KEGG   PATHWAY: nal00260
Entry
nal00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Nocardiopsis alba
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
nal00260  Glycine, serine and threonine metabolism
nal00260

Module
nal_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:nal00260]
nal_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:nal00260]
nal_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:nal00260]
nal_M00621  Glycine cleavage system [PATH:nal00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Nocardiopsis alba [GN:nal]
Gene
B005_2029  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
B005_2030  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
B005_3191  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
B005_3193  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
B005_1379  threonine synthase [KO:K01733] [EC:4.2.3.1]
B005_3192  threonine synthase [KO:K01733] [EC:4.2.3.1]
B005_0816  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
B005_3296  aminotransferase class-V family protein [KO:K00600] [EC:2.1.2.1]
B005_5124  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
B005_2358  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
B005_1522  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
B005_3002  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B005_1328  putative phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
B005_1819  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
B005_5039  HAD phosphoserine phosphatase-like hydrolase, IB family protein [KO:K01079] [EC:3.1.3.3]
B005_4112  pyridine nucleotide-disulfide oxidoreductase family protein [KO:K00274] [EC:1.4.3.4]
B005_4083  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
B005_3298  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
B005_1773  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
B005_0129  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
B005_3297  gcvH; glycine cleavage system H protein [KO:K02437]
B005_5370  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
B005_1735  gbsA; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B005_4493  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
B005_1676  flavin containing amine oxidoreductase family protein [KO:K00301] [EC:1.5.3.1]
B005_2873  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
B005_3295  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
B005_5063  pyridoxal-phosphate dependent enzyme family protein [KO:K01754] [EC:4.3.1.19]
B005_5153  pyridoxal-phosphate dependent enzyme family protein [KO:K01754] [EC:4.3.1.19]
B005_3852  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
B005_3851  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
B005_2811  ectB; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
B005_2810  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
B005_2813  cupin domain protein [KO:K06720] [EC:4.2.1.108]
B005_4298  ectoine synthase family protein [KO:K06720] [EC:4.2.1.108]
B005_2939  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
nal00010  Glycolysis / Gluconeogenesis
nal00020  Citrate cycle (TCA cycle)
nal00230  Purine metabolism
nal00250  Alanine, aspartate and glutamate metabolism
nal00270  Cysteine and methionine metabolism
nal00290  Valine, leucine and isoleucine biosynthesis
nal00300  Lysine biosynthesis
nal00330  Arginine and proline metabolism
nal00460  Cyanoamino acid metabolism
nal00470  D-Amino acid metabolism
nal00564  Glycerophospholipid metabolism
nal00600  Sphingolipid metabolism
nal00620  Pyruvate metabolism
nal00630  Glyoxylate and dicarboxylate metabolism
nal00640  Propanoate metabolism
nal00680  Methane metabolism
nal00860  Porphyrin metabolism
nal00920  Sulfur metabolism
KO pathway
ko00260   
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