KEGG   PATHWAY: pdic05207
Entry
pdic05207                   Pathway                                
Name
Chemical carcinogenesis - receptor activation - Phyllostomus discolor (pale spear-nosed bat)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
pdic05207  Chemical carcinogenesis - receptor activation
pdic05207

Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114488626  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
114499574  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
114515025  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
114506489  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114501905  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
114508470  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
114506109  E2F1; transcription factor E2F1 [KO:K17454]
114503458  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
114490782  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
114504538  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
114502978  CDC6; cell division control protein 6 homolog isoform X2 [KO:K02213]
114501673  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
114496018  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
114502756  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
114512155  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
114500683  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114506756  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 isoform X1 [KO:K04806]
114488948  CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
114488506  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
114488641  CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
114512949  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
114501473  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
114505705  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114512262  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
114494895  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X10 [KO:K04849]
114502598  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
114497407  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114490993  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114501452  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114496100  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114502559  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
114501063  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114510957  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114512350  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114492688  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114496034  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114492465  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
114499888  RELA; transcription factor p65 [KO:K04735]
114499504  HRAS; GTPase HRas isoform X2 [KO:K02833]
114512682  KRAS; GTPase KRas isoform X1 [KO:K07827]
114489186  NRAS; GTPase NRas [KO:K07828]
114491735  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
114503388  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114510156  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114496946  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114493153  FOS; proto-oncogene c-Fos [KO:K04379]
114496428  JUN; transcription factor AP-1 [KO:K04448]
114514698  MYC; myc proto-oncogene protein [KO:K04377]
114507071  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114502829  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114494685  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
114511158  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114494974  VEGFA; vascular endothelial growth factor A [KO:K05448]
114502553  FGF2; fibroblast growth factor 2 [KO:K18497]
114495957  ADRB1; beta-1 adrenergic receptor [KO:K04141]
114510124  ADRB2; beta-2 adrenergic receptor [KO:K04142]
114508710  ADRB3; beta-3 adrenergic receptor [KO:K04143]
114506244  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
114507035  neuroendocrine secretory protein 55-like [KO:K04632]
114490247  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
114508056  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
114500049  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
114492860  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
114490544  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
114512738  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
114488191  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
114514654  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114503776  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
114505902  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
114502442  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114496184  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114495167  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114495679  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114512782  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114509629  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X3 [KO:K09048]
114488748  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
114503508  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
114499717  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
114508155  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
114508223  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
114495166  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
114488966  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
114507572  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
114501423  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
114499526  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
114492783  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 isoform X1 [KO:K04810]
114496354  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
114490089  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
114505116  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114505441  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114494656  ESR1; estrogen receptor [KO:K08550]
114492760  ESR2; estrogen receptor beta [KO:K08551]
114513324  VDR; vitamin D3 receptor [KO:K08539]
114494075  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114507607  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114503433  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
114499241  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114493440  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
114508926  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
114502684  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114499422  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
114497357  PAQR7; membrane progestin receptor alpha isoform X2 [KO:K25039]
114494271  PAQR8; membrane progestin receptor beta [KO:K25040]
114492622  PAQR5; membrane progestin receptor gamma isoform X1 [KO:K25041]
114499975  PGR; progesterone receptor [KO:K08556]
