KEGG   PATHWAY: rel00260
Entry
rel00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium etli bv. mimosae Mim1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rel00260  Glycine, serine and threonine metabolism
rel00260

Module
rel_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rel00260]
rel_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rel00260]
rel_M00555  Betaine biosynthesis, choline => betaine [PATH:rel00260]
rel_M00621  Glycine cleavage system [PATH:rel00260]
rel_M00919  Ectoine degradation, ectoine => aspartate [PATH:rel00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium etli bv. mimosae Mim1 [GN:rel]
Gene
REMIM1_CH03840  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
REMIM1_PE00375  aspartate/glutamate/uridylate kinase protein [KO:K00928] [EC:2.7.2.4]
REMIM1_CH04217  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
REMIM1_CH01931  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
REMIM1_CH00979  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
REMIM1_CH00999  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
REMIM1_CH03639  ltaE; low-specificity threonine aldolase [KO:K01620] [EC:4.1.2.48]
REMIM1_CH01523  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
REMIM1_PF00835  sgaA; serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
REMIM1_CH00187  ghrA-1; bifunctional glyoxylate/hydroxypyruvate reductase A 1 [KO:K12972] [EC:1.1.1.79 1.1.1.81]
REMIM1_PF00578  ghrA-2; bifunctional glyoxylate/hydroxypyruvate reductase A 2 [KO:K12972] [EC:1.1.1.79 1.1.1.81]
REMIM1_CH01839  ttuD; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
REMIM1_CH00177  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
REMIM1_CH02365  phosphoglycerate mutase protein [KO:K01834] [EC:5.4.2.11]
REMIM1_CH03519  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
REMIM1_PF00924  D-2-hydroxyacid dehydrogenase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
REMIM1_PF00530  D-2-hydroxyacid dehydrogenase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
REMIM1_CH03520  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
REMIM1_CH02837  phosphoserine phosphatase SerB-like protein [KO:K01079] [EC:3.1.3.3]
REMIM1_CH02993  bifunctional 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase protein [KO:K00639] [EC:2.3.1.29]
REMIM1_CH02992  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
REMIM1_PE00265  hemA-2; 5-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]
REMIM1_CH03935  hemA-1; 5-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]
REMIM1_PF00234  hemA-3; 5-aminolevulinate synthase 3 [KO:K00643] [EC:2.3.1.37]
REMIM1_PD00425  amine oxidase protein [KO:K00274] [EC:1.4.3.4]
REMIM1_CH02253  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
REMIM1_CH02251  gcvT; aminomethyltransferase (glycine-cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
REMIM1_PD00428  glycine-cleavage system T protein [KO:K00605] [EC:2.1.2.10]
REMIM1_PD00437  glycine-cleavage system T protein [KO:K00605] [EC:2.1.2.10]
REMIM1_CH01997  lpdA-1; dihydrolipoamide dehydrogenase 1 [KO:K00382] [EC:1.8.1.4]
REMIM1_PF00816  lpdA-2; dihydrolipoamide dehydrogenase 2 [KO:K00382] [EC:1.8.1.4]
REMIM1_PB00074  lpdV; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
REMIM1_CH03974  dihydrolipoamide dehydrogenase protein [KO:K00382] [EC:1.8.1.4]
REMIM1_CH02252  gcvH; glycine-cleavage system protein H [KO:K02437]
REMIM1_CH01421  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
REMIM1_PE00462  betA-2; choline dehydrogenase 2 [KO:K00108] [EC:1.1.99.1]
REMIM1_CH01138  betA-1; choline dehydrogenase 1 [KO:K00108] [EC:1.1.99.1]
