KEGG   PATHWAY: sgh04916
Entry
sgh04916                    Pathway                                
Name
Melanogenesis - Sinocyclocheilus grahami (golden-line barbel)
Description
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.
Class
Organismal Systems; Endocrine system
Pathway map
sgh04916  Melanogenesis
sgh04916

Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107592776  pro-opiomelanocortin-1 [KO:K05228]
107594781  pro-opiomelanocortin-2-like [KO:K05228]
107603097  pro-opiomelanocortin B-like [KO:K05228]
107549702  pro-opiomelanocortin B-like [KO:K05228]
107596783  agouti-signaling protein-like [KO:K08725]
107554169  agouti-signaling protein-like [KO:K08725]
107550117  mc1r; melanocyte-stimulating hormone receptor [KO:K04199]
107596786  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
107554191  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
107568325  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107568330  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107559745  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107563079  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107581454  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107595616  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
107551198  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
107584338  adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107598935  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
107593287  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
107572836  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
107555914  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
107596066  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
107568450  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107601336  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107594095  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107571464  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107551487  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
107554606  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
107569488  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107549698  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107594777  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107603098  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
107592799  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
107557810  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107566051  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
107553626  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
107601541  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
107566672  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
107562862  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107600310  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107602709  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
107560415  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107592581  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107599301  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107573599  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107594309  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107598164  cyclic AMP-responsive element-binding protein 1 [KO:K05870]
107551947  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
107552236  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
107598781  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
107580477  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
107599998  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
107596868  cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
107558280  cyclic AMP-responsive element-binding protein 3-like protein 3-A isoform X1 [KO:K09048]
107570797  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
107583953  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
107573899  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
107579521  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
107586456  cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
107554591  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
107560116  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
107602824  uncharacterized protein LOC107602824 [KO:K09048]
107566050  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107602282  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107553628  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107554018  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107566670  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107584175  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107583302  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107601576  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107558920  microphthalmia-associated transcription factor-like [KO:K09455]
107599418  microphthalmia-associated transcription factor-like [KO:K09455]
107584515  microphthalmia-associated transcription factor-like [KO:K09455]
107554224  microphthalmia-associated transcription factor-like [KO:K09455]
107570486  protein Wnt-1-like [KO:K03209]
107563635  protein Wnt-1 [KO:K03209]
107549309  protein Wnt-2b-like [KO:K00182]
107562779  protein Wnt-2b-A [KO:K00182]
107569802  protein Wnt-2b-A-like [KO:K00182]
107583858  protein Wnt-2-like [KO:K00182]
107596948  protein Wnt-2 [KO:K00182]
107593875  wnt3a; protein Wnt-3a [KO:K00312]
107556586  proto-oncogene Wnt-3-like [KO:K00312]
107584390  proto-oncogene Wnt-3 [KO:K00312]
107558010  protein Wnt-3a-like [KO:K00312]
107552850  protein Wnt-4-like [KO:K00408]
107565731  protein Wnt-4a [KO:K00408]
107582399  protein Wnt-4a-like [KO:K00408]
107587793  protein Wnt-4-like [KO:K00408]
107572035  protein Wnt-5b-like [KO:K00444]
107553896  protein Wnt-5a-like [KO:K00444]
107580320  protein Wnt-5b [KO:K00444]
107566314  protein Wnt-6-like [KO:K00445]
107560470  protein Wnt-6-like [KO:K00445]
107562106  protein Wnt-6-like [KO:K00445]
107566782  protein Wnt-6-like [KO:K00445]
107549584  protein Wnt-7b-like [KO:K00572]
107553875  wnt7b; protein Wnt-7b [KO:K00572]
107591249  protein Wnt-7b-like isoform X1 [KO:K00572]
107564804  protein Wnt-7a-like [KO:K00572]
107556172  protein Wnt-7a-like [KO:K00572]
