KEGG   PATHWAY: rpe02010
Entry
rpe02010                    Pathway                                
Name
ABC transporters - Rhodopseudomonas palustris BisA53
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
rpe02010  ABC transporters
rpe02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Rhodopseudomonas palustris BisA53 [GN:rpe]
Gene
RPE_1760  sulfate ABC transporter, periplasmic sulfate-binding protein [KO:K02048]
RPE_1768  sulfate ABC transporter, periplasmic sulfate-binding protein [KO:K23163]
RPE_1759  sulfate ABC transporter, inner membrane subunit CysT [KO:K02046]
RPE_1769  sulfate ABC transporter, inner membrane subunit CysT [KO:K02046]
RPE_1770  sulfate ABC transporter, inner membrane subunit CysW [KO:K02047]
RPE_1758  sulfate ABC transporter, inner membrane subunit CysW [KO:K02047]
RPE_1771  sulfate ABC transporter, ATPase subunit [KO:K02045] [EC:7.3.2.3]
RPE_4638  ABC-type nitrate transport system periplasmic component [KO:K15576]
RPE_1265  ABC-type nitrate transport system periplasmic component [KO:K15576]
RPE_4637  nitrate ABC transporter, inner membrane subunit [KO:K15577]
RPE_1264  nitrate ABC transporter, inner membrane subunit [KO:K15577]
RPE_1263  nitrate ABC transporter, ATPase subunits C and D [KO:K15578] [EC:7.3.2.4]
RPE_4636  ABC transporter related [KO:K15578] [EC:7.3.2.4]
RPE_3192  aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein [KO:K15553]
RPE_3205  aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein [KO:K15553]
RPE_3194  binding-protein-dependent transport systems inner membrane component [KO:K15554]
RPE_3195  ABC transporter related [KO:K15555] [EC:7.6.2.14]
RPE_0764  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
RPE_0763  molybdate ABC transporter, inner membrane subunit [KO:K02018]
RPE_0762  molybdate ABC transporter, ATPase subunit [KO:K02017] [EC:7.3.2.5]
RPE_4073  extracellular solute-binding protein, family 1 [KO:K02012]
RPE_4074  binding-protein-dependent transport systems inner membrane component [KO:K02011]
RPE_2015  extracellular solute-binding protein, family 1 [KO:K11073]
RPE_4081  binding-protein-dependent transport systems inner membrane component [KO:K11074]
RPE_4082  binding-protein-dependent transport systems inner membrane component [KO:K11075]
RPE_4083  spermidine/putrescine ABC transporter ATPase subunit [KO:K11076] [EC:7.6.2.16]
RPE_2201  Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845 K05846]
RPE_2202  ABC transporter related [KO:K05847] [EC:7.6.2.9]
RPE_3687  ABC transporter related [KO:K10112] [EC:7.5.2.-]
RPE_1739  Mammalian cell entry related domain protein [KO:K02067]
RPE_1473  Mammalian cell entry related domain protein [KO:K02067]
RPE_1471  protein of unknown function DUF140 [KO:K02066]
RPE_1737  protein of unknown function DUF140 [KO:K02066]
RPE_1738  ABC transporter related [KO:K02065]
RPE_1472  ABC transporter related [KO:K02065]
RPE_1384  extracellular solute-binding protein, family 1 [KO:K17321]
RPE_1381  binding-protein-dependent transport systems inner membrane component [KO:K17322]
RPE_1382  binding-protein-dependent transport systems inner membrane component [KO:K17323]
RPE_1379  ABC transporter related [KO:K17324]
RPE_1380  ABC transporter related [KO:K17325]
RPE_0440  extracellular solute-binding protein, family 1 [KO:K05813]
RPE_0544  extracellular solute-binding protein, family 1 [KO:K05813]
RPE_0438  binding-protein-dependent transport systems inner membrane component [KO:K05814]
RPE_0437  binding-protein-dependent transport systems inner membrane component [KO:K05815]
RPE_0436  ABC transporter related [KO:K05816] [EC:7.6.2.10]
RPE_2451  ABC-type phosphate transport system periplasmic component-like protein [KO:K02040]
RPE_4891  phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
RPE_4890  phosphate ABC transporter, inner membrane subunit PstC [KO:K02037]
RPE_4889  phosphate ABC transporter, inner membrane subunit PstA [KO:K02038]
RPE_4888  phosphate ABC transporter, ATPase subunit [KO:K02036] [EC:7.3.2.1]
