KEGG   PATHWAY: oau04218
Entry
oau04218                    Pathway                                
Name
Cellular senescence - Oreochromis aureus (blue tilapia)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
oau04218  Cellular senescence
oau04218

Other DBs
GO: 0090398
Organism
Oreochromis aureus (blue tilapia) [GN:oau]
Gene
116320331  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
116327679  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
116317211  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
116313325  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
116314093  transforming growth factor beta-3 proprotein-like [KO:K13377]
116326795  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
116312139  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
116312450  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116319415  TGF-beta receptor type-2-like isoform X3 [KO:K04388] [EC:2.7.11.30]
116322660  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116324976  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116323982  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
116326157  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
116330037  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
116326635  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116333654  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
116314389  cdk21; cyclin-dependent kinase 4 [KO:K02091] [EC:2.7.11.22]
116331023  G1/S-specific cyclin-D1-like [KO:K04503]
116332748  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
116328674  ccndx; cyclin Dx [KO:K10151]
116334728  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
116336265  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
116333801  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116330222  rb1; retinoblastoma-associated protein [KO:K06618]
116310451  rbl1; retinoblastoma-like protein 1 [KO:K04681]
116325518  retinoblastoma-like protein 2 isoform X1 [KO:K04681]
116318646  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
116311199  e2f1; transcription factor E2F1 [KO:K17454]
116334692  e2f2; transcription factor E2F2 isoform X2 [KO:K09389]
116315968  e2f3; transcription factor E2F3 [KO:K06620]
116329724  transcription factor E2F3 isoform X1 [KO:K06620]
116335741  transcription factor E2F5-like [KO:K04682]
116313421  e2f5; transcription factor E2F5 [KO:K04682]
116326339  e2f4; transcription factor E2F4 [KO:K04682]
116315474  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116321621  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
116327817  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116309708  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
116320408  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116321342  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
116310476  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116323500  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
116318253  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
116314245  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116331985  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
116329237  foxo1a; forkhead box protein O1-A [KO:K07201]
116336253  forkhead box protein O1-A-like [KO:K07201]
116310441  foxo6b; forkhead box protein O6b [KO:K09408]
116310765  foxo3b; forkhead box protein O3B [KO:K09408]
116318122  foxo3a; forkhead box protein O3a [KO:K09408]
116333861  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
116328712  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
116326619  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
116315242  G1/S-specific cyclin-E3-like isoform X1 [KO:K06626]
116330666  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
116325106  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
116309268  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
116315358  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116315410  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
116315411  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116321305  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116309323  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116309326  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116309447  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116309575  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
116315498  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116315562  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116333508  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116333515  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116310247  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
116328436  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116316941  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116334929  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116329369  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116317418  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116317426  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
116317719  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116335517  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116323894  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116323895  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116329859  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116329861  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116318461  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120432707  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
116312603  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116312619  major histocompatibility complex class I-related gene protein-like isoform X2 [KO:K06751]
116312622  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116312623  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116324812  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116330502  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116330534  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116330536  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116325163  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120435542  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120435543  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
120435675  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120435697  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120435715  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120435923  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120436737  major histocompatibility complex class I-related gene protein-like [KO:K06751]
120436742  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116326573  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116326653  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116332639  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116332660  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116332686  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116314860  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116315008  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116315009  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116315010  BOLA class I histocompatibility antigen, alpha chain BL3-6-like isoform X1 [KO:K06751]
116320887  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116320888  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116320890  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116320894  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116332706  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116335507  kras; GTPase KRas isoform X3 [KO:K07827]
116314581  zgc:55558 [KO:K07827]
116327189  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116332738  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
116327855  mrasa; ras-related protein M-Ras [KO:K07831]
116333285  GTPase HRas [KO:K02833]
116321465  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116322356  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116311852  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
116313841  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116325758  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116324075  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
116319602  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
116330594  tsc2; tuberin isoform X1 [KO:K07207]
116333901  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
116313383  rheb; GTP-binding protein Rheb [KO:K07208]
116317401  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
116333805  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116324422  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116318772  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
116322843  ccna2; cyclin-A2 [KO:K06627]
116311927  ccna1; cyclin-A1 [KO:K06627]
116327014  mybl2b; v-myb avian myeloblastosis viral oncogene homolog-like 2b [KO:K21769]
116310721  lin9; protein lin-9 homolog [KO:K21773]
116319819  lin37; protein lin-37 homolog isoform X1 [KO:K21774]
116322334  lin52; protein lin-52 homolog [KO:K21775]
116321334  tesmin; spexin prohormone 2 isoform X1 [KO:K21776]
116315917  lin54; protein lin-54 homolog [KO:K21776]
116322346  histone-binding protein RBBP4 [KO:K10752]
116319097  rbb4l; histone-binding protein RBBP7 [KO:K10752]
116320485  rbbp4; histone-binding protein RBBP4 [KO:K10752]
116330134  forkhead box protein M1-like [KO:K09406]
116318605  forkhead box protein M1 isoform X1 [KO:K09406]
120434057  forkhead box protein M1-like isoform X1 [KO:K09406]
