KEGG   PATHWAY: pha00785
Entry
pha00785                    Pathway                                
Name
Lipoic acid metabolism - Pseudoalteromonas translucida TAC125
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
pha00785  Lipoic acid metabolism
pha00785

Module
pha_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:pha00785]
pha_M00621  Glycine cleavage system [PATH:pha00785]
pha_M00881  Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:pha00785]
Other DBs
GO: 0009106
Organism
Pseudoalteromonas translucida TAC125 [GN:pha]
Gene
PSHAa1020  lipB; Lipoate-protein ligase B [KO:K03801] [EC:2.3.1.181]
PSHAa1019  lipA; Lipoyl synthase (Lipoic acid synthase) (Lipoate synthase) (Lipoyl-acyl-carrier protein synthase) (Sulfur insertion protein lipA) (Lip-syn) [KO:K03644] [EC:2.8.1.8]
PSHAa0758  putative pyridine nucleotide-disulfide oxidoreductase, class I [KO:K00382] [EC:1.8.1.4]
PSHAa0393  lpd; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes [KO:K00382] [EC:1.8.1.4]
PSHAa0391  aceE; pyruvate dehydrogenase, decarboxylase subunit, thiamin-binding [KO:K00163] [EC:1.2.4.1]
PSHAa0392  aceF; pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit [KO:K00627] [EC:2.3.1.12]
PSHAa1647  sucA; 2-oxoglutarate decarboxylase, component of the 2-oxoglutarate dehydrogenase complex, thiamin-binding [KO:K00164] [EC:1.2.4.2]
PSHAa1646  sucB; dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex [KO:K00658] [EC:2.3.1.61]
PSHAa1632  BckdhA; 2-oxoisovalerate dehydrogenase alpha subunit (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha) (BCKDE1A) [KO:K00166] [EC:1.2.4.4]
PSHAa1631  bkdA2; 2-oxoisovalerate dehydrogenase beta subunit (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta) [KO:K00167] [EC:1.2.4.4]
PSHAa1630  dbT; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit) [KO:K09699] [EC:2.3.1.168]
PSHAa2473  gcvP; glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent [KO:K00281] [EC:1.4.4.2]
PSHAa2475  gcvT; glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent [KO:K00605] [EC:2.1.2.10]
PSHAa2474  gcvH; glycine cleavage system H protein, carrier of aminomethyl moiety via covalently bound lipoyl cofactor [KO:K02437]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00141  3-Methyl-2-oxobutanoic acid
C00143  5,10-Methylenetetrahydrofolate
C00233  4-Methyl-2-oxopentanoate
C00322  2-Oxoadipate
C00527  Glutaryl-CoA
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01944  Octanoyl-CoA
C02051  Lipoylprotein
C02147  Dihydrolipoate
C02939  3-Methylbutanoyl-CoA
C02972  Dihydrolipoylprotein
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C05752  Octanoyl-[acp]
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C06423  Octanoic acid
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C16238  Lipoyl-AMP
C16241  (R)-Lipoate
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
C22159  [Glycine cleavage system H]-N6-octanoyl-L-lysine
C22160  [Lipoyl-carrier protein E2]-N6-octanoyl-L-lysine
C22161  Dihydrolipoyl-AMP
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
  Authors
Gunther S, McMillan PJ, Wallace LJ, Muller S.
  Title
Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways.
  Journal
Biochem Soc Trans 33:977-80 (2005)
DOI:10.1042/BST20050977
Reference
  Authors
Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y.
  Title
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.
  Journal
J Biol Chem 276:28819-23 (2001)
DOI:10.1074/jbc.M101748200
Reference
PMID:9808738
  Authors
Yasuno R, Wada H.
  Title
Biosynthesis of lipoic acid in Arabidopsis: cloning and characterization of the cDNA for lipoic acid synthase.
  Journal
Plant Physiol 118:935-43 (1998)
DOI:10.1104/pp.118.3.935
Reference
  Authors
Gueguen V, Macherel D, Jaquinod M, Douce R, Bourguignon J.
  Title
Fatty acid and lipoic acid biosynthesis in higher plant mitochondria.
  Journal
J Biol Chem 275:5016-25 (2000)
DOI:10.1074/jbc.275.7.5016
Reference
  Authors
Wada M, Yasuno R, Jordan SW, Cronan JE Jr, Wada H.
  Title
Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase.
  Journal
Plant Cell Physiol 42:650-6 (2001)
DOI:10.1093/pcp/pce081
Reference
PMID:8206909
  Authors
Morris TW, Reed KE, Cronan JE Jr.
  Title
Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product.
  Journal
J Biol Chem 269:16091-100 (1994)
Reference
  Authors
Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE.
  Title
Assembly of the covalent linkage between lipoic acid and its cognate enzymes.
  Journal
Chem Biol 10:1293-302 (2003)
DOI:10.1016/j.chembiol.2003.11.016
Reference
  Authors
Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ.
  Title
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.
