KEGG   PATHWAY: rn00790
Entry
rn00790                     Pathway                                
Name
Folate biosynthesis
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rn00790  Folate biosynthesis
rn00790

Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:rn00790]
M00840  Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF [PATH:rn00790]
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF [PATH:rn00790]
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:rn00790]
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4 [PATH:rn00790]
M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:rn00790]
Other DBs
GO: 0046656
Reaction
R00425  GTP 7,8-8,9-dihydrolase (diphosphate-forming)
R00428  GTP 8,9-hydrolase
R00936  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00937  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00939  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R00940  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R00942  tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
R01716  chorismate:L-glutamine aminotransferase
R01793  5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase
R01794  5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
R01812  5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
R01813  tetrahydrobiopterin:NADP+ oxidoreductase
R02235  dihydrofolate:NAD+ oxidoreductase
R02236  dihydrofolate:NADP+ oxidoreductase
R02237  7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
R02975  7,8-dihydrobiopterin:NADP+ oxidoreductase
R03066  6-(hydroxymethyl)-7,8-dihydropterin:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
R03067  (7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase
R03388  5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase
R03503  ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
R03504  7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
R03984  pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
R04241  tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)
R04242  tetrahydropteroyl-poly-gamma-glutamate gamma-glutamylhydrolase
R04285  6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
R04286  2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate lyase
R04620  7,8-dihydroneopterin-3'-triphosphate phosphohydrolase (alkaline optimum)
R04621   
R04622   
R04638  7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase
R04639  2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate hydrolase
R04734  4a-hydroxytetrahydrobiopterin hydro-lyase
R05046  formamidopyrimidine nucleoside triphosphate amidohydrolase
R05048  2,5-diaminopyrimidine nucleoside triphosphate mutase
R05553  4-amino-4-deoxychorismate pyruvate-lyase
R07211  L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)
R07212  L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase(3-hydroxylating)
R07213  L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)
R07605  7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase
R08208  tetrahydrobiopterin:NADP+ oxidoreductase (6-pyruvoyltetrahydropterin-forming)
R09394  GTP 3',8-cyclase [(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate-forming]
R09395  thiocarboxylated molybdopterin synthase:cyclic pyranopterin phosphate sulfurtransferase
R09594  tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming)
R09726  ATP:molybdopterin adenylyltransferase
R09735  adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming)
R09959  7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming)
R09978  7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming)
R09990  L-threo-tetrahydrobiopterin:NADP+ oxidoreductase
R10002  6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase
R10339  (7,8-dihydropterin-6-yl)methyl-diphosphate:4-(beta-D-ribofuranosyl)aniline-5'-phosphate 6-hydroxymethyl-7,8-dihydropterintransferase
R10344  7,8-dihydroneopterin 2',3'-cyclic phosphate 3'-phosphodiesterase
R10345  7,8-dihydroneopterin 2',3'-cyclic phosphate 2'-phosphodiesterase
R10348  GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing)
R10802  5,6,7,8-tetrahydromethanopterin:acceptor 5,6-oxidoreductase
R11019  5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase
R11037  7,8-dihydroneopterin:oxygen oxidoreductase
R11072  2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one cyclohydrolase
R11073  7,8-dihydroneopterin 2'-epimerase
R11082  7,8-dihydroneopterin 3'-triphosphate 2'-epimerase
R11102  5-phospho-alpha-D-ribose-1-diphosphate:4-hydroxybenzoate 5-phospho-beta-D-ribofuranosyltransferase (decarboxylating)
R11372  (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate lyase (cyclic pyranopterin phosphate-forming)
R11581  GTP:molybdenum cofactor guanylyltransferase
R11582  CTP:molybdenum cofactor cytidylyltransferase
R11583  L-cysteine:molybdenum cofactor sulfurtransferase
R11718  7,8-dihydroneopterin-3'-phosphate glycolaldehyde-phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
R11719  7,8-dihydroneopterin-3'-triphosphate glycolaldehyde-phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
R11763  6-(1'-hydroxy-2'-oxopropyl)-tetrahydropterin:NADP+ oxidoreductase
R11764  tetrahydrobiopterin:NADP+ oxidoreductase [6-(1'-hydroxy-2'-oxopropyl)-tetrahydropterin-forming]
R11765  tetrahydrobiopterin:NADP+ oxidoreductase (7,8-dihydrobiopterin-forming)
R11766   
R11767   
R12644  7,8-dihydrobiopterin:NADP+ oxidoreductase
R12939  chorismate:L-glutamine aminotransferase (2-amino-4-deoxychorismate-forming)
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
rn00230  Purine metabolism
rn00362  Benzoate degradation
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00670  One carbon pool by folate
rn00680  Methane metabolism
KO pathway
ko00790   
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