KEGG   PATHWAY: pcon00260
Entry
pcon00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paracoccus contaminans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pcon00260  Glycine, serine and threonine metabolism
pcon00260

Module
pcon_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pcon00260]
pcon_M00621  Glycine cleavage system [PATH:pcon00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paracoccus contaminans [GN:pcon]
Gene
B0A89_03500  aspartate kinase [KO:K00928] [EC:2.7.2.4]
B0A89_05970  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
B0A89_13710  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
B0A89_09085  threonine synthase [KO:K01733] [EC:4.2.3.1]
B0A89_13380  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
B0A89_08565  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B0A89_03670  septum site-determining protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
B0A89_00910  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
B0A89_07290  glycerate kinase [KO:K11529] [EC:2.7.1.165]
B0A89_08340  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
B0A89_08200  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B0A89_08205  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
B0A89_09305  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
B0A89_01865  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
B0A89_09825  flavin monoamine oxidase [KO:K00274] [EC:1.4.3.4]
B0A89_04790  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
B0A89_04800  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
B0A89_08670  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
B0A89_00625  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
B0A89_04795  glycine cleavage system protein H [KO:K02437]
B0A89_05560  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
B0A89_05565  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
B0A89_06605  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
B0A89_06590  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
B0A89_06610  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
B0A89_06600  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
B0A89_08405  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
B0A89_03530  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B0A89_12250  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
B0A89_00515  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pcon00010  Glycolysis / Gluconeogenesis
pcon00020  Citrate cycle (TCA cycle)
pcon00230  Purine metabolism
pcon00250  Alanine, aspartate and glutamate metabolism
pcon00270  Cysteine and methionine metabolism
pcon00290  Valine, leucine and isoleucine biosynthesis
pcon00300  Lysine biosynthesis
pcon00330  Arginine and proline metabolism
pcon00470  D-Amino acid metabolism
pcon00564  Glycerophospholipid metabolism
pcon00620  Pyruvate metabolism
pcon00630  Glyoxylate and dicarboxylate metabolism
pcon00640  Propanoate metabolism
pcon00680  Methane metabolism
pcon00860  Porphyrin metabolism
pcon00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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