KEGG   PATHWAY: nsr01210
Entry
nsr01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Nocardia seriolae
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
nsr01210  2-Oxocarboxylic acid metabolism
nsr01210

Module
nsr_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:nsr01210]
nsr_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:nsr01210]
nsr_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:nsr01210]
nsr_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:nsr01210]
nsr_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:nsr01210]
nsr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:nsr01210]
nsr_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:nsr01210]
Organism
Nocardia seriolae [GN:nsr]
Related
pathway
nsr00020  Citrate cycle (TCA cycle)
nsr00220  Arginine biosynthesis
nsr00250  Alanine, aspartate and glutamate metabolism
nsr00260  Glycine, serine and threonine metabolism
nsr00270  Cysteine and methionine metabolism
nsr00290  Valine, leucine and isoleucine biosynthesis
nsr00300  Lysine biosynthesis
nsr00310  Lysine degradation
nsr00620  Pyruvate metabolism
nsr00640  Propanoate metabolism
nsr00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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