Entry
Name
Lipoic acid metabolism - Pseudoalteromonas translucida TAC125
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Ortholog table
Module
pha_M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:pha00785 ]
Other DBs
Organism
Pseudoalteromonas translucida TAC125 [GN:
pha ]
Gene
PSHAa1019 lipA; Lipoyl synthase (Lipoic acid synthase) (Lipoate synthase) (Lipoyl-acyl-carrier protein synthase) (Sulfur insertion protein lipA) (Lip-syn) [KO:K03644 ] [EC:2.8.1.8 ]
PSHAa0393 lpd; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes [KO:K00382 ] [EC:1.8.1.4 ]
PSHAa1647 sucA; 2-oxoglutarate decarboxylase, component of the 2-oxoglutarate dehydrogenase complex, thiamin-binding [KO:K00164 ] [EC:1.2.4.2 ]
PSHAa1646 sucB; dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex [KO:K00658 ] [EC:2.3.1.61 ]
PSHAa1632 BckdhA; 2-oxoisovalerate dehydrogenase alpha subunit (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha) (BCKDE1A) [KO:K00166 ] [EC:1.2.4.4 ]
PSHAa1631 bkdA2; 2-oxoisovalerate dehydrogenase beta subunit (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta) [KO:K00167 ] [EC:1.2.4.4 ]
PSHAa1630 dbT; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit) [KO:K09699 ] [EC:2.3.1.168 ]
PSHAa2473 gcvP; glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent [KO:K00281 ] [EC:1.4.4.2 ]
PSHAa2475 gcvT; glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent [KO:K00605 ] [EC:2.1.2.10 ]
PSHAa2474 gcvH; glycine cleavage system H protein, carrier of aminomethyl moiety via covalently bound lipoyl cofactor [KO:K02437 ]
Compound
C00141 3-Methyl-2-oxobutanoic acid
C00143 5,10-Methylenetetrahydrofolate
C00233 4-Methyl-2-oxopentanoate
C00671 (S)-3-Methyl-2-oxopentanoic acid
C01242 [Protein]-S8-aminomethyldihydrolipoyllysine
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C06157 [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C15974 3-Methyl-1-hydroxybutyl-ThPP
C15975 [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976 2-Methyl-1-hydroxypropyl-ThPP
C15977 [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978 2-Methyl-1-hydroxybutyl-ThPP
C15979 [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980 (S)-2-Methylbutanoyl-CoA
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
C22159 [Glycine cleavage system H]-N6-octanoyl-L-lysine
C22160 [Lipoyl-carrier protein E2]-N6-octanoyl-L-lysine
C22667 4-Carboxy-1-hydroxybutyryl-ThPP
Reference
Authors
Gunther S, McMillan PJ, Wallace LJ, Muller S.
Title
Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways.
Journal
Reference
Authors
Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y.
Title
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.
Journal
Reference
Authors
Yasuno R, Wada H.
Title
Biosynthesis of lipoic acid in Arabidopsis: cloning and characterization of the cDNA for lipoic acid synthase.
Journal
Reference
Authors
Gueguen V, Macherel D, Jaquinod M, Douce R, Bourguignon J.
Title
Fatty acid and lipoic acid biosynthesis in higher plant mitochondria.
Journal
Reference
Authors
Wada M, Yasuno R, Jordan SW, Cronan JE Jr, Wada H.
Title
Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase.
Journal
Reference
Authors
Morris TW, Reed KE, Cronan JE Jr.
Title
Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product.
Journal
J Biol Chem 269:16091-100 (1994)
Reference
Authors
Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE.
Title
Assembly of the covalent linkage between lipoic acid and its cognate enzymes.
Journal
Reference
Authors
Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ.
Title
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.
Journal
Reference
Authors
Solmonson A, DeBerardinis RJ
Title
Lipoic acid metabolism and mitochondrial redox regulation.
Journal
Reference
Authors
Cronan JE
Title
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.
Journal
Reference
Authors
Mayr JA, Feichtinger RG, Tort F, Ribes A, Sperl W
Title
Lipoic acid biosynthesis defects.
Journal
Reference
Authors
Cao X, Zhu L, Song X, Hu Z, Cronan JE
Title
Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes.
Journal
Reference
Authors
Soreze Y, Boutron A, Habarou F, Barnerias C, Nonnenmacher L, Delpech H, Mamoune A, Chretien D, Hubert L, Bole-Feysot C, Nitschke P, Correia I, Sardet C, Boddaert N, Hamel Y, Delahodde A, Ottolenghi C, de Lonlay P
Title
Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.
Journal
Reference
Authors
Habarou F, Hamel Y, Haack TB, Feichtinger RG, Lebigot E, Marquardt I, Busiah K, Laroche C, Madrange M, Grisel C, Pontoizeau C, Eisermann M, Boutron A, Chretien D, Chadefaux-Vekemans B, Barouki R, Bole-Feysot C, Nitschke P, Goudin N, Boddaert N, Nemazanyy I, Delahodde A, Kolker S, Rodenburg RJ, Korenke GC, Meitinger T, Strom TM, Prokisch H, Rotig A, Ottolenghi C, Mayr JA, de Lonlay P
Title
Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy.
Journal
Reference
Authors
Spalding MD, Prigge ST
Title
Lipoic acid metabolism in microbial pathogens.
Journal
Reference
Authors
Guerra AJ, Afanador GA, Prigge ST
Title
Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.
Journal
Reference
Authors
Afanador GA, Matthews KA, Bartee D, Gisselberg JE, Walters MS, Freel Meyers CL, Prigge ST
Title
Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.
Journal
Reference
Authors
Afanador GA, Guerra AJ, Swift RP, Rodriguez RE, Bartee D, Matthews KA, Schon A, Freire E, Freel Meyers CL, Prigge ST
Title
A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.
Journal
Reference
Authors
Storm J, Muller S
Title
Lipoic acid metabolism of Plasmodium--a suitable drug target.
Journal
Reference
Authors
Gunther S, Wallace L, Patzewitz EM, McMillan PJ, Storm J, Wrenger C, Bissett R, Smith TK, Muller S
Title
Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.
Journal
Reference
Authors
Wrenger C, Muller S
Title
The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways.
Journal
Reference
Authors
Martin N, Christensen QH, Mansilla MC, Cronan JE, de Mendoza D
Title
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.
Journal
Reference
Authors
Christensen QH, Martin N, Mansilla MC, de Mendoza D, Cronan JE
Title
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.
Journal
Related pathway
pha00260 Glycine, serine and threonine metabolism
pha00280 Valine, leucine and isoleucine degradation
KO pathway
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