6; leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
myb04610 Complement and coagulation cascades
myb04810 Regulation of actin cytoskeleton
KO pathway
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