KEGG   PATHWAY: oro04714
Entry
oro04714                    Pathway                                
Name
Thermogenesis - Odobenus rosmarus divergens (Pacific walrus)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
oro04714  Thermogenesis
oro04714

Other DBs
GO: 1990845
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101386439  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101364060  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
105757053  neuroendocrine secretory protein 55 [KO:K04632]
101379158  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101365382  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101368682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101374313  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101380824  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101373816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101377421  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101370350  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101364108  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101363792  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
101379936  ADCY10; adenylate cyclase type 10 isoform X2 [KO:K11265] [EC:4.6.1.1]
101367408  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101383001  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101383024  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101383806  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101385783  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101376293  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101381943  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101385675  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101384862  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
101368160  PRDM16; PR domain zinc finger protein 16 [KO:K22410] [EC:2.1.1.367]
101370092  ZNF516; zinc finger protein 516 [KO:K22411]
101371349  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
101370226  UCP1; mitochondrial brown fat uncoupling protein 1 isoform X1 [KO:K08769]
101375149  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
101366569  KDM3B; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
101379289  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
101383466  SMARCA4; transcription activator BRG1 isoform X2 [KO:K11647] [EC:5.6.2.-]
101375368  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
101363225  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
101377867  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
101372302  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
101386898  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
101367574  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3-like [KO:K11650]
101385991  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
101365279  LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like [KO:K11651]
101379696  LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like [KO:K11651]
101379571  SMARCE1; LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
101375328  ACTB; actin, cytoplasmic 1 isoform X2 [KO:K05692]
101368326  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
101378343  ACTL6B; actin-like protein 6B [KO:K11652]
101369830  ARID1B; AT-rich interactive domain-containing protein 1B [KO:K11653]
101373123  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
101368115  DPF1; zinc finger protein neuro-d4 isoform X2 [KO:K22198]
101366195  DPF3; zinc finger protein DPF3 [KO:K22198]
101370284  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101374728  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101378651  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101377143  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101377430  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101382259  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101382558  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101364106  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
101374034  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101376010  SIRT6; NAD-dependent protein deacetylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
101373782  FGF21; fibroblast growth factor 21 [KO:K22429]
101378628  PLIN1; perilipin-1 [KO:K08768]
101384261  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101376822  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
101365680  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
101379000  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101372712  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101372153  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101383756  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
101374600  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101364224  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X2 [KO:K07200]
101369816  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
101380721  GCG; glucagon [KO:K05259]
101366019  bone morphogenetic protein 8B [KO:K16622]
105757543  BMP8A; bone morphogenetic protein 8A [KO:K16622]
101365494  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
101368657  NPPA; natriuretic peptides A [KO:K12334]
101368958  NPPB; natriuretic peptides B [KO:K12335]
101384059  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101381093  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
101385162  KLB; beta-klotho [KO:K22404]
101364849  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101363142  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
101362094  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101385114  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101369947  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101367134  GTPase HRas-like [KO:K02833]
101372786  HRAS; GTPase HRas isoform X1 [KO:K02833]
101370458  KRAS; GTPase KRas isoform X2 [KO:K07827]
101363525  NRAS; GTPase NRas [KO:K07828]
101384669  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
101362329  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
101375077  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X3 [KO:K04373] [EC:2.7.11.1]
101374068  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X3 [KO:K04373] [EC:2.7.11.1]
101363167  TSC1; hamartin isoform X2 [KO:K07206]
101371494  TSC2; tuberin isoform X1 [KO:K07207]
101363732  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101384799  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101363844  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101373648  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
101366130  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
101381996  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
101365998  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101377322  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
101379935  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
101379849  ACSL1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
101384465  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X2 [KO:K01897] [EC:6.2.1.3]
101370699  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
101364122  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
101369334  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101367772  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
101372668  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101378518  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101368628  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101362780  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101373411  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
101376384  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101378216  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
101376526  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
101379479  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101372239  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
101380104  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
101363344  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
101385824  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
101365928  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101369899  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
101376415  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105758207  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
101371724  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101382387  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101377310  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
101364725  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101364889  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
101363335  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101377235  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
101380078  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
101378881  NDUFA7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101368566  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101376420  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101386581  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101382523  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101365566  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101370700  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