107581407  protein Wnt-7a-like [KO:K00572]
107558594  protein Wnt-7b isoform X1 [KO:K00572]
107555800  protein Wnt-7a-like [KO:K00572]
107568687  protein Wnt-8a-like isoform X1 [KO:K00714]
107568688  protein Wnt-8a-like [KO:K00714]
107602558  protein Wnt-8a [KO:K00714]
107602559  protein Wnt-8a-like [KO:K00714]
107585301  protein Wnt-8b-like [KO:K00714]
107588635  protein Wnt-8b [KO:K00714]
107590369  protein Wnt-9b-like [KO:K01064]
107601233  protein Wnt-9b-like [KO:K01064]
107593876  wnt9a; protein Wnt-9a [KO:K01064]
107558013  protein Wnt-9a-like [KO:K01064]
107560469  protein Wnt-10a [KO:K01357]
107570475  protein Wnt-10b-like [KO:K01357]
107562105  protein Wnt-10a-like [KO:K01357]
107563634  protein Wnt-10b [KO:K01357]
107548453  protein Wnt-11 [KO:K01384]
107577355  protein Wnt-11-like [KO:K01384]
107589704  protein Wnt-11-like isoform X1 [KO:K01384]
107596154  protein Wnt-11-like [KO:K01384]
107565671  protein Wnt-16-like [KO:K01558]
107592255  protein Wnt-16-like [KO:K01558]
107584796  frizzled-7-A-like [KO:K02432]
107601959  frizzled-1-like [KO:K02432]
107596530  fzd7; frizzled-7 [KO:K02432]
107581350  frizzled-7-A-like [KO:K02432]
107565291  frizzled-1-like [KO:K02432]
107593015  frizzled-7-A-like [KO:K02432]
107564008  frizzled-2-like [KO:K02235]
107583044  frizzled-2-like [KO:K02235]
107599066  frizzled-3-like isoform X1 [KO:K02329]
107553488  frizzled-3-like isoform X1 [KO:K02329]
107589599  frizzled-3-like isoform X1 [KO:K02329]
107586633  frizzled-3-like [KO:K02329]
107551868  frizzled-4-like [KO:K02354]
107600811  frizzled-4-like [KO:K02354]
107588041  frizzled-8-like [KO:K02375]
107572999  frizzled-8-like [KO:K02375]
107598163  frizzled-5-like [KO:K02375]
107551950  frizzled-5-like [KO:K02375]
107557558  frizzled-8-like [KO:K02375]
107594624  fzd6; frizzled-6 [KO:K02376]
107555113  frizzled-10-A-like [KO:K02842]
107557825  frizzled-9-like [KO:K02842]
107557826  frizzled-9-like [KO:K02842]
107574912  frizzled-10-B-like [KO:K02842]
107572577  frizzled-9-like [KO:K02842]
107563503  frizzled-9-like [KO:K02842]
107600608  frizzled-9 [KO:K02842]
107583720  gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
107585963  guanine nucleotide-binding protein G(o) subunit alpha-like [KO:K04534]
107593163  guanine nucleotide-binding protein G(o) subunit alpha-like isoform X1 [KO:K04534]
107596000  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107593323  guanine nucleotide-binding protein subunit alpha-11 [KO:K04634]
107586405  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04634]
107600584  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
107586443  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
107575491  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107570850  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
107602099  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107593841  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107597062  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
107559372  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107586546  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
107595298  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
107560111  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
107551994  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107559500  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
107569048  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
107602383  ctnnb1; catenin beta-1 [KO:K02105]
107564884  catenin beta-1-like [KO:K02105]
107570993  catenin beta-1 isoform X1 [KO:K02105]
107592060  catenin beta-1-like [KO:K02105]
107603263  transcription factor 7-like [KO:K02620]
107557295  transcription factor 7-like 2 isoform X1 [KO:K02620]
107558109  transcription factor 7-like 1-A [KO:K04490]
107563849  transcription factor 7-like 1-B [KO:K04490]
107556226  transcription factor 7-like 1-B [KO:K04490]
107602061  transcription factor 7-like 1-A [KO:K04490]
107581563  transcription factor 7-like 2 [KO:K04491]
107566231  transcription factor 7-like 2 isoform X1 [KO:K04491]
107583218  lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
107594427  lymphoid enhancer-binding factor 1-like [KO:K04492]
107572933  kit ligand-like [KO:K05461]
107580747  uncharacterized protein LOC107580747 isoform X1 [KO:K05461]
107574894  kit ligand-like [KO:K05461]
107591536  mast/stem cell growth factor receptor kita-like [KO:K05091] [EC:2.7.10.1]
107551583  mast/stem cell growth factor receptor Kit-like [KO:K05091] [EC:2.7.10.1]
107597437  mast/stem cell growth factor receptor kita-like isoform X1 [KO:K05091] [EC:2.7.10.1]
107601906  mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
107562835  GTPase HRas-like isoform X1 [KO:K02833]
107558311  GTPase HRas-like [KO:K02833]
107600445  GTPase HRas-like [KO:K02833]
107596435  GTPase HRas isoform X1 [KO:K02833]
107567516  GTPase HRas-like [KO:K07827]
107549277  ras-like protein isoform X1 [KO:K07827]
107560753  GTPase HRas-like [KO:K07827]
107595236  ras-like protein isoform X1 [KO:K07827]
107598969  GTPase NRas-like [KO:K07828]
107566814  GTPase NRas [KO:K07828]
107564278  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107571214  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107555780  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
107583767  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
107596971  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107575785  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107596877  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107552672  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107586388  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107590568  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107599610  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107599134  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107567791  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107558837  tyr; tyrosinase [KO:K00505] [EC:1.14.18.1]
107567374  5,6-dihydroxyindole-2-carboxylic acid oxidase [KO:K00506] [EC:1.14.18.-]
107591533  5,6-dihydroxyindole-2-carboxylic acid oxidase-like [KO:K00506] [EC:1.14.18.-]
107551586  5,6-dihydroxyindole-2-carboxylic acid oxidase-like isoform X1 [KO:K00506] [EC:1.14.18.-]
