KEGG   PATHWAY: slb04148
Entry
slb04148                    Pathway                                
Name
Efferocytosis - Sugiyamaella lignohabitans
Class
Cellular Processes; Transport and catabolism
Pathway map
slb04148  Efferocytosis
slb04148

Organism
Sugiyamaella lignohabitans [GN:slb]
Gene
AWJ20_3638  LCB4; sphinganine kinase LCB4 [KO:K04718] [EC:2.7.1.91]
AWJ20_4514  FUS3; mitogen-activated serine/threonine-protein kinase FUS3 [KO:K04371] [EC:2.7.11.24]
AWJ20_3640  HOG1; mitogen-activated protein kinase HOG1 [KO:K04441] [EC:2.7.11.24]
AWJ20_3173  PPS1; tyrosine/serine/threonine protein phosphatase PPS1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
AWJ20_4638  DRS2; aminophospholipid-translocating P4-type ATPase DRS2 [KO:K14802] [EC:7.6.2.1]
AWJ20_4639  DRS2; aminophospholipid-translocating P4-type ATPase DRS2 [KO:K14802] [EC:7.6.2.1]
AWJ20_2169  CDC50; aminophospholipid translocase regulatory protein CDC50 [KO:K26935]
AWJ20_2632  CDC42; Rho family GTPase CDC42 [KO:K04392]
AWJ20_2261  VPS21; Rab family GTPase VPS21 [KO:K07889]
AWJ20_4877  VPS21; Rab family GTPase VPS21 [KO:K07889]
AWJ20_3820  VPS3; CORVET complex subunit VPS3 [KO:K20177]
AWJ20_509  VPS8; CORVET complex membrane-binding subunit VPS8 [KO:K20178]
AWJ20_3972  PEP5; tethering complex subunit PEP5 [KO:K20179]
AWJ20_2996  VPS16; tethering complex subunit VPS16 [KO:K20180]
AWJ20_2989  PEP3; tethering complex subunit PEP3 [KO:K20181]
AWJ20_1338  VPS33; tethering complex ATP-binding subunit VPS33 [KO:K20182]
AWJ20_851  VAM6; Vam6p [KO:K20183]
AWJ20_3650  VPS41; Vps41p [KO:K20184]
AWJ20_3779  YPT7; Rab family GTPase YPT7 [KO:K07897]
AWJ20_2074  RTC2; Rtc2p [KO:K23678]
AWJ20_4295  YPQ2; Ypq2p [KO:K23678]
AWJ20_5310  YPQ2; Ypq2p [KO:K23678]
AWJ20_4675  CAR1; arginase [KO:K01476] [EC:3.5.3.1]
AWJ20_1387  SPE1; ornithine decarboxylase SPE1 [KO:K01581] [EC:4.1.1.17]
AWJ20_3707  RIP1; ubiquinol--cytochrome-c reductase catalytic subunit RIP1 [KO:K00411] [EC:7.1.1.8]
AWJ20_1457  TGL1; Tgl1p [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
slb00010  Glycolysis / Gluconeogenesis
slb04145  Phagosome
KO pathway
ko04148   
LinkDB

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