KEGG   PATHWAY: nmh01230
Entry
nmh01230                    Pathway                                
Name
Biosynthesis of amino acids - Neisseria meningitidis H44/76 (serogroup B)
Description
This map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module for conversion of three-carbon compounds from glyceraldehyde-3P to pyruvate [MD:M00002], together with the pathways around serine and glycine. This KEGG module is the most conserved one in the KEGG MODULE database and is found in almost all the completely sequenced genomes. The extensions are the pathways containing the reaction modules RM001, RM033, RM032, and RM002 for biosynthesis of branched-chain amino acids (left) and basic amino acids (bottom), and the pathways for biosynthesis of histidine and aromatic amino acids (top right). It is interesting to note that the so-called essential amino acids that cannot be synthesized in human and other organisms generally appear in these extensions. Furthermore, the bottom extension of basic amino acids appears to be most divergent containing multiple pathways for lysine biosynthesis and multiple gene sets for arginine biosynthesis.
Class
Pathway map
nmh01230  Biosynthesis of amino acids
nmh01230

Module
nmh_M00002  Glycolysis, core module involving three-carbon compounds [PATH:nmh01230]
nmh_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:nmh01230]
nmh_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:nmh01230]
nmh_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:nmh01230]
nmh_M00015  Proline biosynthesis, glutamate => proline [PATH:nmh01230]
nmh_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:nmh01230]
nmh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:nmh01230]
nmh_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:nmh01230]
nmh_M00021  Cysteine biosynthesis, serine => cysteine [PATH:nmh01230]
nmh_M00022  Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:nmh01230]
nmh_M00023  Tryptophan biosynthesis, chorismate => tryptophan [PATH:nmh01230]
nmh_M00024  Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:nmh01230]
nmh_M00025  Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:nmh01230]
nmh_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:nmh01230]
nmh_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:nmh01230]
nmh_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:nmh01230]
nmh_M00844  Arginine biosynthesis, ornithine => arginine [PATH:nmh01230]
Organism
Neisseria meningitidis H44/76 (serogroup B) [GN:nmh]
KO pathway
ko01230   
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