KEGG   PATHWAY: sed00260
Entry
sed00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Dublin
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sed00260  Glycine, serine and threonine metabolism
sed00260

Module
sed_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sed00260]
sed_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sed00260]
sed_M00621  Glycine cleavage system [PATH:sed00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Dublin [GN:sed]
Gene
SeD_A4614  lysC; aspartokinase III, lysine-sensitive [KO:K00928] [EC:2.7.2.4]
SeD_A0002  thrA; aspartokinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
SeD_A4502  metL; aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
SeD_A3909  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SeD_A0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
SeD_A0004  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SeD_A1001  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SeD_A4508  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SeD_A2930  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SeD_A2239  putative 2-hydroxyacid dehydrogenase YcdW [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SeD_A4029  2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SeD_A3279  glycerate kinase 2 [KO:K00865] [EC:2.7.1.165]
SeD_A2858  glycerate kinase [KO:K00865] [EC:2.7.1.165]
SeD_A0573  glycerate kinase 1 [KO:K00865] [EC:2.7.1.165]
SeD_A0867  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SeD_A4997  phosphoglycerate mutase family protein [KO:K15634] [EC:5.4.2.11]
SeD_A4090  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SeD_A3402  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SeD_A1041  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SeD_A4990  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
SeD_A1826  NADP-dependent l-serine/l-allo-threonine dehydrogenase ydfg [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SeD_A4095  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SeD_A4094  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SeD_A3390  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SeD_A3392  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
SeD_A0167  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SeD_A3391  gcvH; glycine cleavage system H protein [KO:K02437]
SeD_A2980  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
SeD_A3294  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SeD_A2545  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SeD_A1490  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SeD_A3598  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SeD_A4295  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
SeD_A3602  tdcB; threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
SeD_A4190  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
SeD_A3347  aspartate racemase [KO:K25316] [EC:5.1.1.10]
SeD_A1601  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
SeD_A1602  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sed00010  Glycolysis / Gluconeogenesis
sed00020  Citrate cycle (TCA cycle)
sed00230  Purine metabolism
sed00250  Alanine, aspartate and glutamate metabolism
sed00270  Cysteine and methionine metabolism
sed00290  Valine, leucine and isoleucine biosynthesis
sed00300  Lysine biosynthesis
sed00330  Arginine and proline metabolism
sed00460  Cyanoamino acid metabolism
sed00470  D-Amino acid metabolism
sed00564  Glycerophospholipid metabolism
sed00600  Sphingolipid metabolism
sed00620  Pyruvate metabolism
sed00630  Glyoxylate and dicarboxylate metabolism
sed00640  Propanoate metabolism
sed00680  Methane metabolism
sed00860  Porphyrin metabolism
sed00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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