KEGG   PATHWAY: salf00260
Entry
salf00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces alboflavus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
salf00260  Glycine, serine and threonine metabolism
salf00260

Module
salf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:salf00260]
salf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:salf00260]
salf_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:salf00260]
salf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:salf00260]
salf_M00621  Glycine cleavage system [PATH:salf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces alboflavus [GN:salf]
Gene
SMD44_04682  lysC; putative Aspartokinase [KO:K00928] [EC:2.7.2.4]
SMD44_04684  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SMD44_02944  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SMD44_05899  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SMD44_05901  thrB1; serine kinase [KO:K00872] [EC:2.7.1.39]
SMD44_05900  thrC; L-threonine synthase [KO:K01733] [EC:4.2.3.1]
SMD44_03860  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SMD44_03024  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SMD44_08860  thrC; L-threonine synthase [KO:K01733] [EC:4.2.3.1]
SMD44_01035  ltaE; threonine aldolase [KO:K01620] [EC:4.1.2.48]
SMD44_05909  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SMD44_06070  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SMD44_05409  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SMD44_01087  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SMD44_02353  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
SMD44_07011  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
SMD44_03907  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SMD44_04405  hypothetical protein [KO:K15633] [EC:5.4.2.12]
SMD44_06126  serA; 3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SMD44_07951  serA; 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SMD44_03766  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SMD44_01939  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SMD44_04287  serB; hydrolase [KO:K01079] [EC:3.1.3.3]
SMD44_07413  kbl; 2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
SMD44_07412  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SMD44_00154  hypothetical protein [KO:K00274] [EC:1.4.3.4]
SMD44_06707  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
SMD44_01388  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SMD44_06072  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
SMD44_01160  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SMD44_02387  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SMD44_06071  gcvH; glycine cleavage system protein H [KO:K02437]
SMD44_07283  amino acid oxidase [KO:K00273] [EC:1.4.3.3]
SMD44_07808  putative Glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
SMD44_07012  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SMD44_05360  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SMD44_06273  betB; phenylacetaldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SMD44_06286  betB; gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SMD44_01424  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
SMD44_01425  methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
SMD44_05398  methyltransferase [KO:K18897] [EC:2.1.1.157]
SMD44_06865  SAM-dependent methyltransferase [KO:K24071] [EC:2.1.1.156 2.1.1.157]
SMD44_03430  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SMD44_04283  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
SMD44_06069  serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SMD44_05553  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SMD44_02236  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SMD44_p10060  hypothetical protein [KO:K01695] [EC:4.2.1.20]
SMD44_02237  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
SMD44_02014  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
SMD44_06427  2,4-diaminobutyrate 4-aminotransferase [KO:K00836] [EC:2.6.1.76]
SMD44_02013  hypothetical protein [KO:K06718] [EC:2.3.1.178]
SMD44_02015  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
SMD44_02016  ectD; multidrug DMT transporter permease [KO:K10674] [EC:1.14.11.55]
SMD44_02200  ddc; amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
SMD44_03080  ddc; pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
salf00010  Glycolysis / Gluconeogenesis
salf00020  Citrate cycle (TCA cycle)
salf00230  Purine metabolism
salf00250  Alanine, aspartate and glutamate metabolism
salf00270  Cysteine and methionine metabolism
salf00290  Valine, leucine and isoleucine biosynthesis
salf00300  Lysine biosynthesis
salf00330  Arginine and proline metabolism
salf00460  Cyanoamino acid metabolism
salf00470  D-Amino acid metabolism
salf00564  Glycerophospholipid metabolism
salf00600  Sphingolipid metabolism
salf00620  Pyruvate metabolism
salf00630  Glyoxylate and dicarboxylate metabolism
salf00640  Propanoate metabolism
salf00680  Methane metabolism
salf00860  Porphyrin metabolism
salf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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