114508772  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
114503056  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
114502991  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
114491118  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
114508498  KLF5; Krueppel-like factor 5 [KO:K09206]
114506600  KLF4; Krueppel-like factor 4 isoform X1 [KO:K17846]
114512643  WNT1; proto-oncogene Wnt-1 [KO:K03209]
114488857  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
114506205  JAG1; LOW QUALITY PROTEIN: protein jagged-1 [KO:K06052]
114505275  AR; androgen receptor [KO:K08557]
114492590  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114509809  FGF18; fibroblast growth factor 18 [KO:K04358]
114496691  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
114503602  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
114504014  FGF17; fibroblast growth factor 17 [KO:K04358]
114512610  FGF6; fibroblast growth factor 6 [KO:K04358]
114491712  FGF7; fibroblast growth factor 7 [KO:K04358]
114499168  FGF3; fibroblast growth factor 3 [KO:K04358]
114505270  FGF16; fibroblast growth factor 16 [KO:K04358]
114514054  FGF9; fibroblast growth factor 9 [KO:K04358]
114493120  FGF5; fibroblast growth factor 5 [KO:K04358]
114500857  FGF4; fibroblast growth factor 4 [KO:K04358]
114501717  FGF10; fibroblast growth factor 10 [KO:K04358]
114508944  FGF20; fibroblast growth factor 20 [KO:K04358]
114490074  DLL1; delta-like protein 1 [KO:K06051]
114493174  DLL4; delta-like protein 4 [KO:K06051]
114511339  DLL3; delta-like protein 3 [KO:K06051]
114512784  PTGES3; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
114499225  AH receptor-interacting protein isoform X1 [KO:K17767]
114515221  AIPL1; aryl-hydrocarbon-interacting protein-like 1 isoform X1 [KO:K17767]
114507699  AHR; aryl hydrocarbon receptor [KO:K09093]
114491678  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
114494561  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
114512720  HSP90B1; endoplasmin [KO:K09487]
114491054  KPNA1; importin subunit alpha-5 [KO:K23940]
114503072  KPNA2; importin subunit alpha-1 [KO:K15043]
114490997  KPNA4; importin subunit alpha-3 isoform X2 [KO:K23583]
114508422  KPNA3; LOW QUALITY PROTEIN: importin subunit alpha-4 [KO:K23583]
114496019  KPNA6; importin subunit alpha-7 [KO:K15042]
114494381  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
114502715  KPNB1; importin subunit beta-1 [KO:K14293]
114488743  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
114492343  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
114500131  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
114512342  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
114503007  EPHX2; bifunctional epoxide hydrolase 2 isoform X2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
114503326  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
114497589  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
114509465  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
114509683  glutathione S-transferase theta-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
114509790  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
114510064  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
114488950  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
114489165  GSTM4; LOW QUALITY PROTEIN: glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
114489162  GSTM3; LOW QUALITY PROTEIN: glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
114496727  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
114497484  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
114511854  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
114504295  MGST2; microsomal glutathione S-transferase 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
114513352  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
114494580  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
114494581  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
114494628  glutathione S-transferase A2-like isoform X3 [KO:K00799] [EC:2.5.1.18]
114491865  UGT2A3; UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
118499650  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
114491764  UDP-glucuronosyltransferase 2A3 isoform X1 [KO:K00699] [EC:2.4.1.17]
114492295  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
114492296  UDP-glucuronosyltransferase 2B31-like isoform X2 [KO:K00699] [EC:2.4.1.17]
114492463  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
114494130  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
114494131  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
114494134  UDP-glucuronosyltransferase 1A10-like [KO:K00699] [EC:2.4.1.17]
114494135  UDP-glucuronosyltransferase 1A10-like [KO:K00699] [EC:2.4.1.17]
114494355  UDP-glucuronosyltransferase 1-6-like isoform X3 [KO:K00699] [EC:2.4.1.17]
114511724  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
114507768  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
114495619  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
114511852  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
114492349  cytochrome P450 3A12 isoform X1 [KO:K07424] [EC:1.14.14.1]
114492360  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
114492026  LOW QUALITY PROTEIN: cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
114513128  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
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Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
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Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
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Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
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Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
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Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
  Journal
Trends Pharmacol Sci 29:151-8 (2008)
DOI:10.1016/j.tips.2007.12.006
Reference
PMID:24830349
  Authors
Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
  Journal
Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:28664511
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
PMID:22330135
  Authors
Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ
  Title
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
  Journal
Oncogene 32:151-9 (2013)
DOI:10.1038/onc.2012.39
Reference
PMID:20106947
  Authors
Chen RJ, Ho YS, Guo HR, Wang YJ
  Title
Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
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Related
pathway
pdic00980  Metabolism of xenobiotics by cytochrome P450
pdic03320  PPAR signaling pathway
pdic04010  MAPK signaling pathway
pdic04024  cAMP signaling pathway
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04370  VEGF signaling pathway
pdic04915  Estrogen signaling pathway
pdic05204  Chemical carcinogenesis - DNA adducts
pdic05206  MicroRNAs in cancer
pdic05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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