KEGG   PATHWAY: phai00480
Entry
phai00480                   Pathway                                
Name
Glutathione metabolism - Panicum hallii (Hall's panicgrass)
Class
Metabolism; Metabolism of other amino acids
Pathway map
phai00480  Glutathione metabolism
phai00480

Module
phai_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:phai00480]
Other DBs
GO: 0006749
Organism
Panicum hallii (Hall's panicgrass) [GN:phai]
Gene
112895703  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
112901603  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
112899877  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
112877649  gamma-glutamylcyclotransferase 2-2 [KO:K22596] [EC:4.3.2.9]
112873629  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
112886149  glutamate--cysteine ligase A, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
112894044  glutamate--cysteine ligase A, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
112884660  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
112903410  glutathione synthetase, chloroplastic-like isoform X1 [KO:K21456] [EC:6.3.2.3]
112892591  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
112898792  leucine aminopeptidase 2, chloroplastic-like isoform X1 [KO:K01255] [EC:3.4.11.1]
112887309  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
112896714  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
112882105  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
112894210  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
112894360  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
112882417  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
112882617  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
112895539  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112895540  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112872664  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
112872908  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112873177  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
112873194  uncharacterized protein LOC112873194 [KO:K00799] [EC:2.5.1.18]
112873197  uncharacterized protein LOC112873197 [KO:K00799] [EC:2.5.1.18]
112873200  uncharacterized protein LOC112873200 [KO:K00799] [EC:2.5.1.18]
112873204  uncharacterized protein LOC112873204 [KO:K00799] [EC:2.5.1.18]
112873689  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
112885864  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
112874949  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
112887085  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
112875071  protein IN2-1 homolog B isoform X1 [KO:K00799] [EC:2.5.1.18]
112875345  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
112875408  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112875410  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
112875736  protein IN2-1 [KO:K00799] [EC:2.5.1.18]
112875835  glutathione S-transferase F8, chloroplastic-like [KO:K00799] [EC:2.5.1.18]
112875836  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
112875874  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112875925  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
112876238  protein IN2-1 homolog B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112876282  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
112889377  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
112876299  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
112876550  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
112876584  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
112877030  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112877031  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112889629  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112877637  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112877898  probable glutathione S-transferase BZ2 [KO:K00799] [EC:2.5.1.18]
112879726  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
112892223  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112892224  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
112892225  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112892226  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112892228  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
112892229  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112893030  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
112893355  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112881377  protein IN2-1 homolog A-like [KO:K00799] [EC:2.5.1.18]
112893615  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
112893749  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
112893750  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
112893751  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
112873203  uncharacterized protein LOC112873203 [KO:K00799] [EC:2.5.1.18]
112887710  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
112890073  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
112873473  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
112875419  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
112889642  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
112884321  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
112900292  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
112893385  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
112894186  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
112889205  6-phosphogluconate dehydrogenase, decarboxylating 1-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
112902525  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
112872641  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
112899472  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
112899672  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
112874514  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
112892286  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
112875158  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
112901407  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
112901460  probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial [KO:K00432] [EC:1.11.1.9]
112889338  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
112876458  probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial [KO:K00432] [EC:1.11.1.9]
112903154  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
112878861  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
112881962  1-Cys peroxiredoxin PER1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
112882111  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
112882782  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
112883037  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
112889392  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
112892329  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
112896534  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
112896981  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
112884946  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
112873832  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
112899872  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
112901091  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
112890455  probable L-ascorbate peroxidase 8, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
112880254  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
112895156  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
112890968  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
112900076  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
112888488  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
phai00220  Arginine biosynthesis
phai00250  Alanine, aspartate and glutamate metabolism
phai00270  Cysteine and methionine metabolism
phai00430  Taurine and hypotaurine metabolism
phai00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

DBGET integrated database retrieval system