KEGG   PATHWAY: ncol00480
Entry
ncol00480                   Pathway                                
Name
Glutathione metabolism - Nymphaea colorata (blue-petal water lily)
Class
Metabolism; Metabolism of other amino acids
Pathway map
ncol00480  Glutathione metabolism
ncol00480

Module
ncol_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:ncol00480]
Other DBs
GO: 0006749
Organism
Nymphaea colorata (blue-petal water lily) [GN:ncol]
Gene
116263310  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
116262524  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
116249217  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
116254496  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
116265529  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
116260931  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
116250135  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
116265540  LOW QUALITY PROTEIN: puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
116249718  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
116250187  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
116261369  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
116251203  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
116251252  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
116261902  uncharacterized protein LOC116261902 [KO:K00799] [EC:2.5.1.18]
116253936  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
116254031  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
116254044  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
116254109  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
116254304  glutathione S-transferase-like isoform X4 [KO:K00799] [EC:2.5.1.18]
116254865  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
116254906  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
116255276  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
116256302  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
116256315  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
116256335  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
116245622  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
116256474  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
116256898  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
116256927  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
116267559  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
116268063  uncharacterized protein LOC116268063 [KO:K00799] [EC:2.5.1.18]
116247280  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
116248127  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
116259083  uncharacterized protein LOC116259083 [KO:K00799] [EC:2.5.1.18]
116248210  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
116248453  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
116259989  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
116254866  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
116255819  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
116255707  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
116266317  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
116264829  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
116255121  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
116268182  LOW QUALITY PROTEIN: uncharacterized protein LOC116268182 [KO:K00031] [EC:1.1.1.42]
116262497  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
116254479  6-phosphogluconate dehydrogenase, decarboxylating 1-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
116258405  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
116259057  6-phosphogluconate dehydrogenase, decarboxylating 1-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
116250089  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
116262507  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
116258086  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
116247736  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
116247763  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
116259280  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
116251448  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
116252679  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
116264432  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
116265445  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
116263208  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
116247054  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
116252509  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
116256212  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
116254643  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
116255429  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
116266532  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
116255882  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
116245954  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
116248806  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
116260421  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
116265082  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
116244989  LOW QUALITY PROTEIN: uncharacterized protein LOC116244989 [KO:K10807] [EC:1.17.4.1]
116266988  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
116250976  ribonucleoside-diphosphate reductase small chain B-like [KO:K10808] [EC:1.17.4.1]
116264132  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
116268004  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
116247188  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
ncol00220  Arginine biosynthesis
ncol00250  Alanine, aspartate and glutamate metabolism
ncol00270  Cysteine and methionine metabolism
ncol00430  Taurine and hypotaurine metabolism
ncol00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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