Entry
Name
ABC transporters - Salmonella enterica subsp. enterica serovar Typhimurium 14028S
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Salmonella enterica subsp. enterica serovar Typhimurium 14028S [GN:
seo ]
Gene
STM14_0904 modF; putative molybdenum transport ATP-binding protein ModF [KO:K05776 ]
STM14_1397 potD; spermidine/putrescine ABC transporter periplasmic substrate-binding protein [KO:K11069 ]
STM14_1398 potC; spermidine/putrescine ABC transporter membrane protein [KO:K11070 ]
STM14_1402 potB; spermidine/putrescine ABC transporter membrane protein [KO:K11071 ]
STM14_1028 potF; putrescine ABC transporter periplasmic substrate-binding protein [KO:K11073 ]
STM14_2666 yehW; putative ABC-type proline/glycine betaine transport system permease component [KO:K05846 ]
STM14_2668 yehY; putative ABC-type proline/glycine betaine transport system permease component [KO:K05846 ]
STM14_2667 yehX; putative ABC-type proline/glycine betaine transport system ATPase component [KO:K05847 ] [EC:7.6.2.9 ]
STM14_5086 malK; maltose/maltodextrin transporter ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
STM14_2695 mglC; beta-methylgalactoside transporter inner membrane component [KO:K10541 ]
STM14_4283 ugpB; glycerol-3-phosphate transporter periplasmic binding protein [KO:K05813 ]
STM14_2898 hisM; histidine/lysine/arginine/ornithine transport protein [KO:K10015 ]
STM14_2899 hisQ; histidine/lysine/arginine/ornithine transport protein [KO:K10016 ]
STM14_2370 yecS; putative ABC-type amino acid transporter permease component [KO:K10009 ]
STM14_4290 livK; high-affinity branched-chain amino acid transporter [KO:K01999 ]
STM14_4294 livJ; high-affinity branched-chain amino acid transporter [KO:K01999 ]
STM14_4289 livH; branched-chain amino acid transporter permease subunit LivH [KO:K01997 ]
STM14_4288 livM; leucine/isoleucine/valine transporter permease subunit [KO:K01998 ]
STM14_4287 livG; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995 ]
STM14_4286 livF; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01996 ]
STM14_0600 sfbA; putative ABC-type transport system ATPase component [KO:K02073 ]
STM14_0287 metQ; DL-methionine transporter substrate-binding subunit [KO:K02073 ]
STM14_0601 sfbB; putative ABC-type transport system ATPase component [KO:K02071 ]
STM14_992 yliB; putative ABC transporter periplasmic binding protein [KO:K13889 ]
STM14_993 yliC; putative ABC transporter periplasmic binding protein [KO:K13890 ]
STM14_994 yliD; putative ABC transporter inner membrane component [KO:K13891 ]
STM14_2740 yejA; putative ABC transporter periplasmic binding protein [KO:K13893 ]
STM14_2741 yejB; putative ABC-type dipeptide/oligopeptide/nickel transport system permease [KO:K13894 ]
STM14_2742 yejE; putative ABC-type dipeptide/oligopeptide/nickel transport system permease component [KO:K13895 ]
STM14_2743 yejF; putative ABC-type transport system ATPase component [KO:K13896 ]
STM14_0692 fepB; iron-enterobactin transporter periplasmic binding protein [KO:K23185 ]
STM14_0230 fhuD; iron-hydroxamate transporter substrate-binding subunit [KO:K23227 ]
STM14_2300 znuA; high-affinity zinc transporter periplasmic component [KO:K09815 ]
STM14_3714 putative ABC-type cobalt transport system permease component [KO:K16785 ]
STM14_3715 putative ABC-type cobalt transport system ATP-binding component [KO:K16786 ] [EC:7.-.-.-]
STM14_3716 putative ABC-type cobalt transport system ATP-binding component [KO:K16787 ] [EC:7.-.-.-]
STM14_4899 ego; putative ABC-type aldose transport system ATPase component [KO:K10558 ]
STM14_0842 putative ABC-type polysaccharide/polyol phosphate transport system ATPase component [KO:K09691 ] [EC:7.5.2.14 ]
STM14_1392 ycfU; outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808 ]
STM14_1394 ycfW; outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808 ]
STM14_1393 lolD; lipoprotein transporter ATP-binding subunit [KO:K09810 ] [EC:7.6.2.-]
STM14_0544 mdlA; putative multidrug transporter membrane\ATP-binding component [KO:K18889 ]
STM14_0545 mdlB; putative multidrug transporter membrane\ATP-binding component [KO:K18890 ]
STM14_1078 cydC; cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16012 ]
STM14_1079 cydD; cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16013 ]
STM14_1059 ybjZ; macrolide transporter ATP-binding/permease protein [KO:K05685 ] [EC:7.6.2.-]
STM14_2793 yojI; multidrug transporter membrane component/ATP-binding component [KO:K06159 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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