KEGG   PATHWAY: pin02010
Entry
pin02010                    Pathway                                
Name
ABC transporters - Psychromonas ingrahamii
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
pin02010  ABC transporters
pin02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Psychromonas ingrahamii [GN:pin]
Gene
Ping_0047  taurine ABC transporter, periplasmic binding protein [KO:K15551]
Ping_0049  ABC taurine transporter, binding protein inner membrane component [KO:K15552]
Ping_0048  ABC transporter for nitrate/sulfonate/bicarbonate ATP-binding protein [KO:K10831] [EC:7.6.2.7]
Ping_2375  ABC transporter substrate-binding protein [KO:K15598]
Ping_2376  ABC transporter substrate binding inner membrane protein [KO:K15599]
Ping_2377  ABC transporter ATP-binding protein [KO:K15600]
Ping_2166  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
Ping_2165  molybdate ABC transporter, inner membrane subunit [KO:K02018]
Ping_2164  molybdate ABC transporter, ATPase subunit [KO:K02017] [EC:7.3.2.5]
Ping_0976  modF; ABC transporter for molybdenum ATP-binding protein ModF [KO:K05776]
Ping_2746  ABC transporter periplasmic substrate-binding protein [KO:K02012]
Ping_3007  ABC iron(III) transporter periplasmic binding protein [KO:K02012]
Ping_3006  iron(III) ABC transporter, inner membrane binding component [KO:K02011]
Ping_2744  ABC transporter binding protein inner membrane protein [KO:K02011]
Ping_2745  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
Ping_3005  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
Ping_0385  thiamine ABC transporter, periplasmic binding protein [KO:K02064]
Ping_0386  thiamine ABC transporter, inner membrane subunit [KO:K02063]
Ping_0387  ABC transporter for thiamin ATP-binding protein [KO:K02062] [EC:7.6.2.15]
Ping_1238  Spermidine/putrescine-binding periplasmic protein-like protein [KO:K11069]
Ping_2073  Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002]
Ping_0614  Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002]
Ping_3427  Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002]
Ping_2074  ABC transporter substrate binding inner membrane protein [KO:K02001]
Ping_3425  ABC transporter substrate binding inner membrane protein [KO:K02001]
Ping_0615  glycine betaine ABC transporter, binding protein inner membrane component [KO:K02001]
Ping_2075  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K02000] [EC:7.6.2.9]
Ping_3426  ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
Ping_0616  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K02000] [EC:7.6.2.9]
Ping_2011  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10111] [EC:7.5.2.-]
Ping_2512  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10111] [EC:7.5.2.-]
Ping_1959  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112] [EC:7.5.2.-]
Ping_2910  trehalose-binding protein / maltose-binding protein / sucrose-binding protein [KO:K10232]
Ping_2911  sucrose ABC transporter membrane protein / trehalose ABC transporter membrane protein / maltose ABC transporter membrane protein [KO:K10233]
Ping_2912  trehalose ABC transporter membrane protein / sucrose ABC transporter membrane protein / maltose ABC transporter membrane protein [KO:K10234]
Ping_2913  sucrose ABC transporter ATP-binding protein / trehalose ABC transporter ATP-binding protein / maltose ABC transporter ATP-binding protein [KO:K10235]
Ping_2884  ABC-type transporter periplasmic protein [KO:K07323]
Ping_1679  Mammalian cell entry related domain protein [KO:K02067]
Ping_2885  Mammalian cell entry related domain protein [KO:K02067]
Ping_2886  ABC-type transporter inner membrane protein [KO:K02066]
Ping_1681  hypothetical protein DUF140 [KO:K02066]
Ping_2883  hypothetical protein [KO:K07122]
Ping_2887  ABC transporter ATP-binding protein [KO:K02065]
Ping_1680  ABC transporter ATP-binding protein [KO:K02065]
Ping_1297  nucleoside-binding protein [KO:K07335]
Ping_1299  nucleoside ABC transporter membrane protein [KO:K23535]
Ping_1300  nucleoside ABC transporter membrane protein [KO:K23536]
Ping_1298  nucleoside ABC transporter ATP-binding protein [KO:K23537]