RPE_3114  phosphonate ABC transporter, periplasmic phosphonate-binding protein [KO:K02044]
RPE_2051  phosphonate ABC transporter, periplasmic phosphonate-binding protein [KO:K02044]
RPE_2048  phosphonate ABC transporter, inner membrane subunit [KO:K02042]
RPE_3112  phosphonate ABC transporter, inner membrane subunit [KO:K02042]
RPE_3113  phosphonate ABC transporter, inner membrane subunit [KO:K02042]
RPE_2049  phosphonate ABC transporter, inner membrane subunit [KO:K02042]
RPE_2050  phosphonate ABC transporter, ATPase subunit [KO:K02041] [EC:7.3.2.2]
RPE_3115  phosphonate ABC transporter, ATPase subunit [KO:K02041] [EC:7.3.2.2]
RPE_2729  cationic amino acid ABC transporter, periplasmic binding protein [KO:K09969]
RPE_0535  extracellular solute-binding protein, family 3 [KO:K09969]
RPE_2730  polar amino acid ABC transporter, inner membrane subunit [KO:K09970]
RPE_2731  polar amino acid ABC transporter, inner membrane subunit [KO:K09971]
RPE_2732  ABC transporter related [KO:K09972] [EC:7.4.2.1]
RPE_3786  Extracellular ligand-binding receptor [KO:K01999]
RPE_3787  Extracellular ligand-binding receptor [KO:K01999]
RPE_1693  Extracellular ligand-binding receptor [KO:K01999]
RPE_3053  ABC transporter substrate-binding protein [KO:K01999]
RPE_3800  Extracellular ligand-binding receptor [KO:K01999]
RPE_4231  putative branched-chain amino acid ABC transport system substrate-binding protein [KO:K01999]
RPE_4221  ABC transporter, periplasmic branched chain amino acid binding protein [KO:K01999]
RPE_1647  Extracellular ligand-binding receptor [KO:K01999]
RPE_4215  Extracellular ligand-binding receptor [KO:K01999]
RPE_0999  Extracellular ligand-binding receptor [KO:K01999]
RPE_0848  Extracellular ligand-binding receptor [KO:K01999]
RPE_0546  Extracellular ligand-binding receptor [KO:K01999]
RPE_0593  Extracellular ligand-binding receptor [KO:K01999]
RPE_1390  Extracellular ligand-binding receptor [KO:K01999]
RPE_3211  Extracellular ligand-binding receptor [KO:K01999]
RPE_3789  Extracellular ligand-binding receptor [KO:K01999]
RPE_0264  conserved hypothetical protein [KO:K01999]
RPE_3555  Extracellular ligand-binding receptor [KO:K01999]
RPE_3788  Extracellular ligand-binding receptor [KO:K01999]
RPE_3854  ABC-type branched-chain amino acid transport systems periplasmic component [KO:K01999]
RPE_1651  inner-membrane translocator [KO:K01997]
RPE_1694  inner-membrane translocator [KO:K01997]
RPE_3052  inner-membrane translocator [KO:K01997]
RPE_3784  inner-membrane translocator [KO:K01997]
RPE_3795  inner-membrane translocator [KO:K01997]
RPE_4213  inner-membrane translocator [KO:K01997]
RPE_4222  inner-membrane translocator [KO:K01997]
RPE_4229  inner-membrane translocator [KO:K01997]
RPE_3853  inner-membrane translocator [KO:K01997]
RPE_1000  inner-membrane translocator [KO:K01997]
RPE_0594  inner-membrane translocator [KO:K01997]
RPE_1387  inner-membrane translocator [KO:K01997]
RPE_3209  inner-membrane translocator [KO:K01997]
RPE_0595  ABC transporter related [KO:K01995 K01998]
RPE_3796  ABC transporter related [KO:K01995 K01998]
RPE_3208  ABC transporter related [KO:K01995 K01998]
RPE_1001  inner-membrane translocator [KO:K01998]
RPE_1386  inner-membrane translocator [KO:K01998]
RPE_1650  inner-membrane translocator [KO:K01998]
RPE_1695  inner-membrane translocator [KO:K01998]
RPE_3051  inner-membrane translocator [KO:K01998]
RPE_3785  inner-membrane translocator [KO:K01998]
RPE_4212  inner-membrane translocator [KO:K01998]
RPE_4223  inner-membrane translocator [KO:K01998]
RPE_4230  inner-membrane translocator [KO:K01998]
RPE_1649  ABC transporter related [KO:K01995]
RPE_1696  ABC transporter related [KO:K01995]
RPE_3055  ABC transporter related [KO:K01995]
RPE_4224  ABC transporter related [KO:K01995]
RPE_3782  ABC transporter related [KO:K01995]
RPE_4226  ABC transporter related [KO:K01995]
RPE_3851  ABC transporter related [KO:K01995]
RPE_1002  ABC transporter related [KO:K01995]
RPE_1389  ABC transporter related [KO:K01995]
