KEGG   PATHWAY: sej00260
Entry
sej00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Typhimurium UK-1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sej00260  Glycine, serine and threonine metabolism
sej00260

Module
sej_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sej00260]
sej_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sej00260]
sej_M00621  Glycine cleavage system [PATH:sej00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Typhimurium UK-1 [GN:sej]
Gene
STMUK_4205  lysC; aspartate kinase III [KO:K00928] [EC:2.7.2.4]
STMUK_0002  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
STMUK_4086  metM; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
STMUK_3524  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
STMUK_0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
STMUK_0004  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
STMUK_0902  ltaA; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
STMUK_2587  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
STMUK_1103  ycdW; putative oxidoreductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
STMUK_3633  yiaE; 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
STMUK_0532  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
STMUK_2948  putative glycerate kinase 2 [KO:K00865] [EC:2.7.1.165]
STMUK_3235  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
STMUK_0777  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
STMUK_4572  gpmB; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
STMUK_3690  pmgI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
STMUK_3050  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
STMUK_0943  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
STMUK_4565  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
STMUK_1475  ydfG; 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
STMUK_3695  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
STMUK_3694  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
STMUK_3041  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
STMUK_3043  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
STMUK_0156  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
STMUK_3042  gcvH; glycine cleavage system protein H [KO:K02437]
STMUK_2688  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
STMUK_2959  sdaB; L-serine dehydratase/L-threonine deaminase 2 [KO:K01752] [EC:4.3.1.17]
STMUK_3229  tdcG; L-serine deaminase [KO:K01752] [EC:4.3.1.17]
STMUK_1799  sdaA; L-serine deaminase I/L-threonine deaminase I [KO:K01752] [EC:4.3.1.17]
STMUK_2226  putative L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
STMUK_3233  tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STMUK_3892  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STMUK_3790  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
STMUK_3003  ygeA; putative racemase [KO:K25316] [EC:5.1.1.10]
STMUK_1699  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
STMUK_1698  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sej00010  Glycolysis / Gluconeogenesis
sej00020  Citrate cycle (TCA cycle)
sej00230  Purine metabolism
sej00250  Alanine, aspartate and glutamate metabolism
sej00270  Cysteine and methionine metabolism
sej00290  Valine, leucine and isoleucine biosynthesis
sej00300  Lysine biosynthesis
sej00330  Arginine and proline metabolism
sej00460  Cyanoamino acid metabolism
sej00470  D-Amino acid metabolism
sej00564  Glycerophospholipid metabolism
sej00600  Sphingolipid metabolism
sej00620  Pyruvate metabolism
sej00630  Glyoxylate and dicarboxylate metabolism
sej00640  Propanoate metabolism
sej00680  Methane metabolism
sej00860  Porphyrin metabolism
sej00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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