KEGG   PATHWAY: rtu00260
Entry
rtu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium tumorigenes
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rtu00260  Glycine, serine and threonine metabolism
rtu00260

Module
rtu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rtu00260]
rtu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rtu00260]
rtu_M00555  Betaine biosynthesis, choline => betaine [PATH:rtu00260]
rtu_M00621  Glycine cleavage system [PATH:rtu00260]
rtu_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:rtu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium tumorigenes [GN:rtu]
Gene
PR017_13635  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PR017_15435  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PR017_08145  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PR017_02450  homoserine kinase [KO:K02204] [EC:2.7.1.39]
PR017_02505  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PR017_12110  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PR017_04610  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PR017_26135  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PR017_28165  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PR017_19025  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
PR017_11475  glycerate kinase [KO:K11529] [EC:2.7.1.165]
PR017_16375  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PR017_03195  phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
PR017_23640  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PR017_27090  NAD(P)-dependent oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PR017_23635  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
PR017_08945  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
PR017_14165  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
PR017_26980  NAD(P)/FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
PR017_07320  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PR017_16595  aminomethyltransferase family protein [KO:K00605] [EC:2.1.2.10]
PR017_16730  DUF1989 domain-containing protein [KO:K00605] [EC:2.1.2.10]
PR017_07310  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
PR017_14275  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PR017_06280  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PR017_07315  gcvH; glycine cleavage system protein GcvH [KO:K02437]
PR017_04120  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
PR017_02950  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PR017_02965  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PR017_02210  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
PR017_02215  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
PR017_27300  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
PR017_11065  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
PR017_26730  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
PR017_12280  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PR017_12290  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PR017_12275  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PR017_12285  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PR017_07175  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
PR017_05890  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
PR017_11930  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
PR017_19400  alanine racemase [KO:K01753] [EC:4.3.1.18]
PR017_15695  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
PR017_15690  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rtu00010  Glycolysis / Gluconeogenesis
rtu00020  Citrate cycle (TCA cycle)
rtu00230  Purine metabolism
rtu00250  Alanine, aspartate and glutamate metabolism
rtu00270  Cysteine and methionine metabolism
rtu00290  Valine, leucine and isoleucine biosynthesis
rtu00300  Lysine biosynthesis
rtu00330  Arginine and proline metabolism
rtu00460  Cyanoamino acid metabolism
rtu00470  D-Amino acid metabolism
rtu00564  Glycerophospholipid metabolism
rtu00600  Sphingolipid metabolism
rtu00620  Pyruvate metabolism
rtu00630  Glyoxylate and dicarboxylate metabolism
rtu00640  Propanoate metabolism
rtu00680  Methane metabolism
rtu00860  Porphyrin metabolism
rtu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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