KEGG   PATHWAY: pbor00260
Entry
pbor00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paludisphaera borealis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pbor00260  Glycine, serine and threonine metabolism
pbor00260

Module
pbor_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pbor00260]
pbor_M00621  Glycine cleavage system [PATH:pbor00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paludisphaera borealis [GN:pbor]
Gene
BSF38_03091  Aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSF38_04755  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSF38_00878  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BSF38_01583  thrC_2; Threonine synthase [KO:K01733] [EC:4.2.3.1]
BSF38_02544  thrC_3; Threonine synthase [KO:K01733] [EC:4.2.3.1]
BSF38_01397  thrC_1; Threonine synthase [KO:K01733] [EC:4.2.3.1]
BSF38_04362  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BSF38_01036  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSF38_00861  hprA_1; Glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BSF38_04965  garK; Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
BSF38_10033  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BSF38_04183  pspA_2; Phosphoserine phosphatase 1 [KO:K15634] [EC:5.4.2.11]
BSF38_00879  hypothetical protein [KO:K15635] [EC:5.4.2.12]
BSF38_00051  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSF38_04668  Hydroxypyruvate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSF38_05257  Putative pyridoxal phosphate-dependent acyltransferase [KO:K00639] [EC:2.3.1.29]
BSF38_02596  puo; Putrescine oxidase [KO:K00274] [EC:1.4.3.4]
BSF38_05460  maoII_2; Copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
BSF38_03571  maoII_1; Copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
BSF38_01785  gcvPA; putative glycine dehydrogenase (decarboxylating) subunit 1 [KO:K00282] [EC:1.4.4.2]
BSF38_01786  gcvPB; putative glycine dehydrogenase (decarboxylating) subunit 2 [KO:K00283] [EC:1.4.4.2]
BSF38_01783  gcvT_1; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
BSF38_05552  lpd3_2; Dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
BSF38_04416  lpd3_1; Dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
BSF38_01784  gcvH; Glycine cleavage system H protein [KO:K02437]
BSF38_02375  soxA; Monomeric sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
BSF38_05618  cbs; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
BSF38_05619  metC; Cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
BSF38_05025  mccB; Cystathionine gamma-lyase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BSF38_03299  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
BSF38_02818  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
BSF38_02634  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BSF38_02635  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BSF38_00443  doeB; N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase [KO:K15784] [EC:3.5.1.125]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pbor00010  Glycolysis / Gluconeogenesis
pbor00020  Citrate cycle (TCA cycle)
pbor00230  Purine metabolism
pbor00250  Alanine, aspartate and glutamate metabolism
pbor00270  Cysteine and methionine metabolism
pbor00290  Valine, leucine and isoleucine biosynthesis
pbor00300  Lysine biosynthesis
pbor00330  Arginine and proline metabolism
pbor00460  Cyanoamino acid metabolism
pbor00470  D-Amino acid metabolism
pbor00564  Glycerophospholipid metabolism
pbor00600  Sphingolipid metabolism
pbor00620  Pyruvate metabolism
pbor00630  Glyoxylate and dicarboxylate metabolism
pbor00640  Propanoate metabolism
pbor00680  Methane metabolism
pbor00860  Porphyrin metabolism
pbor00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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