RPE_4211  ABC transporter related [KO:K01995]
RPE_1003  ABC transporter related [KO:K01996]
RPE_1388  ABC transporter related [KO:K01996]
RPE_1648  ABC transporter related [KO:K01996]
RPE_1697  ABC transporter related [KO:K01996]
RPE_0596  ABC transporter related [KO:K01996]
RPE_3207  ABC transporter related [KO:K01996]
RPE_3054  ABC transporter related [KO:K01996]
RPE_3783  ABC transporter related [KO:K01996]
RPE_3797  ABC transporter related [KO:K01996]
RPE_3850  ABC transporter related [KO:K01996]
RPE_4210  ABC transporter related [KO:K01996]
RPE_4225  ABC transporter related [KO:K01996]
RPE_4232  ABC transporter related [KO:K01996]
RPE_3180  NLPA lipoprotein [KO:K02073]
RPE_3182  lipoprotein, YaeC family [KO:K02073]
RPE_3183  binding-protein-dependent transport systems inner membrane component [KO:K02072]
RPE_3184  ABC transporter related [KO:K02071]
RPE_4602  amide-UreA binding protein [KO:K11959]
RPE_3741  branched-chain amino acid uptake ABC transporter periplasmic solute-binding protein precursor [KO:K11959]
RPE_4601  inner-membrane translocator [KO:K11960]
RPE_3740  inner-membrane translocator [KO:K11960]
RPE_4600  inner-membrane translocator [KO:K11961]
RPE_3739  inner-membrane translocator [KO:K11961]
RPE_3738  ABC transporter related [KO:K11962]
RPE_4599  ABC transporter related [KO:K11962]
RPE_3737  ABC transporter related [KO:K11963]
RPE_4598  ABC transporter related [KO:K11963]
RPE_3766  extracellular solute-binding protein, family 5 [KO:K13893]
RPE_3767  extracellular solute-binding protein [KO:K13893]
RPE_3765  binding-protein-dependent transport systems inner membrane component [KO:K13894]
RPE_3764  binding-protein-dependent transport systems inner membrane component [KO:K13895]
RPE_3761  ABC transporter related [KO:K13896]
RPE_2840  periplasmic solute binding protein [KO:K11707]
RPE_2838  ABC-3 protein [KO:K11708]
RPE_2837  ABC-3 protein [KO:K11709]
RPE_2839  ABC transporter related [KO:K11710] [EC:7.2.2.5]
RPE_1970  cobalamin (vitamin B12) biosynthesis CbiM protein [KO:K02007]
RPE_4294  cobalamin (vitamin B12) biosynthesis CbiM protein [KO:K02007]
RPE_4292  cobalt ABC transporter, inner membrane subunit CbiQ [KO:K02008]
RPE_1968  cobalt ABC transporter, inner membrane subunit CbiQ [KO:K02008]
RPE_4291  ABC transporter related [KO:K02006]
RPE_4295  conserved hypothetical protein [KO:K10094]
RPE_1971  ABC-type Co2+ transport system, periplasmic component [KO:K10094]
RPE_1969  conserved hypothetical protein [KO:K16915]
RPE_4293  conserved hypothetical protein [KO:K16915]
RPE_4249  ABC-2 type transporter [KO:K09690]
RPE_4248  ABC transporter related [KO:K09691] [EC:7.5.2.14]
RPE_2545  lipoprotein releasing system, transmembrane protein, LolC/E family [KO:K09808]
RPE_3953  protein of unknown function DUF214 [KO:K09808]
RPE_2546  ABC transporter related [KO:K09810] [EC:7.6.2.-]
RPE_3952  ABC transporter related [KO:K09810] [EC:7.6.2.-]
RPE_0314  Heme exporter protein D (CcmD) [KO:K02196]
RPE_0313  heme exporter protein CcmC [KO:K02195]
RPE_0312  heme exporter protein CcmB [KO:K02194]
RPE_0311  heme exporter protein CcmA [KO:K02193] [EC:7.6.2.5]
RPE_3292  permease YjgP/YjgQ family protein [KO:K07091]
RPE_3293  permease YjgP/YjgQ family protein [KO:K11720]
RPE_0429  ABC transporter related [KO:K06861] [EC:7.5.2.5]
RPE_3098  nitrous oxide metabolic protein [KO:K19341]
RPE_3097  ABC transporter related [KO:K19340]
RPE_4831  protein of unknown function DUF214 [KO:K09811]
RPE_4832  cell division ATP-binding protein FtsE [KO:K09812]
RPE_1447  ABC transporter related [KO:K11085] [EC:7.5.2.6]
RPE_1085  type I secretion system ATPase [KO:K11004]
RPE_2007  ABC transporter related [KO:K24821]
RPE_3511  type I secretion system ATPase [KO:K12536]
RPE_1008  type I secretion system ATPase [KO:K12536]
RPE_4689  ABC transporter domain protein [KO:K02471]
RPE_0887  SbmABacA family protein [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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