KEGG   PATHWAY: rok00260
Entry
rok00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Roseovarius sp. AK1035
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rok00260  Glycine, serine and threonine metabolism
rok00260

Module
rok_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rok00260]
rok_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:rok00260]
rok_M00621  Glycine cleavage system [PATH:rok00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Roseovarius sp. AK1035 [GN:rok]
Gene
RAK1035_0061  Aspartokinase [KO:K00928] [EC:2.7.2.4]
RAK1035_1010  Aspartokinase associated with ectoine biosynthesis [KO:K00928] [EC:2.7.2.4]
RAK1035_1242  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
RAK1035_3825  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
RAK1035_0305  Threonine synthase [KO:K01733] [EC:4.2.3.1]
RAK1035_1803  Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
RAK1035_0444  Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
RAK1035_0118  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
RAK1035_2660  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
RAK1035_2561  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_1251  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_0940  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_2341  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_0425  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RAK1035_0699  D-glycerate 2-kinase [KO:K11529] [EC:2.7.1.165]
RAK1035_3720  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
RAK1035_1337  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
RAK1035_1336  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
RAK1035_1335  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
RAK1035_1022  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
RAK1035_1023  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
RAK1035_3652  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
RAK1035_3763  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
RAK1035_2541  Glycine dehydrogenase, decarboxylating (glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]
RAK1035_2525  Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
RAK1035_2878  Sarcosine oxidase alpha subunit [KO:K00605] [EC:2.1.2.10]
RAK1035_2887  Sarcosine oxidase alpha subunit [KO:K00605] [EC:2.1.2.10]
RAK1035_2452  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
RAK1035_3780  Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
RAK1035_0666  Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase [KO:K00382] [EC:1.8.1.4]
RAK1035_2526  Glycine cleavage system H protein [KO:K02437]
RAK1035_0496  Creatinase [KO:K08688] [EC:3.5.3.3]
RAK1035_1299  Creatinase [KO:K08688] [EC:3.5.3.3]
RAK1035_0647  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
RAK1035_2236  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
RAK1035_1554  Dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
RAK1035_1955  Sarcosine dehydrogenase [KO:K00315] [EC:1.5.8.4]
RAK1035_3049  Sarcosine dehydrogenase [KO:K00315] [EC:1.5.8.4]
RAK1035_3051  Sarcosine dehydrogenase [KO:K00315] [EC:1.5.8.4]
RAK1035_0653  Sarcosine dehydrogenase [KO:K00315] [EC:1.5.8.4]
RAK1035_0017  Sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
RAK1035_0019  Sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
RAK1035_0016  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
RAK1035_0018  Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
RAK1035_0712  L-serine dehydratase, beta subunit [KO:K01752] [EC:4.3.1.17]
RAK1035_0052  Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
RAK1035_0497  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
RAK1035_0973  Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
RAK1035_1102  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
RAK1035_0629  Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
RAK1035_2798  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
RAK1035_3523  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
RAK1035_1008  Diaminobutyrate-pyruvate aminotransferase [KO:K00836] [EC:2.6.1.76]
RAK1035_1007  L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
RAK1035_1009  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
RAK1035_0974  Xaa-Pro aminopeptidase [KO:K15783] [EC:3.5.4.44]
RAK1035_0969  Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase [KO:K15785] [EC:2.6.1.76]
RAK1035_0970  Aldehyde dehydrogenase B [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rok00010  Glycolysis / Gluconeogenesis
rok00020  Citrate cycle (TCA cycle)
rok00230  Purine metabolism
rok00250  Alanine, aspartate and glutamate metabolism
rok00270  Cysteine and methionine metabolism
rok00290  Valine, leucine and isoleucine biosynthesis
rok00300  Lysine biosynthesis
rok00330  Arginine and proline metabolism
rok00460  Cyanoamino acid metabolism
rok00470  D-Amino acid metabolism
rok00564  Glycerophospholipid metabolism
rok00620  Pyruvate metabolism
rok00630  Glyoxylate and dicarboxylate metabolism
rok00640  Propanoate metabolism
rok00680  Methane metabolism
rok00860  Porphyrin metabolism
rok00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system