Entry Name Gastric acid secretion - Rhinopithecus bieti (black snub-nosed monkey)
Description Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Rhinopithecus bieti (black snub-nosed monkey) [GN:
rbb ]
Gene 108543233 CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195 ]
108542641 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
108526885 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
108527564 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
108528737 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
108523739 ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
108514692 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
108532044 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
108544005 LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515 ] [EC:2.7.11.17 ]
108516884 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
108512486 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
108541624 GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
108519632 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
108534866 GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
108526962 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
108536823 KCNE2; potassium voltage-gated channel subfamily E member 2 [KO:K04896 ]
108538141 KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926 ]
108529087 KCNJ1; ATP-sensitive inward rectifier potassium channel 1 isoform X1 [KO:K04995 ]
108524044 KCNJ10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003 ]
108535005 KCNJ15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008 ]
108523232 KCNJ16; inward rectifier potassium channel 16 isoform X1 [KO:K05009 ]
108528238 KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913 ]
108522796 KCNK10; potassium channel subfamily K member 10 isoform X1 [KO:K04920 ]
108522426 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540 ]
108514361 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
108527281 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
108524081 SLC9A4; LOW QUALITY PROTEIN: sodium/hydrogen exchanger 4 [KO:K13961 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Schubert ML, Peura DA
Title Control of gastric acid secretion in health and disease.
Journal Reference Authors Urushidani T, Forte JG
Title Signal transduction and activation of acid secretion in the parietal cell.
Journal Reference Authors Yao X, Forte JG
Title Cell biology of acid secretion by the parietal cell.
Journal Reference Authors Heitzmann D, Warth R
Title No potassium, no acid: K+ channels and gastric acid secretion.
Journal Reference Authors Kopic S, Murek M, Geibel JP
Title Revisiting the parietal cell.
Journal Reference Authors Schubert ML
Title Gastric secretion.
Journal Reference Authors Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
Title From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
Journal J Physiol Pharmacol 56:507-30 (2005)
Reference Authors Forte JG, Zhu L
Title Apical recycling of the gastric parietal cell H,K-ATPase.
Journal Reference Authors Szaszak M, Christian F, Rosenthal W, Klussmann E
Title Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Journal Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
Title Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Journal Reference Authors Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
Title Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
Journal Related rbb04974 Protein digestion and absorption
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