Entry
Name
Cellular senescence - Peromyscus leucopus (white-footed mouse)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene
114698210 Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
114684032 Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114693559 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114695335 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114688966 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
114706924 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
114703850 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114686366 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X10 [KO:K06751 ]
114687018 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114687019 H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751 ]
114687020 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114687933 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114687935 RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751 ]
114688482 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
114688490 class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751 ]
114688492 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
114688790 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114688816 LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, K-B alpha chain-like [KO:K06751 ]
114688817 H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751 ]
114682640 class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751 ]
114682644 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
114682645 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114682649 HLA class I histocompatibility antigen, alpha chain F-like isoform X3 [KO:K06751 ]
114682653 class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751 ]
114682654 HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751 ]
114682655 HLA class I histocompatibility antigen, alpha chain G [KO:K06751 ]
114682656 popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X1 [KO:K06751 ]
114682666 class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751 ]
114682671 class I histocompatibility antigen, Gogo-A*0201 alpha chain-like [KO:K06751 ]
114682672 patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751 ]
114682673 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
114682677 class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751 ]
114682685 patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751 ]
114682688 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
114705846 RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751 ]
114698355 LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 2A-like [KO:K06621 ]
114698056 Rassf5; LOW QUALITY PROTEIN: ras association domain-containing protein 5 [KO:K08015 ]
114683476 Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362 ]
114708125 Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
114704570 Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
114688301 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
114689482 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
114700921 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
114684999 Mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865 ]
114704566 Rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995 ]
114696885 Traf3ip2; LOW QUALITY PROTEIN: E3 ubiquitin ligase TRAF3IP2 [KO:K21124 ]
119089216 Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
114708955 Zfp36l2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753 ]
114686204 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
114681336 Trpv4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973 ]
114709085 Trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982 ] [EC:2.7.11.1 ]
114708260 Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
114683255 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114698768 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
114700198 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114694913 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
114684433 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
114681035 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
114708726 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
114691978 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
114708393 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
114681917 Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
114691928 LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862 ]
114700220 Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
114705743 Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
114708890 Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Munoz-Espin D, Serrano M
Title
Cellular senescence: from physiology to pathology.
Journal
Reference
Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Journal
Reference
Authors
Sharpless NE, Sherr CJ
Title
Forging a signature of in vivo senescence.
Journal
Reference
Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
Title
Senescence as a general cellular response to stress: A mini-review.
Journal
Reference
Authors
Lujambio A
Title
To clear, or not to clear (senescent cells)? That is the question.
Journal
Reference
Authors
Di Mitri D, Alimonti A
Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
Journal
Reference
Authors
Francica P, Aebersold DM, Medova M
Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
Journal
Reference
Authors
Bartling B
Title
Cellular senescence in normal and premature lung aging.
Journal
Reference
Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
Title
Programmed cell senescence during mammalian embryonic development.
Journal
Reference
Authors
Herranz N, Gallage S, Gil J
Title
TORn about SASP regulation.
Journal
Reference
Authors
Martin N, Bernard D
Title
Calcium signaling and cellular senescence.
Journal
Reference
Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
Title
Calcium homeostasis in cancer: A focus on senescence.
Journal
Reference
Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
Journal
Reference
Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
Title
Ras signaling through RASSF proteins.
Journal
Reference
Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Journal
Reference
Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Journal
Reference
Authors
Cao X, Li M
Title
A New Pathway for Senescence Regulation.
Journal
Reference
Authors
Gire V, Dulic V
Title
Senescence from G2 arrest, revisited.
Journal
Reference
Authors
Mowla SN, Lam EW, Jat PS
Title
Cellular senescence and aging: the role of B-MYB.
Journal
Reference
Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Journal
Reference
Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
Journal
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KO pathway
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