KEGG   PATHWAY: sbq05207
Entry
sbq05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
sbq05207  Chemical carcinogenesis - receptor activation
sbq05207

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101050618  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101037722  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101046584  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101051959  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101038309  RB1; retinoblastoma-associated protein [KO:K06618]
101029045  E2F1; transcription factor E2F1 [KO:K17454]
101046847  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
101031174  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101031148  CDC6; cell division control protein 6 homolog [KO:K02213]
101041208  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
101049662  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
101027871  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
101050772  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 isoform X1 [KO:K04806]
101031109  CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
101033462  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
101033144  CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
101040048  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101043152  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101034685  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101042219  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101049976  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101046396  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101047083  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101035787  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101035406  RELA; transcription factor p65 [KO:K04735]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101047035  KRAS; GTPase KRas isoform X1 [KO:K07827]
101036877  NRAS; GTPase NRas [KO:K07828]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101046701  FOS; proto-oncogene c-Fos [KO:K04379]
101043809  JUN; transcription factor AP-1 [KO:K04448]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
101051366  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101046010  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101039384  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101032613  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101032691  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101030554  FGF2; fibroblast growth factor 2 [KO:K18497]
101034868  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
101029188  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
101043452  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104652116  neuroendocrine secretory protein 55 [KO:K04632]
101027981  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101043334  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101040601  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101044688  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101049747  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101037803  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101032672  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101034552  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
101052034  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101034085  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101035834  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101034435  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101042795  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101044974  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101036473  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101052885  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101041199  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4 [KO:K09048]
101054090  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101047355  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101042629  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101041681  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101032105  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101049631  BAD; bcl2-associated agonist of cell death [KO:K02158]
101054032  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
101045905  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101047213  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101045276  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
101035085  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
101034130  estrogen receptor [KO:K08550]
101046392  ESR2; estrogen receptor beta [KO:K08551]
101042864  VDR; vitamin D3 receptor isoform X1 [KO:K08539]
101047749  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101038666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101036943  SOS1; son of sevenless homolog 1 [KO:K03099]
101046427  SOS2; son of sevenless homolog 2 [KO:K03099]
101030055  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
101029508  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101033758  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101038541  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101028417  PAQR7; membrane progestin receptor alpha [KO:K25039]
101036800  PAQR8; membrane progestin receptor beta [KO:K25040]
101033792  PAQR5; membrane progestin receptor gamma [KO:K25041]
101046070  PGR; progesterone receptor [KO:K08556]
101051208  TNFSF11; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 11 [KO:K05473]
101049987  signal transducer and activator of transcription 5A [KO:K11223]
101043203  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101034308  BCL6; B-cell lymphoma 6 protein [KO:K15618]
101029684  KLF5; Krueppel-like factor 5 [KO:K09206]
101041940  KLF4; Krueppel-like factor 4 [KO:K17846]
101044133  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101041963  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
101043243  JAG1; protein jagged-1 isoform X1 [KO:K06052]
101052478  EGF; pro-epidermal growth factor [KO:K04357]
101048161  FGF8; fibroblast growth factor 8 [KO:K04358]
101040388  FGF20; fibroblast growth factor 20 [KO:K04358]
101040926  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
101047221  FGF4; fibroblast growth factor 4 [KO:K04358]
101046667  FGF18; fibroblast growth factor 18 [KO:K04358]
101046606  FGF10; fibroblast growth factor 10 [KO:K04358]
101042449  FGF3; fibroblast growth factor 3 [KO:K04358]
101048187  FGF6; fibroblast growth factor 6 [KO:K04358]
101052821  FGF9; fibroblast growth factor 9 [KO:K04358]
101031255  FGF7; fibroblast growth factor 7 [KO:K04358]
101050264  FGF16; fibroblast growth factor 16 [KO:K04358]
101031426  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101044427  DLL4; delta-like protein 4 [KO:K06051]
101041321  DLL1; delta-like protein 1 [KO:K06051]
101036391  DLL3; delta-like protein 3 [KO:K06051]
101045432  prostaglandin E synthase 3-like [KO:K15730] [EC:5.3.99.3]