101362452  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101371446  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105757340  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101376585  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101367307  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101368539  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101367535  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X3 [KO:K03961]
101384656  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
101386359  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101366380  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
101385827  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101369135  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101368895  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101367374  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101378304  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101365603  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
101383364  NDUFAF2; mimitin, mitochondrial [KO:K18160]
101378155  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
101364323  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
101385043  NDUFAF5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 isoform X1 [KO:K18162] [EC:2.1.1.-]
101367100  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 [KO:K18163]
101364630  NDUFAF7; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 isoform X1 [KO:K18164]
101383207  uncharacterized protein C17orf89 homolog [KO:K24726]
101382073  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X3 [KO:K00234] [EC:1.3.5.1]
101380075  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101372902  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101369754  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
101369783  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101381163  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
101364292  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101374005  cytochrome b-c1 complex subunit 1, mitochondrial isoform X3 [KO:K00414]
101363987  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101372183  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101377835  cytochrome b-c1 complex subunit 7 [KO:K00417]
101386810  cytochrome b-c1 complex subunit 8 isoform X1 [KO:K00418]
101377101  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
101371164  cytochrome b-c1 complex subunit 10 [KO:K00420]
101385433  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101380146  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101379645  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101378456  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101380265  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101370880  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101368213  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101378760  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101386797  cytochrome c oxidase subunit 6B1 [KO:K02267]
101383067  cytochrome c oxidase subunit 6B1 [KO:K02267]
101374995  cytochrome c oxidase subunit 6B2 [KO:K02267]
101367693  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101381368  cytochrome c oxidase subunit 6C [KO:K02268]
101363251  cytochrome c oxidase subunit 6C [KO:K02268]
101380418  cytochrome c oxidase subunit 6C-like [KO:K02268]
101362231  cytochrome c oxidase subunit 6C [KO:K02268]
101384189  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101375046  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101376242  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101370311  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101383837  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101370574  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101377905  cytochrome c oxidase subunit 7B, mitochondrial isoform X1 [KO:K02271]
101371666  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
101365445  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101364208  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101382755  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101366998  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
101381439  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
101380734  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101371104  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
101384211  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
101374864  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
101384133  cytochrome c oxidase assembly protein COX11, mitochondrial isoform X1 [KO:K02258]
101384994  cytochrome c oxidase assembly protein COX14 [KO:K18181]
101386587  cytochrome c oxidase assembly protein COX15 homolog isoform X1 [KO:K02259] [EC:1.17.99.9]
101374477  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
101364805  cytochrome c oxidase copper chaperone [KO:K02260]
101362972  mitochondrial inner membrane protein COX18 isoform X2 [KO:K17797]
101363291  cytochrome c oxidase assembly protein COX19 [KO:K18183]
101383672  cytochrome c oxidase protein 20 homolog [KO:K18184]
101366747  cytochrome c oxidase protein 20 homolog [KO:K18184]
101370842  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
101382264  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
101375602  LOW QUALITY PROTEIN: cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
101375071  cytochrome c oxidase assembly factor 5 [KO:K18178]
101364421  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
101365095  cytochrome c oxidase assembly factor 7 [KO:K18180]
101379937  ATP5A1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
101371290  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101383079  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101375723  ATP5D; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
101366548  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
101383114  ATP5O; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
101376811  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101384384  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
101374909  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101363343  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
101366435  ATP5H; ATP synthase subunit d, mitochondrial isoform X2 [KO:K02138]
101369445  ATP synthase subunit d, mitochondrial-like [KO:K02138]
101376724  ATP synthase subunit d, mitochondrial-like isoform X2 [KO:K02138]
101362411  ATP5I; ATP synthase subunit e, mitochondrial [KO:K02129]
105758168  LOW QUALITY PROTEIN: ATP synthase subunit f, mitochondrial-like [KO:K02130]
105757055  ATP5J2; ATP synthase subunit f, mitochondrial isoform X1 [KO:K02130]
101380677  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
101362603  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
101385342  ATP synthase subunit f, mitochondrial-like [KO:K02130]
101368325  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
101384422  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
101370140  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
101378690  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
101370166  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
101363511  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101377785  ATP synthase subunit g, mitochondrial [KO:K02140]
101386844  ATP5L; ATP synthase subunit g, mitochondrial [KO:K02140]
101367746  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
101376507  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
101367719  SLC25A29; mitochondrial basic amino acids transporter isoform X1 [KO:K15109]
101373025  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
101378588  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
101363059  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:25578880
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
PMID:27264172
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
PMID:27693079
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
PMID:15024092
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
PMID:21317437
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
PMID:28723567
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
PMID:27794497
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
PMID:27984203
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
PMID:29052591
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
PMID:20514071
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
PMID:25390014
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
PMID:27681418
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
PMID:22302939
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
PMID:24820868
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
PMID:22020112
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
PMID:26303601
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
PMID:28955734
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
oro00020  Citrate cycle (TCA cycle)
oro00190  Oxidative phosphorylation
oro04010  MAPK signaling pathway
oro04022  cGMP-PKG signaling pathway
oro04024  cAMP signaling pathway
oro04150  mTOR signaling pathway
oro04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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