KEGG   PATHWAY: slv02010
Entry
slv02010                    Pathway                                
Name
ABC transporters - Streptomyces lividans
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
slv02010  ABC transporters
slv02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Streptomyces lividans [GN:slv]
Gene
SLIV_01580  Putative binding protein [KO:K15553]
SLIV_07660  lipoprotein [KO:K15553]
SLIV_01590  putative ABC transporter permease protein [KO:K15554]
SLIV_07670  transport system integral membrane protein [KO:K15554]
SLIV_01585  Putative ATP-binding protein [KO:K15555] [EC:7.6.2.14]
SLIV_07665  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
SLIV_19775  substrate-binding transporter [KO:K02020]
SLIV_19770  ABC transporter membrane subunit [KO:K02018]
SLIV_19765  ABC transporter ATP-binding subunit [KO:K02017] [EC:7.3.2.5]
SLIV_08985  hypothetical protein [KO:K02011]
SLIV_08990  putative ATP-binding protein [KO:K02010] [EC:7.2.2.7]
SLIV_10395  solute binding lipoprotein [KO:K02064]
SLIV_10390  ABC transporter integral membrane protein [KO:K02063]
SLIV_10385  fbpC; Fe(3+) ions import ATP-binding protein FbpC [KO:K02062] [EC:7.6.2.15]
SLIV_10290  ABC-transporter polyamine-binding lipoprotein [KO:K11069]
SLIV_10335  polyamine-binding lipoprotein [KO:K11069]
SLIV_10275  polyamine ABC-transporter integral memb rane protein [KO:K11070]
SLIV_10280  polyamine ABC-transporter integral memb rane protein [KO:K11071]
SLIV_10285  potA; Spermidine/putrescine import ATP-binding protein PotA [KO:K11072] [EC:7.6.2.11]
SLIV_14210  glycine betaine-binding lipoprotein [KO:K02002]
SLIV_29640  glycine betaine transport system permease [KO:K02001 K02002]
SLIV_14215  glycine betaine ABC transport system integral membrane protein [KO:K02001]
SLIV_29635  glycine/betaine transport ATP-binding protein [KO:K02000] [EC:7.6.2.9]
SLIV_14220  glycine betaine ABC transport system ATP-binding protein [KO:K02000] [EC:7.6.2.9]
SLIV_23030  permease binding-protein component [KO:K05845]
SLIV_07815  substrate-binding protein [KO:K05845]
SLIV_23035  permease membrane protein [KO:K05846]
SLIV_23045  permease membrane protein [KO:K05846]
SLIV_07820  ABC transporter permease [KO:K05846]
SLIV_07825  ABC transporter permease [KO:K05846]
SLIV_23040  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
SLIV_07830  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
SLIV_29205  ABC sugar transporter, ATP-binding subunit [KO:K10112] [EC:7.5.2.-]
SLIV_17190  sugC; Trehalose import ATP-binding protein SugC [KO:K10112] [EC:7.5.2.-]
SLIV_26565  maltose-binding protein [KO:K15770]
SLIV_26570  maltose permease [KO:K15771]
SLIV_26575  maltose permease [KO:K15772]
SLIV_36465  solute-binding protein [KO:K10117]
SLIV_03440  sugar-binding protein [KO:K10117]
SLIV_36175  solute-binding protein [KO:K10117]
SLIV_06985  sugar transport system sugar-binding lipoprotein [KO:K10117]
SLIV_36460  binding protein dependent transporter [KO:K10118]
SLIV_03445  sugar-transporter integral membrane protein [KO:K10118]
SLIV_36170  binding protein dependent transporter [KO:K10118]
SLIV_06990  sugar transport system permease [KO:K10118]
SLIV_36165  binding-protein-dependent transporter [KO:K10119]
SLIV_36455  sugar ABC-transporter integral membrane protein [KO:K10119]
SLIV_03450  sugar-binding integral membrane transport protein [KO:K10119]
SLIV_06995  sugar transport system permease [KO:K10119]
SLIV_32470  sugar transport sugar binding protein [KO:K10188]
SLIV_32475  sugar transport integral membrane protein [KO:K10189]
SLIV_32480  sugar transport integral membrane protein [KO:K10190]
SLIV_28225  substrate binding protein [KO:K10227]
SLIV_28220  integral membrane sugar transport protein [KO:K10228]
SLIV_28215  integral membrane sugar transporter [KO:K10229]
SLIV_30440  secreted protein [KO:K10232]
SLIV_22810  hypothetical protein [KO:K10232]
SLIV_22805  integral membrane transport protein [KO:K10233]
SLIV_22800  integral membrane transport protein [KO:K10234]
SLIV_10195  lipoprotein [KO:K17318]
SLIV_10190  transport system integral membrane protein [KO:K17319]