101044839  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
101051406  AIPL1; aryl-hydrocarbon-interacting protein-like 1 isoform X1 [KO:K17767]
101031026  AIP; AH receptor-interacting protein isoform X1 [KO:K17767]
101051546  AHR; aryl hydrocarbon receptor [KO:K09093]
101033641  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101035124  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101039180  heat shock protein HSP 90-beta [KO:K04079]
101051018  heat shock protein 90 homolog [KO:K04079]
101028609  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101038228  HSP90B1; endoplasmin [KO:K09487]
101045131  KPNA1; importin subunit alpha-5 [KO:K23940]
101028800  KPNA2; importin subunit alpha-1 [KO:K15043]
101043308  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
101040318  LOW QUALITY PROTEIN: importin subunit alpha-8-like [KO:K15043]
101042294  KPNA7; importin subunit alpha-8 [KO:K15043]
101049531  LOW QUALITY PROTEIN: importin subunit alpha-8-like [KO:K15043]
101033975  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
101044908  KPNA3; importin subunit alpha-4 [KO:K23583]
101032036  KPNA5; importin subunit alpha-6 [KO:K15042]
101043160  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
101028951  KPNB1; importin subunit beta-1 [KO:K14293]
101038733  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
101038217  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101049264  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
101029266  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
101033420  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101039796  EPHX3; epoxide hydrolase 3 isoform X1 [KO:K22368] [EC:3.3.2.10]
101041132  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
101041476  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
101040943  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
104651131  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
101048510  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101048833  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
101049145  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
101046934  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101042271  MGST3; microsomal glutathione S-transferase 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
101039426  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101047714  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101030375  LOW QUALITY PROTEIN: glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
101034128  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
101034438  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101033808  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101039061  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
101038805  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
101029477  UGT2B17; UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
101029159  UGT2A3; UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
101031899  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101030863  UDP-glucuronosyltransferase 2B7 [KO:K00699] [EC:2.4.1.17]
101031379  UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
101032959  UDP-glucuronosyltransferase 2B19 [KO:K00699] [EC:2.4.1.17]
101032210  UDP-glucuronosyltransferase 2A1 isoform X3 [KO:K00699] [EC:2.4.1.17]
101048569  UDP-glucuronosyltransferase 1-1 isoform X1 [KO:K00699] [EC:2.4.1.17]
101048262  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
104652750  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
104652745  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
101047616  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
101047290  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-10 [KO:K00699] [EC:2.4.1.17]
101041829  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
101049831  NR1I3; nuclear receptor subfamily 1 group I member 3 isoform X2 [KO:K08541]
101044148  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
101040304  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101040247  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101037403  cytochrome P450 3A21 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
101037899  cytochrome P450 1A2 isoform X1 [KO:K07409] [EC:1.14.14.1]
101032215  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
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Reference
PMID:19631282
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Mutat Res 682:94-109 (2009)
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Reference
PMID:21444681
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Wu CH, Lee CH, Ho YS
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Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
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Clin Cancer Res 17:3533-41 (2011)
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Reference
PMID:19194381
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  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
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Nat Rev Cancer 9:195-205 (2009)
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Reference
PMID:21541211
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Singh S, Pillai S, Chellappan S
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Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
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J Oncol 2011:456743 (2011)
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Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
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J Cancer 11:1125-1140 (2020)
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Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
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Mol Cancer Res 12:14-23 (2014)
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Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
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Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
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Trends Pharmacol Sci 29:151-8 (2008)
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Reference
PMID:24830349
  Authors
Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
  Journal
Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:28664511
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
PMID:22330135
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Related
pathway
sbq00980  Metabolism of xenobiotics by cytochrome P450
sbq03320  PPAR signaling pathway
sbq04010  MAPK signaling pathway
sbq04024  cAMP signaling pathway
sbq04150  mTOR signaling pathway
sbq04151  PI3K-Akt signaling pathway
sbq04370  VEGF signaling pathway
sbq04915  Estrogen signaling pathway
sbq05204  Chemical carcinogenesis - DNA adducts
sbq05206  MicroRNAs in cancer
sbq05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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