KEGG   PATHWAY: smil04141
Entry
smil04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Salvia miltiorrhiza (redroot sage)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
smil04141  Protein processing in endoplasmic reticulum
smil04141

Other DBs
GO: 0030433 0034976
Organism
Salvia miltiorrhiza (redroot sage) [GN:smil]
Gene
131013000  uncharacterized protein LOC131013000 [KO:K10956]
130985262  uncharacterized protein LOC130985262 [KO:K10956]
130986888  uncharacterized protein LOC130986888 [KO:K10956]
131000671  protein transport protein Sec61 subunit beta [KO:K09481]
131020620  protein transport protein Sec61 subunit beta-like [KO:K09481]
131021997  protein transport protein Sec61 subunit beta-like [KO:K09481]
130997607  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
131014811  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
130987831  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
131020178  protein transport protein Sec61 subunit gamma-1 [KO:K07342]
131004697  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
130996558  dnaJ protein ERDJ2-like [KO:K09540]
130996585  dnaJ protein ERDJ2-like [KO:K09540]
131011018  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
131001984  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
131014238  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
130988737  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
131023921  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
131005383  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like isoform X1 [KO:K12670]
131026504  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
130987900  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
131021506  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1 [KO:K07151] [EC:2.4.99.18]
131012947  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
130985760  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 [KO:K19478]
130997540  uncharacterized protein LOC130997540 [KO:K26501]
131006645  LOW QUALITY PROTEIN: uncharacterized protein LOC131006645 [KO:K26502]
131020164  LOW QUALITY PROTEIN: uncharacterized protein LOC131020164 [KO:K26502]
130995601  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
131012712  heat shock 70 kDa protein 17-like [KO:K09486]
131012794  heat shock 70 kDa protein 17-like [KO:K09486]
131014690  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
131018674  luminal-binding protein 5-like [KO:K09490] [EC:3.6.4.10]
131018816  luminal-binding protein 5-like [KO:K09490] [EC:3.6.4.10]
130995408  dnaJ protein ERDJ3B-like [KO:K09517]
131015603  dnaJ protein ERDJ3B-like [KO:K09517]
131023615  dnaJ protein P58IPK homolog B-like [KO:K09523]
130997713  dnaJ protein P58IPK homolog [KO:K09523]
131020557  dnaJ protein P58IPK homolog isoform X1 [KO:K09523]
130995925  heat shock protein 90-5, chloroplastic [KO:K09487]
131012715  LOW QUALITY PROTEIN: heat shock protein 90-6, mitochondrial [KO:K09487]
130986651  endoplasmin homolog isoform X1 [KO:K09487]
130989171  LOW QUALITY PROTEIN: probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
130999595  LOW QUALITY PROTEIN: glucosidase 2 subunit beta [KO:K08288]
130988000  calnexin homolog 1-like [KO:K08054]
131008957  calreticulin-like [KO:K08057]
130999869  calreticulin-3 [KO:K08057]
130989777  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
131007764  SEC12-like protein 2 isoform X1 [KO:K14003]
131014772  SEC12-like protein 1 [KO:K14003]
130986281  SEC12-like protein 2 isoform X1 [KO:K14003]
131017159  SEC12-like protein 2 isoform X1 [KO:K14003]
131017416  SEC12-like protein 2 isoform X1 [KO:K14003]
131009038  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
130995413  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
130997491  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
131000347  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
131003131  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
130992488  protein transport protein SEC13 homolog B-like [KO:K14004]
130989520  protein transport protein SEC13 homolog B-like [KO:K14004]
131006884  protein transport protein SEC31 homolog B-like [KO:K14005]
131006885  protein transport protein SEC31 homolog B-like [KO:K14005]
130992556  protein transport protein SEC23 E-like [KO:K14006]
131015885  protein transport protein SEC23 C-like [KO:K14006]
130991301  protein transport protein SEC23 G [KO:K14006]
130999451  protein transport protein SEC24 A-like [KO:K14007]
131016307  protein transport protein SEC24 A-like [KO:K14007]
130987902  protein transport protein SEC24 C-like isoform X1 [KO:K14007]
131020212  protein transport protein SEC24 B-like [KO:K14007]
131008817  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
131021215  alpha-mannosidase I MNS5 isoform X1 [KO:K10084]
130991306  alpha-mannosidase I MNS4 [KO:K10085]
130992446  protein disulfide isomerase-like 1-6 isoform X1 [KO:K09580] [EC:5.3.4.1]
131010164  protein disulfide isomerase-like 5-2 [KO:K09580] [EC:5.3.4.1]
131011872  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
131014901  protein disulfide isomerase-like 1-3 [KO:K09580] [EC:5.3.4.1]
131000648  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
