KEGG   PATHWAY: paeb03070
Entry
paeb03070                   Pathway                                
Name
Bacterial secretion system - Pseudomonas aeruginosa NCGM 1900
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
paeb03070  Bacterial secretion system
paeb03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas aeruginosa NCGM 1900 [GN:paeb]
Gene
NCGM1900_0813  ompK; putative outer membrane protein precursor [KO:K12340]
NCGM1900_5722  ompH; putative outer membrane efflux protein precursor [KO:K12340]
NCGM1900_2433  putative outer membrane protein [KO:K12340]
NCGM1900_4847  pscF; type III export protein [KO:K03221]
NCGM1900_4870  pscO; translocation protein in type III secretion [KO:K04056]
NCGM1900_4871  pscP; translocation protein in type III secretion [KO:K04057]
NCGM1900_4865  pcr3; hypothetical protein [KO:K04059]
NCGM1900_4849  pscC; Type III secretion outer membrane protein [KO:K03219]
NCGM1900_4868  popN; Type III secretion outer membrane protein [KO:K04058]
NCGM1900_4843  pscJ; pscJ type III export protein [KO:K03222]
NCGM1900_4873  pscR; type III secretion system protein [KO:K03226]
NCGM1900_4874  pscS; putative translocation protein in type III secretion [KO:K03227]
NCGM1900_4875  pscT; translocation protein in type III secretion [KO:K03228]
NCGM1900_4876  pscU; translocation protein in type III secretion [KO:K03229]
NCGM1900_4863  pcrD; type III secretory apparatus protein [KO:K03230]
NCGM1900_4869  pscN; type III secretion system ATPase [KO:K03224] [EC:7.4.2.8]
NCGM1900_4872  pscQ; type III secretion system protein [KO:K03225]
NCGM1900_4841  pscL; type III secretion system protein [KO:K03223]
NCGM1900_2084  hxcQ; putative type II secretion system protein [KO:K02453]
NCGM1900_4622  xqhA; secretion protein [KO:K02453]
NCGM1900_3194  xcpQ; general secretion pathway protein D [KO:K02453]
NCGM1900_2090  hxcP; hypothetical protein [KO:K02452]
NCGM1900_4623  hypothetical protein [KO:K02452]
NCGM1900_3195  xcpP; secretion protein [KO:K02452]
NCGM1900_2082  hxcS; type II secretion system protein [KO:K02455]
NCGM1900_3197  xcpS; general secretion pathway protein F [KO:K02455]
NCGM1900_3835  hplS; putative type II secretion system protein [KO:K02455]
NCGM1900_2088  hxcT; HxcT pseudopilin [KO:K02456]
NCGM1900_3198  xcpT; general secretion pathway protein G [KO:K02456]
NCGM1900_3836  hplT; putative type II secretion system protein [KO:K02456]
NCGM1900_3837  hplU; type II secretion system protein [KO:K02456]
NCGM1900_2091  hxcU; type II secretion system protein [KO:K02457]
NCGM1900_3199  xcpU; general secretion pathway outer membrane protein H [KO:K02457]
NCGM1900_2089  hxcV; HxcV putative pseudopilin [KO:K02458]
NCGM1900_3200  xcpV; general secretion pathway protein I [KO:K02458]
NCGM1900_3838  hplV; type II secretion system protein [KO:K02458]
NCGM1900_2092  hxcW; putative type II secretion system protein [KO:K02459]
NCGM1900_3201  xcpW; general secretion pathway protein J [KO:K02459]
NCGM1900_3839  hplW; putative type II secretion system protein [KO:K02459]
NCGM1900_2087  hxcX; putative type II secretion system protein [KO:K02460]
NCGM1900_3202  xcpX; general secretion pathway protein K [KO:K02460]