  Journal
Protein Expr Purif 39:269-82 (2005)
DOI:10.1016/j.pep.2004.10.021
Reference
  Authors
Solmonson A, DeBerardinis RJ
  Title
Lipoic acid metabolism and mitochondrial redox regulation.
  Journal
J Biol Chem 293:7522-7530 (2018)
DOI:10.1074/jbc.TM117.000259
Reference
  Authors
Cronan JE
  Title
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.
  Journal
Microbiol Mol Biol Rev 80:429-50 (2016)
DOI:10.1128/MMBR.00073-15
Reference
  Authors
Mayr JA, Feichtinger RG, Tort F, Ribes A, Sperl W
  Title
Lipoic acid biosynthesis defects.
  Journal
J Inherit Metab Dis 37:553-63 (2014)
DOI:10.1007/s10545-014-9705-8
Reference
  Authors
Cao X, Zhu L, Song X, Hu Z, Cronan JE
  Title
Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes.
  Journal
Proc Natl Acad Sci U S A 115:E7063-E7072 (2018)
DOI:10.1073/pnas.1805862115
Reference
  Authors
Soreze Y, Boutron A, Habarou F, Barnerias C, Nonnenmacher L, Delpech H, Mamoune A, Chretien D, Hubert L, Bole-Feysot C, Nitschke P, Correia I, Sardet C, Boddaert N, Hamel Y, Delahodde A, Ottolenghi C, de Lonlay P
  Title
Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.
  Journal
Orphanet J Rare Dis 8:192 (2013)
DOI:10.1186/1750-1172-8-192
Reference
  Authors
Habarou F, Hamel Y, Haack TB, Feichtinger RG, Lebigot E, Marquardt I, Busiah K, Laroche C, Madrange M, Grisel C, Pontoizeau C, Eisermann M, Boutron A, Chretien D, Chadefaux-Vekemans B, Barouki R, Bole-Feysot C, Nitschke P, Goudin N, Boddaert N, Nemazanyy I, Delahodde A, Kolker S, Rodenburg RJ, Korenke GC, Meitinger T, Strom TM, Prokisch H, Rotig A, Ottolenghi C, Mayr JA, de Lonlay P
  Title
Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy.
  Journal
Am J Hum Genet 101:283-290 (2017)
DOI:10.1016/j.ajhg.2017.07.001
Reference
  Authors
Spalding MD, Prigge ST
  Title
Lipoic acid metabolism in microbial pathogens.
  Journal
Microbiol Mol Biol Rev 74:200-28 (2010)
DOI:10.1128/MMBR.00008-10
Reference
  Authors
Guerra AJ, Afanador GA, Prigge ST
  Title
Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.
  Journal
Proteins 85:1777-1783 (2017)
DOI:10.1002/prot.25324
Reference
  Authors
Afanador GA, Matthews KA, Bartee D, Gisselberg JE, Walters MS, Freel Meyers CL, Prigge ST
  Title
Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.
  Journal
Mol Microbiol 94:156-71 (2014)
DOI:10.1111/mmi.12753
Reference
  Authors
Afanador GA, Guerra AJ, Swift RP, Rodriguez RE, Bartee D, Matthews KA, Schon A, Freire E, Freel Meyers CL, Prigge ST
  Title
A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.
  Journal
Mol Microbiol 106:439-451 (2017)
DOI:10.1111/mmi.13776
Reference
  Authors
Storm J, Muller S
  Title
Lipoic acid metabolism of Plasmodium--a suitable drug target.
  Journal
Curr Pharm Des 18:3480-9 (2012)
DOI:10.2174/138161212801327266
Reference
  Authors
Gunther S, Wallace L, Patzewitz EM, McMillan PJ, Storm J, Wrenger C, Bissett R, Smith TK, Muller S
  Title
Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.
  Journal
PLoS Pathog 3:e189 (2007)
DOI:10.1371/journal.ppat.0030189
Reference
  Authors
Wrenger C, Muller S
  Title
The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways.
  Journal
Mol Microbiol 53:103-13 (2004)
DOI:10.1111/j.1365-2958.2004.04112.x
Reference
  Authors
Martin N, Christensen QH, Mansilla MC, Cronan JE, de Mendoza D
  Title
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.
  Journal
Mol Microbiol 80:335-49 (2011)
DOI:10.1111/j.1365-2958.2011.07597.x
Reference
  Authors
Christensen QH, Martin N, Mansilla MC, de Mendoza D, Cronan JE
  Title
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.
  Journal
Mol Microbiol 80:350-63 (2011)
DOI:10.1111/j.1365-2958.2011.07598.x
Related
pathway
pha00020  Citrate cycle (TCA cycle)
pha00061  Fatty acid biosynthesis
pha00260  Glycine, serine and threonine metabolism
pha00280  Valine, leucine and isoleucine degradation
pha00310  Lysine degradation
pha00620  Pyruvate metabolism
KO pathway
ko00785   
LinkDB

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