KEGG   PATHWAY: pvk00260
Entry
pvk00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas viciae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pvk00260  Glycine, serine and threonine metabolism
pvk00260

Module
pvk_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pvk00260]
pvk_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pvk00260]
pvk_M00555  Betaine biosynthesis, choline => betaine [PATH:pvk00260]
pvk_M00621  Glycine cleavage system [PATH:pvk00260]
pvk_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pvk00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas viciae [GN:pvk]
Gene
EPZ47_22815  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EPZ47_19470  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EPZ47_05435  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EPZ47_26285  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EPZ47_00165  homoserine kinase [KO:K02204] [EC:2.7.1.39]
EPZ47_20090  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
EPZ47_05440  threonine synthase [KO:K01733] [EC:4.2.3.1]
EPZ47_26295  threonine synthase [KO:K01733] [EC:4.2.3.1]
EPZ47_22825  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EPZ47_27500  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EPZ47_03535  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01620] [EC:4.1.2.48]
EPZ47_25620  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EPZ47_27485  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EPZ47_24675  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
EPZ47_17800  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EPZ47_04840  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EPZ47_11870  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EPZ47_21065  glycerate kinase [KO:K11529] [EC:2.7.1.165]
EPZ47_01630  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
EPZ47_01145  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EPZ47_08385  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
EPZ47_02625  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EPZ47_27875  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
EPZ47_23365  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EPZ47_12025  DUF1989 domain-containing protein [KO:K00605] [EC:2.1.2.10]
EPZ47_12040  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
EPZ47_23375  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EPZ47_28460  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EPZ47_12080  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EPZ47_20970  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EPZ47_29735  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EPZ47_23360  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EPZ47_28455  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EPZ47_14445  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
EPZ47_25115  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EPZ47_27655  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EPZ47_23785  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EPZ47_27650  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EPZ47_18400  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
EPZ47_18500  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
EPZ47_27515  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
EPZ47_18505  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
EPZ47_27505  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
EPZ47_27555  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
EPZ47_27550  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
EPZ47_27545  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
EPZ47_27540  electron transfer flavoprotein subunit beta [KO:K25961]
EPZ47_11960  FAD-dependent oxidoreductase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
EPZ47_27470  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
EPZ47_11970  FAD-dependent oxidoreductase [KO:K00303] [EC:1.5.3.24 1.5.3.1]
EPZ47_27480  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
EPZ47_11955  sarcosine oxidase [KO:K00305] [EC:1.5.3.24 1.5.3.1]
EPZ47_27465  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
EPZ47_11965  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
EPZ47_27475  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
EPZ47_23370  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EPZ47_27625  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EPZ47_13595  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EPZ47_17100  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EPZ47_01105  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EPZ47_10660  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
EPZ47_17320  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EPZ47_29270  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EPZ47_17325  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EPZ47_29275  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EPZ47_09075  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
EPZ47_16255  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
EPZ47_17665  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pvk00010  Glycolysis / Gluconeogenesis
pvk00020  Citrate cycle (TCA cycle)
pvk00230  Purine metabolism
pvk00250  Alanine, aspartate and glutamate metabolism
pvk00270  Cysteine and methionine metabolism
pvk00290  Valine, leucine and isoleucine biosynthesis
pvk00300  Lysine biosynthesis
pvk00330  Arginine and proline metabolism
pvk00460  Cyanoamino acid metabolism
pvk00470  D-Amino acid metabolism
pvk00564  Glycerophospholipid metabolism
pvk00620  Pyruvate metabolism
pvk00630  Glyoxylate and dicarboxylate metabolism
pvk00640  Propanoate metabolism
pvk00680  Methane metabolism
pvk00860  Porphyrin metabolism
pvk00920  Sulfur metabolism
KO pathway
ko00260   
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