KEGG   PATHWAY: oga04612
Entry
oga04612                    Pathway                                
Name
Antigen processing and presentation - Otolemur garnettii (small-eared galago)
Class
Organismal Systems; Immune system
Pathway map
oga04612  Antigen processing and presentation
oga04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100945607  IFNG; interferon gamma [KO:K04687]
100963613  TNF; tumor necrosis factor [KO:K03156]
100943511  PSME1; proteasome activator complex subunit 1 [KO:K06696]
100943831  PSME2; proteasome activator complex subunit 2 [KO:K06697]
100963968  proteasome activator complex subunit 2 [KO:K06697]
100951220  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
100945458  heat shock 70 kDa protein 1 [KO:K03283]
100959513  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
100956095  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100945147  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100946722  heat shock 70 kDa protein 1 [KO:K03283]
100945393  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
100944135  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
100954869  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
100959852  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100961793  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
100952503  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
100957517  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100956897  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
100959427  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100946825  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
100947452  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
100958806  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
100952177  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100952822  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751]
100954387  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
100953138  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
100946481  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
100954656  CANX; calnexin [KO:K08054]
100943555  B2M; beta-2-microglobulin [KO:K08055]
100944942  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100942739  CALR; calreticulin [KO:K08057]
100954043  calreticulin-like [KO:K08057]
100965502  TAPBP; tapasin isoform X2 [KO:K08058]
100966979  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
105886923  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100940392  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
100964607  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
100964288  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
100961495  LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 3DS1 [KO:K07980]
100944166  LOW QUALITY PROTEIN: putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
100962661  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100964977  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100954911  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100961610  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
100963176  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100965487  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
105888418  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100954597  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100960147  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100962147  NKG2-C type II integral membrane protein [KO:K24233]
100964543  NKG2-C type II integral membrane protein-like [KO:K24233]
100963813  NKG2-C type II integral membrane protein-like [KO:K24233]
100963497  NKG2-C type II integral membrane protein-like [KO:K24233]
100965478  LOW QUALITY PROTEIN: natural killer cells antigen CD94-like [KO:K06516]
100952279  natural killer cells antigen CD94-like [KO:K06516]
100965794  natural killer cells antigen CD94-like [KO:K06516]
100962700  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
100953335  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
100952002  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
100960158  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100961105  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
105886937  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100940711  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
100957117  HLA class II histocompatibility antigen, DRB1-1 beta chain isoform X1 [KO:K06752]
100957422  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100957736  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
100959019  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
100959331  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100966668  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
100956803  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
100941395  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
100963673  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100958924  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100950667  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
100953378  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
100948778  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
100943495  RFX5; DNA-binding protein RFX5 [KO:K08061]
100966810  RFXANK; DNA-binding protein RFXANK [KO:K08062]
100944066  RFXAP; regulatory factor X-associated protein [KO:K08063]
100964324  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100940502  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
100948366  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
100966712  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
oga03050  Proteasome
oga04650  Natural killer cell mediated cytotoxicity
oga04660  T cell receptor signaling pathway
KO pathway
ko04612   
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