107567421  L-dopachrome tautomerase-like [KO:K01827] [EC:5.3.3.12]
107558385  dct; L-dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
107551767  endothelin-1-like [KO:K16366]
107559691  endothelin-1-like [KO:K16366]
107566659  endothelin B receptor-like [KO:K04198]
107574150  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
107581736  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
107551795  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
107554950  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
107550494  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
107591822  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
107595419  guanine nucleotide-binding protein G(i) subunit alpha-2-like isoform X1 [KO:K04630]
107587570  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107590838  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107552868  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
107552879  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
107594127  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107557900  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107557901  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
107560167  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
107569311  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
107583283  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
107564330  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
107564333  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107581490  calmodulin [KO:K02183]
107597846  calmodulin-like [KO:K02183]
107548236  calmodulin [KO:K02183]
107582745  calmodulin [KO:K02183]
107582783  calmodulin [KO:K02183]
107593483  calmodulin-like isoform X1 [KO:K02183]
107549625  calmodulin-like protein 4 isoform X1 [KO:K02183]
107559413  calmodulin [KO:K02183]
107561747  calmodulin-A isoform X1 [KO:K02183]
107550044  calmodulin [KO:K02183]
107590878  calmodulin [KO:K02183]
107586481  calmodulin [KO:K02183]
107563455  calmodulin-like protein 4 [KO:K02183]
107553107  calmodulin-like protein 4 [KO:K02183]
107590004  calm2; calmodulin [KO:K02183]
107568545  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107563926  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
107595950  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107601404  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107561852  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107562980  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
107581888  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
107561529  calcium/calmodulin-dependent protein kinase type II delta 1 chain [KO:K04515] [EC:2.7.11.17]
107554545  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
107562154  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
107588949  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107597268  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107601773  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107556610  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
107569462  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107586338  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
107590404  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
107601253  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107564527  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107590741  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
107549470  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
107598407  LOW QUALITY PROTEIN: protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05606  Melanin
Reference
PMID:15383650
  Authors
Slominski A, Tobin DJ, Shibahara S, Wortsman J.
  Title
Melanin pigmentation in mammalian skin and its hormonal regulation.
  Journal
Physiol Rev 84:1155-228 (2004)
DOI:10.1152/physrev.00044.2003
Reference
PMID:10841026
  Authors
Busca R, Ballotti R.
  Title
Cyclic AMP a key messenger in the regulation of skin pigmentation.
  Journal
Pigment Cell Res 13:60-9 (2000)
DOI:10.1034/j.1600-0749.2000.130203.x
Reference
PMID:15016298
  Authors
Imokawa G.
  Title
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders.
  Journal
Pigment Cell Res 17:96-110 (2004)
DOI:10.1111/j.1600-0749.2003.00126.x
Reference
PMID:11023702
  Authors
Wikberg JE, Muceniece R, Mandrika I, Prusis P, Lindblom J, Post C, Skottner A.
  Title
New aspects on the melanocortins and their receptors.
  Journal
Pharmacol Res 42:393-420 (2000)
DOI:10.1006/phrs.2000.0725
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12753399
  Authors
Saito H, Yasumoto K, Takeda K, Takahashi K, Yamamoto H, Shibahara S.
  Title
Microphthalmia-associated transcription factor in the Wnt signaling pathway.
  Journal
Pigment Cell Res 16:261-5 (2003)
DOI:10.1034/j.1600-0749.2003.00039.x
Reference
PMID:9263329
  Authors
Imokawa G, Kobayashi T, Miyagishi M, Higashi K, Yada Y.
  Title
The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis.
  Journal
Pigment Cell Res 10:218-28 (1997)
DOI:10.1111/j.1600-0749.1997.tb00488.x
Reference
PMID:10643996
  Authors
Park HY, Gilchrest BA.
  Title
Signaling pathways mediating melanogenesis.
  Journal
Cell Mol Biol (Noisy-le-grand) 45:919-30 (1999)
Reference
PMID:10347209
  Authors
Park HY, Perez JM, Laursen R, Hara M, Gilchrest BA.
  Title
Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain.
  Journal
J Biol Chem 274:16470-8 (1999)
DOI:10.1074/jbc.274.23.16470
Reference
PMID:11602344
  Authors
Sturm RA, Teasdale RD, Box NF.
  Title
Human pigmentation genes: identification, structure and consequences of polymorphic variation.
  Journal
Gene 277:49-62 (2001)
DOI:10.1016/S0378-1119(01)00694-1
Reference
PMID:11041354
  Authors
Hearing VJ.
  Title
The melanosome: the perfect model for cellular responses to the environment.
  Journal
Pigment Cell Res 13 Suppl 8:23-34 (2000)
DOI:10.1034/j.1600-0749.13.s8.7.x
Reference
PMID:16246839
  Authors
Molina DM, Grewal S, Bardwell L.
  Title
Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation.
  Journal
J Biol Chem 280:42051-60 (2005)
DOI:10.1074/jbc.M510590200
Related
pathway
sgh00350  Tyrosine metabolism
sgh04010  MAPK signaling pathway
sgh04310  Wnt signaling pathway
KO pathway
ko04916   
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