130990010  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
131006572  protein disulfide isomerase-like 5-2 [KO:K09580] [EC:5.3.4.1]
131008981  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
131012699  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
130997488  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
131002334  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
131012115  endoplasmic reticulum oxidoreductin-1-like [KO:K10950] [EC:1.8.4.-]
131012154  endoplasmic reticulum oxidoreductin-1-like [KO:K10950] [EC:1.8.4.-]
131022793  endoplasmic reticulum oxidoreductin-1-like isoform X1 [KO:K10950] [EC:1.8.4.-]
131023035  endoplasmic reticulum oxidoreductin-1-like isoform X1 [KO:K10950] [EC:1.8.4.-]
130988160  protein OS-9 homolog isoform X1 [KO:K10088]
131001008  translocon-associated protein subunit alpha-like [KO:K13249]
131005515  translocon-associated protein subunit alpha [KO:K13249]
131016018  uncharacterized protein LOC131016018 [KO:K13250]
130987895  uncharacterized protein LOC130987895 [KO:K13250]
131023484  uncharacterized protein LOC131023484 [KO:K14009]
130999515  uncharacterized protein LOC130999515 [KO:K14009]
130999545  uncharacterized protein LOC130999545 [KO:K14009]
130985814  uncharacterized protein LOC130985814 [KO:K14009]
130985766  derlin-2.2 [KO:K13989]
130985973  derlin-1 isoform X1 [KO:K13989]
130997617  plant UBX domain-containing protein 11 isoform X1 [KO:K24348]
131001310  vicilin-like seed storage protein At2g18540 [KO:K24348]
130996050  plant UBX domain-containing protein 2 [KO:K14011]
130985836  plant UBX domain-containing protein 4 [KO:K14012]
131002355  plant UBX domain-containing protein 4-like [KO:K14012]
131002377  plant UBX domain-containing protein 4-like [KO:K14012]
130997773  cell division control protein 48 homolog E [KO:K13525]
131000085  cell division cycle protein 48 homolog [KO:K13525]
131000533  cell division cycle protein 48 homolog isoform X1 [KO:K13525]
131020526  cell division control protein 48 homolog E [KO:K13525]
130997177  NPL4-like protein 2 [KO:K14015]
131002905  NPL4-like protein 2 [KO:K14015]
130994526  uncharacterized protein LOC130994526 [KO:K14016]
131005527  uncharacterized protein LOC131005527 [KO:K14016]
131008923  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
131010170  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
130997578  heat shock cognate 70 kDa protein 2-like [KO:K03283]
131013960  heat shock cognate 70 kDa protein-like [KO:K03283]
131014001  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
131016687  heat shock cognate 70 kDa protein 2 [KO:K03283]
130991792  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130991793  heat shock cognate 70 kDa protein-like [KO:K03283]
130991794  heat shock cognate 70 kDa protein-like [KO:K03283]
130992121  heat shock cognate 70 kDa protein-like [KO:K03283]
131005880  heat shock cognate 70 kDa protein 2-like [KO:K03283]
131022212  heat shock cognate 70 kDa protein-like isoform X1 [KO:K03283]
131022213  heat shock cognate 70 kDa protein-like [KO:K03283]
131022214  heat shock cognate 70 kDa protein-like [KO:K03283]
131000256  dnaJ protein homolog [KO:K09503]
131006113  dnaJ protein homolog [KO:K09503]
131022473  dnaJ protein homolog [KO:K09503]
131008755  chaperone protein dnaJ 49-like [KO:K09518]
130986731  chaperone protein dnaJ 49-like [KO:K09518]
131004715  uncharacterized protein LOC131004715 [KO:K09518]
131004869  chaperone protein dnaJ 49-like [KO:K09518]
130991867  chaperone protein dnaJ 49 [KO:K09518]
130993423  heat shock protein 83 [KO:K04079]
131022831  heat shock cognate protein 80 [KO:K04079]
130993173  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
130993187  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131014707  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131014708  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131014709  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131014710  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131014711  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131014712  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131014734  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131003260  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131003261  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131003262  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
131023668  21.9 kDa heat shock protein-like [KO:K13993]
131025375  small heat shock protein, chloroplastic-like [KO:K13993]
130994512  16.9 kDa class I heat shock protein 1-like [KO:K13993]
130994741  16.9 kDa class I heat shock protein 1-like [KO:K13993]
130995467  heat shock 22 kDa protein, mitochondrial-like [KO:K13993]
130985776  15.4 kDa class V heat shock protein [KO:K13993]
130985987  18.1 kDa class I heat shock protein-like [KO:K13993]
131015460  17.3 kDa class II heat shock protein-like [KO:K13993]
131015464  17.3 kDa class II heat shock protein-like [KO:K13993]
131016612  17.5 kDa class I heat shock protein-like [KO:K13993]
131019746  small heat shock protein, chloroplastic-like [KO:K13993]
131002964  21.9 kDa heat shock protein-like [KO:K13993]
