KEGG PATHWAY: nwh00260

PATHWAY: nwh00260

Entry

nwh00260                    Pathway

Name

Glycine, serine and threonine metabolism - Nematolebias whitei (Rio pearlfish)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

nwh00260

Glycine, serine and threonine metabolism

Module

nwh_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:nwh00260]

nwh_M00047

Creatine pathway [PATH:nwh00260]

nwh_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:nwh00260]

nwh_M00555

Betaine biosynthesis, choline => betaine [PATH:nwh00260]

nwh_M00621

Glycine cleavage system [PATH:nwh00260]

nwh_M00974

Betaine metabolism, animals, betaine => glycine [PATH:nwh00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Nematolebias whitei (Rio pearlfish) [GN:nwh]

Gene

119423531

tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]

119421092

serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]

119422114

serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

119412425

shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

119408168

agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

119415090

agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

119408157

grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]

119408998

grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

119412385

glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]

119422795

pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]

119418391

phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

119424811

pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

119416394

bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

119419138

phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

119413860

psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

119410598

psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

119421509

gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

119427038

tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]

119418167

tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]

119417060

alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

119429362

5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]

119429376

5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]

119424349

si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

119419704

mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]

119413840

gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

119417710

amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

119415376

dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

119428107

gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]

119415691

glycine cleavage system H protein, mitochondrial [KO:K02437]

119413376

D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

119425054

agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

119422919

gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

119407686

gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

119417106

chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

119430630

aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

119413898

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

119424604

dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

119411460

pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

119424550

sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

119427916

gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

119419671

cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]

119428945

cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

119407771

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

119427003

sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

119413486

L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

119414387

zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721