SLIV_10185  transport system integral membrane protein [KO:K17320]
SLIV_08110  lipoprotein [KO:K10200]
SLIV_08105  transmembrane transporter [KO:K10201]
SLIV_08100  transmembrane transporter [KO:K10202]
SLIV_23695  sugar binding secreted protein [KO:K10240]
SLIV_01535  solute binding lipoprotein [KO:K10240]
SLIV_23690  cellobiose transport permease [KO:K10241]
SLIV_01530  sugar transport permease [KO:K10241]
SLIV_23685  cellobiose transport permease [KO:K10242]
SLIV_01525  sugar transport integral membrane protein [KO:K10242]
SLIV_35290  sugar transporter sugar binding protein [KO:K17329]
SLIV_33360  lipoprotein [KO:K17329]
SLIV_12205  sugar transporter sugar binding protein [KO:K17329]
SLIV_22965  sugar transporter sugar-binding protein [KO:K17329]
SLIV_35285  sugar transporter membrane protein [KO:K17330]
SLIV_12200  sugar transporter integral membrane protein [KO:K17330]
SLIV_22970  sugar transporter membrane protein [KO:K17330]
SLIV_35280  sugar transporter membrane protein [KO:K17331]
SLIV_12195  sugar transporter integral membrane protein [KO:K17331]
SLIV_22975  sugar transporter membrane protein [KO:K17331]
SLIV_33175  solute-binding protein [KO:K17244]
SLIV_33180  transport system permease [KO:K17245]
SLIV_33185  transport system permease [KO:K17246]
SLIV_04105  sugar-binding lipoprotein [KO:K17326]
SLIV_04100  binding-protein-dependent transport protein [KO:K17327]
SLIV_04095  binding-protein-dependent transport protein [KO:K17328]
SLIV_25680  chvE; Multiple sugar-binding periplasmic receptor ChvE [KO:K10546]
SLIV_25670  sugar transport permease [KO:K10547]
SLIV_25675  araG; L-arabinose transport ATP-binding protein AraG [KO:K10548] [EC:7.5.2.-]
SLIV_25610  hypothetical protein [KO:K02067]
SLIV_25615  secreted protein [KO:K02067]
SLIV_25625  secreted protein [KO:K02067]
SLIV_25630  secreted protein [KO:K02067]
SLIV_25605  hypothetical protein [KO:K02067]
SLIV_25620  hypothetical protein [KO:K02067]
SLIV_25595  ABC-transporter integral membrane protein [KO:K02066]
SLIV_25600  ABC-transporter integral membrane protein [KO:K02066]
SLIV_25590  mkl; putative ribonucleotide transport ATP-binding protein mkl [KO:K02065]
SLIV_13950  lipoprotein [KO:K07335]
SLIV_13955  lipoprotein [KO:K07335]
SLIV_13940  sugar ABC transporter integral membrane protein [KO:K23535]
SLIV_13935  sugar ABC transporter integral membrane protein [KO:K23536]
SLIV_13945  putative ABC transporter ATP-binding protein [KO:K23537]
SLIV_05580  solute binding protein [KO:K10439]
SLIV_23935  bifunctional carbohydrate binding and transport protein [KO:K10439 K10440]
SLIV_05585  ABC transporter [KO:K10440]
SLIV_23940  rbsA; Ribose import ATP-binding protein [KO:K10441] [EC:7.5.2.7]
SLIV_05590  ABC-type transporter, ATP-binding protein [KO:K10441] [EC:7.5.2.7]
SLIV_23925  rbsD; D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
SLIV_19965  solute-binding protein [KO:K10543]
SLIV_08090  solute-binding protein [KO:K10543]
SLIV_08080  ABC transporter [KO:K10544]
SLIV_08085  ABC transporter ATP-binding protein [KO:K10545] [EC:7.5.2.10]
SLIV_33890  solute-binding lipoprotein [KO:K10559]
SLIV_35700  rhamnose ABC transporter, rhamnose-binding protein [KO:K10559]
SLIV_33880  ABC transporter permease [KO:K10560]
SLIV_33885  ABC transporter permease [KO:K10561]
SLIV_33875  ABC transporter ATP-binding protein [KO:K10562] [EC:7.5.2.-]
SLIV_17670  phosphate-binding protein [KO:K02040]
SLIV_25560  phosphate binding protein [KO:K02040]
SLIV_17675  pstC2; Phosphate transport system permease protein PstC 2 [KO:K02037]
SLIV_17680  phosphate ABC transporter permease [KO:K02038]
SLIV_17685  pstB; Phosphate import ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
SLIV_09735  glutamate binding protein [KO:K10005]
SLIV_09740  gluC; Glutamate transport system permease protein GluC [KO:K10006]
SLIV_09745  glutamate permease [KO:K10007]
SLIV_09730  gluA; Glutamate transport ATP-binding protein GluA [KO:K10008] [EC:7.4.2.1]
SLIV_27675  branched chain amino acid binding protein [KO:K01999]
SLIV_03360  branched amino acid binding secreted protein [KO:K01999]
