KEGG   PATHWAY: prob04971
Entry
prob04971                   Pathway                                
Name
Gastric acid secretion - Phodopus roborovskii (desert hamster)
Description
Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class
Organismal Systems; Digestive system
Pathway map
prob04971  Gastric acid secretion
prob04971

Other DBs
GO: 0001696
Organism
Phodopus roborovskii (desert hamster) [GN:prob]
Gene
127229782  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
127216331  Gast; gastrin [KO:K13768]
127228093  Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195]
127229038  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
127228774  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
127221390  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127221392  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
127221647  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
127218483  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
127228289  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
127238613  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
127237738  Ezr; ezrin [KO:K08007]
127234394  uncharacterized protein LOC127234394 [KO:K05692]
127234395  uncharacterized protein LOC127234395 [KO:K05692]
127234396  uncharacterized protein LOC127234396 [KO:K05692]
127217780  uncharacterized protein LOC127217780 [KO:K05692]
127237213  Actb; actin, cytoplasmic 1 isoform X1 [KO:K05692]
127237366  uncharacterized protein LOC127237366 [KO:K05692]
127220241  Actg1; actin, cytoplasmic 2 [KO:K05692]
127214100  uncharacterized protein LOC127214100 [KO:K05692]
127214101  uncharacterized protein LOC127214101 [KO:K05692]
127236214  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127213143  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
127224232  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
127223580  calmodulin-alpha-like [KO:K02183]
127229809  calmodulin-like protein 3 [KO:K02183]
127229810  Calml5; calmodulin-like protein 5 [KO:K02183]
127231063  Calm1; calmodulin-1 [KO:K02183]
127231862  Calml4; calmodulin-like protein 4 [KO:K02183]
127238587  Calm3; calmodulin-3 [KO:K02183]
127213474  Calml6; calmodulin-like protein 6 [KO:K02183]
127214928  Calm2; calmodulin-2 [KO:K02183]
127223054  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
127214148  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
127233865  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
127234052  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127228642  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
127229364  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
127229930  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
127227109  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
127229221  Hrh2; histamine H2 receptor [KO:K04150]
127222868  neuroendocrine secretory protein 55-like [KO:K04632]
127222787  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
127233912  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
127220711  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
127220046  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
127230359  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
127227112  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
127226028  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
127229980  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
127235293  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
127219617  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
127227016  Sst; somatostatin [KO:K05237]
127218777  Sstr2; somatostatin receptor type 2 [KO:K04218]
127216863  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
127236958  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
127214410  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
127229872  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
127229917  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
127238907  Atp4a; potassium-transporting ATPase alpha chain 1 [KO:K01542] [EC:7.2.2.19]
127220278  Atp4b; potassium-transporting ATPase subunit beta [KO:K01543] [EC:7.2.2.19]
127226792  potassium voltage-gated channel subfamily E member 2 [KO:K04896]
127227530  Kcne2; potassium voltage-gated channel subfamily E member 2 [KO:K04896]
127228580  Kcnq1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
127231733  Kcnj1; ATP-sensitive inward rectifier potassium channel 1 isoform X1 [KO:K04995]
127218734  Kcnj2; inward rectifier potassium channel 2 [KO:K04996]
127223614  Kcnj10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003]
127227551  Kcnj15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008]
127218723  Kcnj16; inward rectifier potassium channel 16 [KO:K05009]
127215341  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
127223918  Kcnk2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
127230865  Kcnk10; potassium channel subfamily K member 10 [KO:K04920]
127223286  Atp1a4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
127223608  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
127232592  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
127238563  Atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
127223511  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
127217408  Atp1b4; protein ATP1B4 [KO:K01540]
127219062  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
127238322  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
127225488  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
127236743  Slc9a4; sodium/hydrogen exchanger 4 [KO:K13961]
127231353  Ca2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
127232940  Slc26a7; anion exchange transporter [KO:K13962]
127235667  Slc4a2; anion exchange protein 2 [KO:K13855]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00388  Histamine
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
Reference
PMID:18474247
  Authors
Schubert ML, Peura DA
  Title
Control of gastric acid secretion in health and disease.
  Journal
Gastroenterology 134:1842-60 (2008)
DOI:10.1053/j.gastro.2008.05.021
Reference
PMID:9307437
  Authors
Urushidani T, Forte JG
  Title
Signal transduction and activation of acid secretion in the parietal cell.
  Journal
J Membr Biol 159:99-111 (1997)
DOI:10.1007/s002329900274
Reference
PMID:12500969
  Authors
Yao X, Forte JG
  Title
Cell biology of acid secretion by the parietal cell.
  Journal
Annu Rev Physiol 65:103-31 (2003)
DOI:10.1146/annurev.physiol.65.072302.114200
Reference
PMID:17928547
  Authors
Heitzmann D, Warth R
  Title
No potassium, no acid: K+ channels and gastric acid secretion.
  Journal
Physiology (Bethesda) 22:335-41 (2007)
DOI:10.1152/physiol.00016.2007
Reference
PMID:19889964
  Authors
Kopic S, Murek M, Geibel JP
  Title
Revisiting the parietal cell.
  Journal
Am J Physiol Cell Physiol 298:C1-C10 (2010)
DOI:10.1152/ajpcell.00478.2009
Reference
PMID:15703676
  Authors
Schubert ML
  Title
Gastric secretion.
  Journal
Curr Opin Gastroenterol 20:519-25 (2004)
DOI:10.1097/00001574-200411000-00003
Reference
PMID:16391411
  Authors
Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
  Title
From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
  Journal
J Physiol Pharmacol 56:507-30 (2005)
Reference
PMID:20148676
  Authors
Forte JG, Zhu L
  Title
Apical recycling of the gastric parietal cell H,K-ATPase.
  Journal
Annu Rev Physiol 72:273-96 (2010)
DOI:10.1146/annurev-physiol-021909-135744
Reference
PMID:18061403
  Authors
Szaszak M, Christian F, Rosenthal W, Klussmann E
  Title
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
  Journal
Cell Signal 20:590-601 (2008)
DOI:10.1016/j.cellsig.2007.10.020
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:15579540
  Authors
Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
  Title
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
  Journal
J Physiol 561:547-57 (2004)
DOI:10.1113/jphysiol.2004.075168
Reference
PMID:20331540
  Authors
Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
  Title
Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
  Journal
Acta Physiol (Oxf) 201:3-20 (2011)
DOI:10.1111/j.1748-1716.2010.02107.x
Related
pathway
prob04020  Calcium signaling pathway
prob04530  Tight junction
prob04974  Protein digestion and absorption
KO pathway
ko04971   
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