KEGG   PATHWAY: sine00260
Entry
sine00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces inhibens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sine00260  Glycine, serine and threonine metabolism
sine00260

Module
sine_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sine00260]
sine_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sine00260]
sine_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sine00260]
sine_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sine00260]
sine_M00555  Betaine biosynthesis, choline => betaine [PATH:sine00260]
sine_M00621  Glycine cleavage system [PATH:sine00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces inhibens [GN:sine]
Gene
KI385_24745  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KI385_16535  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KI385_24750  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KI385_30405  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KI385_30415  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
KI385_38895  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
KI385_27020  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KI385_30410  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KI385_08815  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KI385_05990  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KI385_28105  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KI385_30455  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KI385_31005  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KI385_35795  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KI385_26775  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
KI385_38815  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KI385_31325  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KI385_37530  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KI385_27355  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
KI385_11640  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
KI385_23500  HAD-IB family phosphatase [KO:K01079] [EC:3.1.3.3]
KI385_35590  SDR family oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KI385_06150  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
KI385_06155  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KI385_38420  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
KI385_38590  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KI385_38600  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KI385_03665  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KI385_34335  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
KI385_07275  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KI385_31015  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KI385_13505  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KI385_34295  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KI385_31010  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KI385_15405  serine/threonine protein kinase [KO:K00613] [EC:2.1.4.1]
KI385_35800  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KI385_05940  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
KI385_36285  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
KI385_05950  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
KI385_27970  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
KI385_31975  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KI385_32010  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KI385_36295  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
KI385_05965  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
KI385_05960  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
KI385_35155  methyltransferase domain-containing protein [KO:K18896] [EC:2.1.1.156]
KI385_18755  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KI385_23525  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
KI385_05995  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KI385_30995  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KI385_28685  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
KI385_02005  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
KI385_12765  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KI385_12770  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KI385_04770  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
KI385_11960  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
KI385_32685  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
KI385_11955  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
KI385_11965  ectoine synthase [KO:K06720] [EC:4.2.1.108]
KI385_11970  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
KI385_11500  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
KI385_12610  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sine00010  Glycolysis / Gluconeogenesis
sine00020  Citrate cycle (TCA cycle)
sine00230  Purine metabolism
sine00250  Alanine, aspartate and glutamate metabolism
sine00270  Cysteine and methionine metabolism
sine00290  Valine, leucine and isoleucine biosynthesis
sine00300  Lysine biosynthesis
sine00330  Arginine and proline metabolism
sine00460  Cyanoamino acid metabolism
sine00470  D-Amino acid metabolism
sine00564  Glycerophospholipid metabolism
sine00600  Sphingolipid metabolism
sine00620  Pyruvate metabolism
sine00630  Glyoxylate and dicarboxylate metabolism
sine00640  Propanoate metabolism
sine00680  Methane metabolism
sine00860  Porphyrin metabolism
sine00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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