Entry
Name
Protein processing in endoplasmic reticulum - Salvia miltiorrhiza (redroot sage)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
smil04141 Protein processing in endoplasmic reticulum
Ortholog table
Other DBs
Organism
Salvia miltiorrhiza (redroot sage) [GN:
smil ]
Gene
131011018 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666 ]
131001984 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666 ]
131014238 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667 ]
130988737 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668 ]
131023921 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670 ]
131005383 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like isoform X1 [KO:K12670 ]
131021506 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1 [KO:K07151 ] [EC:2.4.99.18 ]
131012947 probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478 ]
130985760 probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 [KO:K19478 ]
131006645 LOW QUALITY PROTEIN: uncharacterized protein LOC131006645 [KO:K26502 ]
131020164 LOW QUALITY PROTEIN: uncharacterized protein LOC131020164 [KO:K26502 ]
131012715 LOW QUALITY PROTEIN: heat shock protein 90-6, mitochondrial [KO:K09487 ]
131008817 UDP-glucose:glycoprotein glucosyltransferase [KO:K11718 ] [EC:2.4.1.-]
131012115 endoplasmic reticulum oxidoreductin-1-like [KO:K10950 ] [EC:1.8.4.-]
131012154 endoplasmic reticulum oxidoreductin-1-like [KO:K10950 ] [EC:1.8.4.-]
131022793 endoplasmic reticulum oxidoreductin-1-like isoform X1 [KO:K10950 ] [EC:1.8.4.-]
131023035 endoplasmic reticulum oxidoreductin-1-like isoform X1 [KO:K10950 ] [EC:1.8.4.-]
131008923 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
131010170 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
131014001 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
131021938 LOW QUALITY PROTEIN: 15.7 kDa heat shock protein, peroxisomal [KO:K13993 ]
131021734 OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2-like [KO:K13719 ] [EC:3.1.2.-]
131021770 OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2-like [KO:K13719 ] [EC:3.1.2.-]
131001999 eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237 ]
131020039 eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237 ]
131023786 serine/threonine-protein kinase/endoribonuclease IRE1a-like isoform X1 [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
131008573 ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026 ]
Compound
Reference
Authors
Naidoo N
Title
ER and aging-Protein folding and the ER stress response.
Journal
Reference
Authors
Malhotra JD, Kaufman RJ
Title
The endoplasmic reticulum and the unfolded protein response.
Journal
Reference
Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
Title
Protein quality control in the ER: the recognition of misfolded proteins.
Journal
Reference
Authors
Stolz A, Wolf DH
Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
Journal
Reference
Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
Journal
Related pathway
KO pathway
LinkDB
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