Ping_1956  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K17315]
Ping_2284  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K17315]
Ping_1957  carbohydrate ABC transporter membrane protein 1, CUT1 family [KO:K17316]
Ping_1958  carbohydrate ABC transporter membrane protein 2, CUT1 family [KO:K17317]
Ping_1312  monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439]
Ping_1110  monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439]
Ping_0343  ribose-binding protein [KO:K10439]
Ping_2806  monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439]
Ping_2804  monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439]
Ping_2790  monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439]
Ping_0342  ribose ABC transporter membrane protein [KO:K10440]
Ping_2807  inner-membrane translocator [KO:K10440]
Ping_2789  monosaccharide ABC transporter membrane protein, CUT2 family [KO:K10440]
Ping_2788  monosaccharide ABC transporter membrane protein, CUT2 family [KO:K10440]
Ping_0341  ribose ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
Ping_2808  monosaccharide ABC transporter ATP-binding protein, CUT2 family [KO:K10441] [EC:7.5.2.7]
Ping_2787  monosaccharide ABC transporter ATP-binding protein, CUT2 family [KO:K10441] [EC:7.5.2.7]
Ping_0340  ribose transport protein RbsD [KO:K06726] [EC:5.4.99.62]
Ping_3169  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K17321]
Ping_3172  carbohydrate ABC transporter membrane protein 1, CUT1 family [KO:K17322]
Ping_3171  carbohydrate ABC transporter membrane protein 2, CUT1 family [KO:K17323]
Ping_3174  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K17324]
Ping_3173  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K17325]
Ping_2093  carbohydrate ABC transporter substrate-binding protein, CUT1 family [KO:K05813]
Ping_2094  carbohydrate ABC transporter membrane protein 1, CUT1 family [KO:K05814]
Ping_2095  carbohydrate ABC transporter membrane protein 2, CUT1 family [KO:K05815]
Ping_2096  carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K05816] [EC:7.6.2.10]
Ping_2588  phosphate ABC transporter substrate-binding protein, PhoT family [KO:K02040]
Ping_2409  phosphate ABC transporter substrate-binding protein, PhoT family [KO:K02040]
Ping_2587  phosphate ABC transporter substrate-binding protein, PhoT family [KO:K02040]
Ping_2408  phosphate ABC transporter membrane protein 1, PhoT family [KO:K02037]
Ping_2589  pstC; phosphate ABC transporter membrane protein 1, PhoT family [KO:K02037]
Ping_2407  phosphate ABC transporter membrane protein 2, PhoT family [KO:K02038]
Ping_2590  pstA; phosphate ABC transporter membrane protein 2, PhoT family [KO:K02038]
Ping_2406  phosphate ABC transporter ATP-binding protein, PhoT family [KO:K02036] [EC:7.3.2.1]
Ping_2591  phosphate ABC transporter ATP-binding protein, PhoT family [KO:K02036] [EC:7.3.2.1]
Ping_1770  ABC phosphonate transporter periplasmic phosphonate-binding protein [KO:K02044]
Ping_3695  ABC phosphonate transporter periplasmic phosphonate-binding protein [KO:K02044]
Ping_3693  ABC phosphonate transporter inner membrane protein [KO:K02042]
Ping_1768  ABC transporter complex for phosphonate inner membrane binding subunit [KO:K02042]
Ping_1769  ABC transporter ATP-binding protein, predicted for phosphonate [KO:K02041] [EC:7.3.2.2]
Ping_3694  ABC phosphonate transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
Ping_0296  amino acid ABC transporter substrate-binding protein, PAAT family [KO:K09997]
Ping_2818  amino acid ABC transporter substrate-binding protein, PAAT family [KO:K09969]
Ping_2822  amino acid ABC transporter substrate-binding protein, PAAT family [KO:K09969]
Ping_2819  amino acid ABC transporter membrane protein 1, PAAT family [KO:K09970]
Ping_2823  amino acid ABC transporter membrane protein 1, PAAT family [KO:K09970]
Ping_2820  amino acid ABC transporter membrane protein 2, PAAT family [KO:K09971]
Ping_2824  amino acid ABC transporter membrane protein 2, PAAT family [KO:K09971]
Ping_2821  amino acid ABC transporter ATP-binding protein, PAAT family [KO:K09972] [EC:7.4.2.1]
Ping_2825  amino acid ABC transporter ATP-binding protein, PAAT family [KO:K09972] [EC:7.4.2.1]