131003656  small heat shock protein, chloroplastic-like [KO:K13993]
131004238  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
130990537  17.4 kDa class III heat shock protein [KO:K13993]
131021938  LOW QUALITY PROTEIN: 15.7 kDa heat shock protein, peroxisomal [KO:K13993]
131005755  18.2 kDa class I heat shock protein-like [KO:K13993]
131005967  17.9 kDa class II heat shock protein-like [KO:K13993]
131005986  17.6 kDa class I heat shock protein-like isoform X1 [KO:K13993]
131005994  17.8 kDa class I heat shock protein-like [KO:K13993]
131006009  17.8 kDa class I heat shock protein-like [KO:K13993]
131006015  17.3 kDa class I heat shock protein-like [KO:K13993]
131006016  18.2 kDa class I heat shock protein-like [KO:K13993]
131006017  18.2 kDa class I heat shock protein-like [KO:K13993]
131006018  17.3 kDa class I heat shock protein-like [KO:K13993]
131006019  17.3 kDa class I heat shock protein-like [KO:K13993]
131006023  class I heat shock protein-like [KO:K13993]
131006024  class I heat shock protein-like [KO:K13993]
131006025  18.1 kDa class I heat shock protein-like [KO:K13993]
131006032  class I heat shock protein-like [KO:K13993]
131021734  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2-like [KO:K13719] [EC:3.1.2.-]
131021770  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2-like [KO:K13719] [EC:3.1.2.-]
131005346  uncharacterized protein LOC131005346 [KO:K14018]
131023937  ubiquitin receptor RAD23c-like [KO:K10839]
131023938  ubiquitin receptor RAD23c-like [KO:K10839]
131001617  ubiquitin receptor RAD23d-like [KO:K10839]
130988022  ubiquitin receptor RAD23b isoform X1 [KO:K10839]
131004480  ubiquitin receptor RAD23c-like [KO:K10839]
131004481  ubiquitin receptor RAD23c-like [KO:K10839]
131012437  ubiquitin domain-containing protein DSK2a-like [KO:K04523]
130989198  ubiquitin domain-containing protein DSK2b-like [KO:K04523]
131014368  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
131016595  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
130989616  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
131001999  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
131020039  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
131014087  LOW QUALITY PROTEIN: subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
131003031  subtilisin-like protease SBT6.1 isoform X1 [KO:K08653] [EC:3.4.21.112]
130987789  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
131023786  serine/threonine-protein kinase/endoribonuclease IRE1a-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
131011000  serine/threonine-protein kinase/endoribonuclease IRE1b-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
131021028  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
130992288  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
130990295  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
131006002  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
131025165  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
130995862  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
131013281  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
130988779  uncharacterized protein LOC130988779 [KO:K10666] [EC:2.3.2.27]
131013300  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
131012872  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
130985516  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
130986556  uncharacterized protein LOC130986556 [KO:K10666] [EC:2.3.2.27]
131008573  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
130995487  E3 ubiquitin protein ligase RIN2 isoform X1 [KO:K10636] [EC:2.3.2.36]
130999480  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
130993408  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
130998924  ubiquitin-conjugating enzyme E2 28-like isoform X1 [KO:K06689] [EC:2.3.2.23]
131014608  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
131019825  ubiquitin-conjugating enzyme E2 28-like isoform X1 [KO:K06689] [EC:2.3.2.23]
131002811  ubiquitin-conjugating enzyme E2 11-like [KO:K06689] [EC:2.3.2.23]
131020777  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
131020778  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
130992187  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
131006614  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
131001692  ubiquitin-conjugating enzyme E2 10-like isoform X1 [KO:K06689] [EC:2.3.2.23]
130987662  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
131021449  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
131021462  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
131020978  cullin-1-like [KO:K03347]
130991690  cullin-1 [KO:K03347]
131009041  SKP1-like protein 11 [KO:K03094]
131009044  SKP1-like protein 1 [KO:K03094]
130994372  SKP1-like protein 1A [KO:K03094]
131011123  SKP1-like protein 1A [KO:K03094]
131011459  SKP1-like protein 12 [KO:K03094]
131014821  SKP1-like protein 11 [KO:K03094]
131020735  SKP1-like protein 12 [KO:K03094]
130989297  SKP1-like protein 1A [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
smil00510  N-Glycan biosynthesis
smil03050  Proteasome
smil03060  Protein export
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system