KEGG   PATHWAY: smq02030
Entry
smq02030                    Pathway                                
Name
Bacterial chemotaxis - Sinorhizobium meliloti BL225C
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
smq02030  Bacterial chemotaxis
smq02030

Other DBs
GO: 0006935
Organism
Sinorhizobium meliloti BL225C [GN:smq]
Gene
SinmeB_0049  methyl-accepting chemotaxis sensory transducer with Cache sensor [KO:K03406]
SinmeB_0080  methyl-accepting chemotaxis sensory transducer [KO:K03406]
SinmeB_0489  methyl-accepting chemotaxis sensory transducer with Cache sensor [KO:K03406]
SinmeB_0242  methyl-accepting chemotaxis sensory transducer [KO:K03406]
SinmeB_0316  methyl-accepting chemotaxis sensory transducer [KO:K03406]
SinmeB_6361  methyl-accepting chemotaxis sensory transducer [KO:K03406]
SinmeB_1648  methyl-accepting chemotaxis sensory transducer with Cache sensor [KO:K03406]
SinmeB_1974  methyl-accepting chemotaxis sensory transducer [KO:K03406]
SinmeB_2832  methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor [KO:K03406]
SinmeB_4648  putative sugar ABC transporter periplasmic sugar-binding protein ABC transporter [KO:K10439]
SinmeB_4180  putative ABC transporter periplasmic sugar-binding protein [KO:K10439]
SinmeB_4800  putative sugar uptake ABC transporter periplasmic solute-binding protein precursor [KO:K10439]
SinmeB_5550  putative ABC transporter, periplasmic solute-binding protein [KO:K10439]
SinmeB_4849  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_2396  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_3715  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_5420  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_3126  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_3524  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_5512  putative ABC transporter component [KO:K10439]
SinmeB_6292  hypothetical protein [KO:K10439]
SinmeB_3614  putative sugar uptake ABC transporter periplasmic solute-binding protein precursor [KO:K10439]
SinmeB_2966  periplasmic sugar-binding protein of sugar ABC transporter [KO:K10439]
SinmeB_2374  putative periplasmic binding protein [KO:K10439]
SinmeB_2362  putative periplasmic binding ABC transporter protein [KO:K10439]
SinmeB_5178  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_4975  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
SinmeB_0339  ABC-type transporter, periplasmic subunit [KO:K12368]
SinmeB_0245  CheA signal transduction histidine kinase [KO:K03407] [EC:2.7.13.3]
SinmeB_6362  CheA signal transduction histidine kinase [KO:K03407] [EC:2.7.13.3]
SinmeB_6360  CheW protein [KO:K03408]
SinmeB_1973  CheW protein [KO:K03408]
SinmeB_2831  CheW protein [KO:K03408]
SinmeB_0246  CheW protein [KO:K03408]
SinmeB_2550  response regulator receiver [KO:K03413]
SinmeB_0244  response regulator receiver protein [KO:K03413]
SinmeB_0249  response regulator receiver protein [KO:K03413]
SinmeB_0243  putative chemotaxis protein CheX [KO:K03409]
SinmeB_6363  response regulator receiver modulated CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
SinmeB_4170  CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
SinmeB_0248  response regulator receiver modulated CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
SinmeB_4169  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor [KO:K13924] [EC:2.1.1.80 3.1.1.61]
SinmeB_0250  CheD [KO:K03411] [EC:3.5.1.44]
SinmeB_0247  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
SinmeB_6359  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
SinmeB_0258  Flagellar motor switch protein FliG, C-terminal protein [KO:K02410]
SinmeB_0260  surface presentation of antigens (SPOA) protein [KO:K02416]
SinmeB_0259  flagellar motor switch protein FliN [KO:K02417]
SinmeB_0261  flagellar motor stator protein MotA [KO:K02556]
SinmeB_2607  OmpA/MotB domain protein [KO:K02557]
SinmeB_0281  OmpA/MotB domain protein [KO:K02557]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
smq02040  Flagellar assembly
KO pathway
ko02030   
LinkDB

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