NCGM1900_2086  hxcY; type II secretion system protein [KO:K02461]
NCGM1900_3203  xcpY; general secretion pathway protein L [KO:K02461]
NCGM1900_2085  hxcZ; type II secretion system protein [KO:K02462]
NCGM1900_3204  xcpZ; general secretion pathway protein M [KO:K02462]
NCGM1900_2083  hxcR; putative type II secretion system protein [KO:K02454] [EC:7.4.2.8]
NCGM1900_3196  xcpR; general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
NCGM1900_6006  gspE; putative secretion pathway ATPase [KO:K02454] [EC:7.4.2.8]
NCGM1900_1156  secD; preprotein translocase subunit [KO:K03072]
NCGM1900_1157  secF; preprotein translocase subunit [KO:K03074]
NCGM1900_0683  secE; preprotein translocase subunit [KO:K03073]
NCGM1900_5480  secG; preprotein translocase subunit [KO:K03075]
NCGM1900_0716  secY; preprotein translocase subunit [KO:K03076]
NCGM1900_1155  yajC; preprotein translocase subunit [KO:K03210]
NCGM1900_6435  yidC; putative inner membrane protein translocase component [KO:K03217]
NCGM1900_2232  secA; preprotein translocase subunit [KO:K03070] [EC:7.4.2.8]
NCGM1900_0378  ftsY; signal recognition particle receptor [KO:K03110]
NCGM1900_5886  secB; preprotein translocase subunit [KO:K03071]
NCGM1900_1238  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
NCGM1900_5824  tatA; twin arginine translocase protein A [KO:K03116]
NCGM1900_5825  tatB; sec-independent translocase [KO:K03117]
NCGM1900_5826  tatC; sec-independent protein translocase [KO:K03118]
NCGM1900_0089  hypothetical protein [KO:K11904]
NCGM1900_4913  hypothetical protein [KO:K11904]
NCGM1900_5847  hypothetical protein [KO:K11904]
NCGM1900_6065  hypothetical protein [KO:K11904]
NCGM1900_0254  hypothetical protein [KO:K11904]
NCGM1900_4156  hypothetical protein [KO:K11904]
NCGM1900_2781  hypothetical protein [KO:K11904]
NCGM1900_5071  hypothetical protein [KO:K11904]
NCGM1900_2987  hypothetical protein [KO:K11904]
NCGM1900_3813  hypothetical protein [KO:K11904]
NCGM1900_0082  hypothetical protein [KO:K11903]
NCGM1900_4912  hcpD; secreted protein [KO:K11903]
NCGM1900_6066  hcpD; secreted protein [KO:K11903]
NCGM1900_0255  hcpD; secreted protein [KO:K11903]
NCGM1900_4163  hypothetical protein [KO:K11903]
NCGM1900_5070  hcpD; secreted protein [KO:K11903]
NCGM1900_0077  putative lipoprotein [KO:K11906]
NCGM1900_4901  putative lipoprotein [KO:K11906]
NCGM1900_0074  hypothetical protein [KO:K11891]
NCGM1900_4170  hypothetical protein [KO:K11891]
NCGM1900_4898  hypothetical protein [KO:K11891]
NCGM1900_0075  hypothetical protein [KO:K11892]
NCGM1900_4169  hypothetical protein [KO:K11892]
NCGM1900_4899  hypothetical protein [KO:K11892]
NCGM1900_0087  clpB; putative ClpA/B-type chaperone [KO:K11907]
NCGM1900_4905  putative ClpA/B-type protease [KO:K11907]
NCGM1900_4159  putative ClpA/B-type protease [KO:K11907]
NCGM1900_0071  ppkA; serine/threonine protein kinase [KO:K11912] [EC:2.7.11.1]
NCGM1900_0078  hypothetical protein [KO:K11913]
NCGM1900_0072  putative phosphoprotein phosphatase [KO:K11915] [EC:3.1.3.16]
NCGM1900_4897  stp1; serine/threonine phosphoprotein phosphatase [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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