REMIM1_CH01139  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
REMIM1_CH00916  dioxygenase protein [KO:K00479] [EC:1.14.13.251]
REMIM1_PF00520  ring-hydroxylating dioxygenase protein [KO:K00479] [EC:1.14.13.251]
REMIM1_PF00519  ferredoxin reductase-type FAD/NAD-binding protein [KO:K21832] [EC:1.14.13.251]
REMIM1_CH03676  soxA-1; sarcosine oxidase alpha subunit SoxA 1 [KO:K00302] [EC:1.5.3.24 1.5.3.1]
REMIM1_CH03678  soxB-1; sarcosine oxidase beta subunit SoxB 1 [KO:K00303] [EC:1.5.3.24 1.5.3.1]
REMIM1_CH03675  soxG-1; sarcosine oxidase gamma subunit SoxG 1 [KO:K00305] [EC:1.5.3.24 1.5.3.1]
REMIM1_CH03677  soxD-1; sarcosine oxidase delta subunit SoxD 1 [KO:K00304] [EC:1.5.3.24 1.5.3.1]
REMIM1_CH02223  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
REMIM1_CH02032  tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
REMIM1_CH03608  pyridoxal phosphate-dependent serine/threonine dehydratase protein [KO:K01754] [EC:4.3.1.19]
REMIM1_PF00734  eutB-3; ectoine utilization protein EutB 3 [KO:K01754] [EC:4.3.1.19]
REMIM1_CH01803  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
REMIM1_PC00119  eutB-1; ectoine utilization protein EutB 1 [KO:K01754] [EC:4.3.1.19]
REMIM1_PC00146  eutB-2; ectoine utilization protein EutB 2 [KO:K01754] [EC:4.3.1.19]
REMIM1_CH04209  pyridoxal phosphate-dependent serine/threonine dehydratase protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
REMIM1_PB00191  alanine racemase domain-containing protein [KO:K01753] [EC:4.3.1.18]
REMIM1_CH00022  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
REMIM1_CH00021  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
REMIM1_PE00373  ectB; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
REMIM1_CH00939  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
REMIM1_PF00736  eutD-3; ectoine utilization protein EutD 3 [KO:K15783] [EC:3.5.4.44]
REMIM1_PC00118  eutD-1; ectoine utilization protein EutD 1 [KO:K15783] [EC:3.5.4.44]
REMIM1_PC00148  eutD-2; ectoine utilization protein EutD 2 [KO:K15783] [EC:3.5.4.44]
REMIM1_PC00109  ectoine utilization EutD protein [KO:K15783] [EC:3.5.4.44]
REMIM1_PC00149  ectoine utilization EutD protein [KO:K15783] [EC:3.5.4.44]
REMIM1_PE00247  ectoine utilization EutD protein [KO:K15783] [EC:3.5.4.44]
REMIM1_PF00737  eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
REMIM1_PF00725  aminotransferase class 3 protein [KO:K15785] [EC:2.6.1.76]
REMIM1_PE00251  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
REMIM1_PC00166  pyridoxal phosphate-dependent aminotransferase protein [KO:K15785] [EC:2.6.1.76]
REMIM1_PC00124  pyridoxal phosphate-dependent aminotransferase protein [KO:K15785] [EC:2.6.1.76]
REMIM1_PF00726  succinate-semialdehyde dehydrogenase (NADP+) protein [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rel00010  Glycolysis / Gluconeogenesis
rel00020  Citrate cycle (TCA cycle)
rel00230  Purine metabolism
rel00250  Alanine, aspartate and glutamate metabolism
rel00270  Cysteine and methionine metabolism
rel00290  Valine, leucine and isoleucine biosynthesis
rel00300  Lysine biosynthesis
rel00330  Arginine and proline metabolism
rel00460  Cyanoamino acid metabolism
rel00470  D-Amino acid metabolism
rel00564  Glycerophospholipid metabolism
rel00600  Sphingolipid metabolism
rel00620  Pyruvate metabolism
rel00630  Glyoxylate and dicarboxylate metabolism
rel00640  Propanoate metabolism
rel00680  Methane metabolism
rel00860  Porphyrin metabolism
rel00920  Sulfur metabolism
KO pathway
ko00260   
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