Ping_1920  amino acid ABC transporter substrate-binding protein, PAAT family [KO:K16961]
Ping_1919  amino acid ABC transporter membrane protein, PAAT family [KO:K16962]
Ping_1918  amino acid ABC transporter ATP-binding protein, PAAT family [KO:K16963]
Ping_2833  amino acid ABC transporter substrate-binding protein, PAAT family [KO:K10022]
Ping_2831  amino acid ABC transporter membrane protein 2, PAAT family [KO:K10023]
Ping_2832  amino acid ABC transporter membrane protein 1, PAAT family [KO:K10024]
Ping_2834  amino acid ABC transporter ATP-binding protein, PAAT family [KO:K10025] [EC:7.4.2.1]
Ping_1517  amino acid ABC transporter substrate-binding protein, PAAT family [KO:K23061]
Ping_1516  amino acid ABC transporter membrane protein 1, PAAT family [KO:K23062]
Ping_1515  amino acid ABC transporter membrane protein 2, PAAT family [KO:K23063]
Ping_1514  amino acid ABC transporter ATP-binding protein, PAAT family [KO:K23064] [EC:7.4.2.1]
Ping_3536  lipoprotein, YaeC family protein [KO:K02073]
Ping_3537  ABC transporter substrate binding inner membrane protein [KO:K02072]
Ping_3538  D-methionine ABC transporter, ATPase subunit [KO:K02071]
Ping_2986  amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K11959]
Ping_2987  amino acid/amide ABC transporter membrane protein 1, HAAT family [KO:K11960]
Ping_2988  amino acid/amide ABC transporter membrane protein 2, HAAT family [KO:K11961]
Ping_2989  ABC transporter ATP-binding protein [KO:K11962]
Ping_2990  amino acid/amide ABC transporter ATP-binding protein 2, HAAT family [KO:K11963]
Ping_2192  ABC dipeptide transporter extracellular solute-binding protein, family 5 [KO:K19226]
Ping_2193  peptide ABC transporter, protein inner membrane binding component [KO:K19227]
Ping_2194  sapC; peptide ABC transporter, protein inner membrane binding component SapC [KO:K19228]
Ping_2195  ABC oligopeptide/dipeptide transporter ATP-binding protein [KO:K19229]
Ping_2196  ABC transporter ATP-binding protein predicted for antimicrobial peptide [KO:K19230]
Ping_0289  ABC transporter extracellular solute-binding protein, family 5 [KO:K13893]
Ping_0290  ABC transporter substrate binding inner membrane protein [KO:K13894]
Ping_0291  ABC transporter binding protein inner membrane protein [KO:K13895]
Ping_0292  ABC transporter foroligopeptide/dipeptide ATP-binding protein [KO:K13896]
Ping_3461  ABC-2 type transporter permease protein [KO:K09690]
Ping_3460  ABC transporter ATP-binding protein [KO:K09691] [EC:7.5.2.14]
Ping_2201  lipoprotein releasing system, transmembrane protein, LolC/E family protein [KO:K09808]
Ping_2203  lipoprotein releasing system, transmembrane protein, LolC/E family protein [KO:K09808]
Ping_2202  lipoprotein releasing system, ATP-binding protein [KO:K09810] [EC:7.6.2.-]
Ping_3021  Heme exporter protein D (CcmD) [KO:K02196]
Ping_3022  heme exporter protein CcmC [KO:K02195]
Ping_3023  heme exporter protein CcmB [KO:K02194]
Ping_3024  heme exporter protein CcmA [KO:K02193] [EC:7.6.2.5]
Ping_0396  permease YjgP/YjgQ family protein [KO:K07091]
Ping_0397  permease YjgP/YjgQ family protein [KO:K11720]
Ping_2891  ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
Ping_1425  ABC-2 type transporter for copper permease protein [KO:K19341]
Ping_1426  ABC transporter for copper ATP-binding protein [KO:K19340]
Ping_0625  ftsX; cell division protein FtsX [KO:K09811]
Ping_0624  cell division ATP-binding protein FtsE [KO:K09812]
Ping_0900  lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA [KO:K11085] [EC:7.5.2.6]
Ping_2331  ABC-type multidrug/protein/lipid transport system ATP-binding protein [KO:K18889]
Ping_2332  ABC transporter ATP-binding and permease protein [KO:K18890]
Ping_2616  ABC transporter ATP-binding protein [KO:K24821]
Ping_0691  ABC transporter ATP-binding protein [KO:K18893]
Ping_2844  ABC transporter ATP-binding protein [KO:K12541]
Ping_3453  ABC transporter for cysteine ATP-binding protein [KO:K16012]
Ping_3454  ABC transporter for cysteine ATP-binding protein [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
LinkDB

DBGET integrated database retrieval system