SLIV_16425  lipoprotein [KO:K01999]
SLIV_34395  branched-chain amino acid ABC transporter [KO:K01997]
SLIV_27670  High-affinity branched-chain amino acid transport system permease protein BraD [KO:K01997]
SLIV_03370  branched amino acid transport system permease [KO:K01997]
SLIV_34400  branched-chain amino acid ABC transport permease [KO:K01998]
SLIV_27665  branched chain amino acid transport permease [KO:K01998]
SLIV_03365  branched amino acid transport system permease [KO:K01998]
SLIV_34390  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
SLIV_27660  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
SLIV_03380  branched amino acid transport system ATP-binding protein [KO:K01995]
SLIV_34385  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
SLIV_27655  High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
SLIV_03375  High-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
SLIV_29940  lipoprotein [KO:K02073]
SLIV_29935  ABC transporter permease [KO:K02072]
SLIV_29930  metN; Methionine import ATP-binding protein MetN [KO:K02071]
SLIV_12795  peptide transport system peptide-binding protein [KO:K15580]
SLIV_12790  peptide transport system integral membrane protein [KO:K15581]
SLIV_12785  peptide transport system integral membrane protein [KO:K15582]
SLIV_12780  appD; Oligopeptide transport ATP-binding protein AppD [KO:K15583]
SLIV_12775  appF; Oligopeptide transport ATP-binding protein AppF [KO:K10823]
SLIV_23775  hypothetical protein [KO:K25287]
SLIV_35470  iron-siderophore binding lipoprotein [KO:K25286]
SLIV_28800  iron-siderophore uptake system transmembrane component [KO:K23186]
SLIV_35455  iron-siderophore permease transmembrane protein [KO:K23186]
SLIV_28805  iron-siderophore uptake system transmembrane protein [KO:K23187]
SLIV_35460  iron-siderophore permease transmembrane protein [KO:K23187]
SLIV_28810  fepC; Ferric enterobactin transport ATP-binding protein FepC [KO:K23188] [EC:7.2.2.17 7.2.2.-]
SLIV_35465  putative siderophore transport system ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
SLIV_02315  binding-protein-dependent transport lipoprotein [KO:K23227]
SLIV_02320  iron-hydroxamate transporter permease subunit [KO:K23228]
SLIV_02310  ABC transporter ATP-binding protein [KO:K10829] [EC:7.2.2.16]
SLIV_25160  ABC-transporter metal-binding lipoprotein [KO:K09815]
SLIV_25150  metal transport ABC transporter [KO:K09816]
SLIV_25155  metal transport ABC transporter [KO:K09817] [EC:7.2.2.20]
SLIV_08815  hypothetical protein [KO:K02009]
SLIV_21900  ABC-type cobalt transport system [KO:K02007]
SLIV_08810  cbiM; Cobalt transport protein CbiM [KO:K02007]
SLIV_21895  integral membrane transport protein [KO:K02008]
SLIV_08820  cobalt transport integral membrane protein [KO:K02008]
SLIV_21890  Putative ABC transporter ATP-binding protein [KO:K02006]
SLIV_08825  Putative ABC transporter ATP-binding protein [KO:K02006]
SLIV_24520  biotin synthase [KO:K03523]
SLIV_26105  integral membrane protein [KO:K16785]
SLIV_04730  ABC transporter membrane protein [KO:K09692]
SLIV_22725  ABC transporter [KO:K09692]
SLIV_22720  ABC transporter ATP-binding protein [KO:K09693] [EC:7.5.2.4]
SLIV_04725  ABC transporter ATP-binding protein [KO:K09693] [EC:7.5.2.4]
SLIV_30935  ABC transporter [KO:K09813]
SLIV_30940  ABC transporter ATP-binding protein [KO:K09814] [EC:7.6.2.-]
SLIV_26430  ABC transporter [KO:K18233]
SLIV_26435  putative Daunorubicin/doxorubicin resistance ATP-binding protein [KO:K18232]
SLIV_22860  cell division protein [KO:K09811]
SLIV_22855  ftsE; Cell division ATP-binding protein FtsE [KO:K09812]
SLIV_00855  ABC transporter ATP-binding protein [KO:K14698] [EC:7.-.-.-]
SLIV_00850  ABC transporter ATP-binding protein [KO:K14699] [EC:7.-.-.-]
SLIV_25370  putative ABC transporter ATP-binding protein [KO:K18887]
SLIV_25365  putative ABC transporter ATP-binding protein [KO:K18888]
SLIV_18585  ABC transporter [KO:K16014]
SLIV_36315  tlrC; Tylosin resistance ATP-binding protein TlrC [KO:K18230]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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