116325477  forkhead box protein M1-like isoform X1 [KO:K09406]
116317109  mych; myelocytomatosis oncogene homolog [KO:K04377]
116335970  myca; transcriptional regulator Myc-A [KO:K04377]
116314968  transcriptional regulator Myc-2-like isoform X2 [KO:K04377]
116336464  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
116310388  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
116326437  rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
116336021  fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362]
116309402  hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
116333700  hipk3b; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
116322030  hipk1a; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
116319093  hipk3a; homeodomain-interacting protein kinase 3a [KO:K08826] [EC:2.7.11.1]
116331468  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
120436198  homeodomain-interacting protein kinase 2-like [KO:K08826] [EC:2.7.11.1]
116326549  hipk1b; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
120443419  homeodomain-interacting protein kinase 3-like [KO:K08826] [EC:2.7.11.1]
116327630  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
116322661  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
116328917  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
116335818  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116312749  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116326054  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
116331070  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
116326184  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116310020  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
116319019  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
116333371  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116314562  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116323288  ets1; protein C-ets-1 isoform X1 [KO:K02678]
116331556  ETS1-related protein isoform X1 [KO:K02678]
116328614  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116325201  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116315613  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
116309701  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
116317384  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116323199  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
116323203  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
116312555  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
116326502  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
116333084  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116333094  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
116334429  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
116310530  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
116318017  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
116324900  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
116324911  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
116314321  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
116333057  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
116332176  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
116324922  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
116334318  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
116322107  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
116314742  double-strand break repair protein MRE11-like isoform X1 [KO:K10865]
116314755  LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like [KO:K10865]
116325328  DNA repair protein RAD50-like [KO:K10866] [EC:3.6.-.-]
116331797  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
116315684  nbn; nibrin [KO:K10867]
116330374  atm; serine-protein kinase ATM isoform X2 [KO:K04728] [EC:2.7.11.1]
116311592  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
116332343  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
116322681  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
116331712  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
116330772  checkpoint protein HUS1 [KO:K10903]
120436911  checkpoint protein HUS1-like [KO:K10903]
116318070  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
116313090  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
116335506  sqstm1; sequestosome-1 [KO:K14381]
116310708  gata4; transcription factor GATA-4 [KO:K09183]
116317257  uncharacterized protein LOC116317257 [KO:K21124]
116331063  traf3ip2l; uncharacterized protein traf3ip2l [KO:K21124]
116326103  uncharacterized protein LOC116326103 isoform X1 [KO:K21124]
116329661  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116335817  rela; transcription factor p65 isoform X1 [KO:K04735]
116311957  interleukin-6-like [KO:K05405]
120432748  C-X-C motif chemokine 6-like [KO:K10030]
120433204  permeability factor 2-like isoform X1 [KO:K10030]
120433206  growth-regulated alpha protein-like [KO:K10030]
116325991  permeability factor 2-like isoform X1 [KO:K10030]
120439103  interleukin-8-like [KO:K10030]
116327030  interleukin-8-like [KO:K10030]
116327040  growth-regulated alpha protein-like [KO:K10030]
116327041  growth-regulated alpha protein-like [KO:K10030]
116327043  permeability factor 2-like [KO:K10030]
116318660  insulin-like growth factor-binding protein 3 [KO:K10138]
116314525  igfbp3; insulin-like growth factor-binding protein 3 isoform X2 [KO:K10138]
116324065  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
116324506  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
116332504  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
116326443  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
116321315  zfp36l2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753]
116321811  mRNA decay activator protein ZFP36L1 [KO:K18753]
116310330  zfp36l1a; mRNA decay activator protein ZFP36L1a [KO:K18753]
116322859  zgc:114130; mRNA decay activator protein ZFP36L1 isoform X1 [KO:K18753]
116328943  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
116324683  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
116332470  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
116322853  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
116333975  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116311103  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116317687  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116318561  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116330628  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116330629  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116313244  calpain-2 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116313245  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116314133  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
116314147  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
116314341  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
116317696  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
116317707  capn8; LOW QUALITY PROTEIN: calpain-8 [KO:K03853] [EC:3.4.22.53]
116317874  capn2l; LOW QUALITY PROTEIN: calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
116318507  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
116321311  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
116315545  calmodulin-1 [KO:K02183]
116327766  calml4b; calmodulin-like protein 4 [KO:K02183]
116324008  calml4a; calmodulin-like protein 4a [KO:K02183]
116325320  calm1a; calmodulin-1a [KO:K02183]
116314721  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
116321522  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
116329454  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116317864  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
116336221  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116321104  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
116316241  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
116324831  calcineurin subunit B type 1 [KO:K06268]
120437992  calcineurin subunit B type 1-like [KO:K06268]
116315340  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
116326767  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
116322014  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116319449  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
116315097  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
116314686  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
116326862  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
116313940  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X3 [KO:K04958]
116326605  inositol 1,4,5-trisphosphate receptor type 1 isoform X5 [KO:K04958]
116335542  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
116310193  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
116336149  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
116330143  slc25a4; ADP/ATP translocase 1 [KO:K05863]
116324654  slc25a5; ADP/ATP translocase 2 [KO:K05863]
116335298  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
116315794  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116327494  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
116309854  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116311014  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116313159  zgc:56235; voltage-dependent anion-selective channel protein 2 [KO:K15041]
116314156  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
oau04020  Calcium signaling pathway
oau04068  FoxO signaling pathway
oau04110  Cell cycle
oau04115  p53 signaling pathway
oau04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

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